Author, as appears in the article.: Vogelezang, S; Bradfield, JP; Grant, SFA; Felix, JF; Jaddoe, VWV

Department: Medicina i Cirurgia

URV's Author/s: Escribano Subías, Joaquín

Keywords: Association Birth Brain size Childhood Common variants Expression Genetic correlations Genome-wide association study Growth Head circumference Heritability Infancy Ld score regression Mendelian randomization

Abstract: Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

Thematic Areas: Biotecnología Ciência da computação Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Farmacia Genetics Genetics & heredity Genetics (clinical) Interdisciplinar Medicina i Medicina ii Medicina iii Odontología Psicología Saúde coletiva

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: joaquin.escribano@urv.cat

Author identifier: 0000-0002-5041-459X

Record's date: 2023-05-14

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-022-01281-1

Papper original source: Bmc Medical Genomics. 15 (1): 124-

APA: Vogelezang, S; Bradfield, JP; Grant, SFA; Felix, JF; Jaddoe, VWV (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. Bmc Medical Genomics, 15(1), 124-. DOI: 10.1186/s12920-022-01281-1

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Article's DOI: 10.1186/s12920-022-01281-1

Entity: Universitat Rovira i Virgili

Journal publication year: 2022

Publication Type: Journal Publications