Articles producció científica> Medicina i Cirurgia

Utility of ctDNA Liquid Biopsies from Cancer Patients: An Institutional Study of 285 ctDNA Samples

  • Datos identificativos

    Identificador: imarina:9287418
    Autores:
    Gumà JPeña KRiu FGuilarte CHernandez ALucía CMartínez-Madueño FMiranda MJCabezas IGrifoll MPeralta SSerrano SMuñoz FDelamo LRoig BBorràs JBadia JRodriguez-Balada MParada D
    Resumen:
    Liquid biopsy has improved significantly over the last decade and is attracting attention as a tool that can complement tissue biopsy to evaluate the genetic landscape of solid tumors. In the present study, we evaluated the usefulness of liquid biopsy in daily oncology practice in different clinical contexts. We studied ctDNA and tissue biopsy to investigate EGFR, KRAS, NRAS, and BRAF mutations from 199 cancer patients between January 2016 and March 2021. The study included 114 male and 85 female patients with a median age of 68 years. A total of 122 cases were lung carcinoma, 53 were colorectal carcinoma, and 24 were melanoma. Liquid biopsy was positive for a potentially druggable driver mutation in 14 lung and colorectal carcinoma where tissue biopsy was not performed, and in two (3%) lung carcinoma patients whose tissue biopsy was negative. Liquid biopsy identified nine (45%) de novo EGFR-T790M mutations during TKI-treatment follow-up in lung carcinoma. BRAF-V600 mutation resurgence was detected in three (12.5%) melanoma patients during follow-up. Our results confirm the value of liquid biopsy in routine clinical oncologic practice for targeted therapy, diagnosis of resistance to treatment, and cancer follow-up.
  • Otros:

    Autor según el artículo: Gumà J; Peña K; Riu F; Guilarte C; Hernandez A; Lucía C; Martínez-Madueño F; Miranda MJ; Cabezas I; Grifoll M; Peralta S; Serrano S; Muñoz F; Delamo L; Roig B; Borràs J; Badia J; Rodriguez-Balada M; Parada D
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: BORRAS BALADA, JOAN LLUÍS / Gumà Padró, José / Lucia Gozalvez, Clara Beatriz / RODRÍGUEZ BALADA, MARTA
    Palabras clave: Precision medicine Melanoma Lung Liquid biopsy Ctdna Colorectal Cell lung-cancer Cancer survival ras mutations precision medicine osimertinib melanoma lung ctdna colorectal cancer
    Resumen: Liquid biopsy has improved significantly over the last decade and is attracting attention as a tool that can complement tissue biopsy to evaluate the genetic landscape of solid tumors. In the present study, we evaluated the usefulness of liquid biopsy in daily oncology practice in different clinical contexts. We studied ctDNA and tissue biopsy to investigate EGFR, KRAS, NRAS, and BRAF mutations from 199 cancer patients between January 2016 and March 2021. The study included 114 male and 85 female patients with a median age of 68 years. A total of 122 cases were lung carcinoma, 53 were colorectal carcinoma, and 24 were melanoma. Liquid biopsy was positive for a potentially druggable driver mutation in 14 lung and colorectal carcinoma where tissue biopsy was not performed, and in two (3%) lung carcinoma patients whose tissue biopsy was negative. Liquid biopsy identified nine (45%) de novo EGFR-T790M mutations during TKI-treatment follow-up in lung carcinoma. BRAF-V600 mutation resurgence was detected in three (12.5%) melanoma patients during follow-up. Our results confirm the value of liquid biopsy in routine clinical oncologic practice for targeted therapy, diagnosis of resistance to treatment, and cancer follow-up.
    Áreas temáticas: Oncology Medicina iii Cancer research
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: clara.lucia@estudiants.urv.cat jose.guma@urv.cat
    Identificador del autor: 0000-0001-6965-4529 0000-0001-7541-9832
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2072-6694/14/23/5859
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Cancers. 14 (23):
    Referencia de l'ítem segons les normes APA: Gumà J; Peña K; Riu F; Guilarte C; Hernandez A; Lucía C; Martínez-Madueño F; Miranda MJ; Cabezas I; Grifoll M; Peralta S; Serrano S; Muñoz F; Delamo L (2022). Utility of ctDNA Liquid Biopsies from Cancer Patients: An Institutional Study of 285 ctDNA Samples. Cancers, 14(23), -. DOI: 10.3390/cancers14235859
    DOI del artículo: 10.3390/cancers14235859
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Cancer Research,Oncology
    Precision medicine
    Melanoma
    Lung
    Liquid biopsy
    Ctdna
    Colorectal
    Cell lung-cancer
    Cancer
    survival
    ras mutations
    precision medicine
    osimertinib
    melanoma
    lung
    ctdna
    colorectal
    cancer
    Oncology
    Medicina iii
    Cancer research
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