Articles producció científica> Medicina i Cirurgia

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

  • Identification data

    Identifier: imarina:9294516
    Handle: http://hdl.handle.net/20.500.11797/imarina9294516
  • Authors:

    Vogelezang, S
    Bradfield, JP
    Grant, SFA
    Felix, JF
    Jaddoe, VWV
  • Others:

    Author, as appears in the article.: Vogelezang, S; Bradfield, JP; Grant, SFA; Felix, JF; Jaddoe, VWV
    Department: Medicina i Cirurgia
    URV's Author/s: Escribano Subías, Joaquín
    Keywords: Association Birth Brain size Childhood Common variants Expression Genetic correlations Genome-wide association study Growth Head circumference Heritability Infancy Ld score regression Mendelian randomization
    Abstract: Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
    Thematic Areas: Biotecnología Ciência da computação Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Farmacia Genetics Genetics & heredity Genetics (clinical) Interdisciplinar Medicina i Medicina ii Medicina iii Odontología Psicología Saúde coletiva
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joaquin.escribano@urv.cat
    Author identifier: 0000-0002-5041-459X
    Record's date: 2023-05-14
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-022-01281-1
    Papper original source: Bmc Medical Genomics. 15 (1): 124-
    APA: Vogelezang, S; Bradfield, JP; Grant, SFA; Felix, JF; Jaddoe, VWV (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. Bmc Medical Genomics, 15(1), 124-. DOI: 10.1186/s12920-022-01281-1
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1186/s12920-022-01281-1
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Genetics,Genetics & Heredity,Genetics (Clinical)
    Association
    Birth
    Brain size
    Childhood
    Common variants
    Expression
    Genetic correlations
    Genome-wide association study
    Growth
    Head circumference
    Heritability
    Infancy
    Ld score regression
    Mendelian randomization
    Biotecnología
    Ciência da computação
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Farmacia
    Genetics
    Genetics & heredity
    Genetics (clinical)
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Odontología
    Psicología
    Saúde coletiva
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