Author, as appears in the article.: Vogelezang, Suzanne; Bradfield, Jonathan P.; Grant, Struan F. A.; Felix, Janine F.; Jaddoe, Vincent W. V.;Early Growth Genetics Consortium
Department: Medicina i Cirurgia
URV's Author/s: Escribano Subías, Joaquín
Keywords: Mendelian randomization Ld score regression Infancy Heritability Head circumference Growth Genome-wide association study Genetic correlations Expression Common variants Childhood Brain size Birth Association
Abstract: Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
Thematic Areas: Saúde coletiva Psicología Odontología Medicina iii Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: joaquin.escribano@urv.cat
Author identifier: 0000-0002-5041-459X
Record's date: 2024-09-07
Paper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Bmc Medical Genomics. 15 (1): 124-
APA: Vogelezang, Suzanne; Bradfield, Jonathan P.; Grant, Struan F. A.; Felix, Janine F.; Jaddoe, Vincent W. V.;Early Growth Genetics Consortium (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. Bmc Medical Genomics, 15(1), 124-. DOI: 10.1186/s12920-022-01281-1
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV