Articles producció científica> Medicina i Cirurgia

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

  • Datos identificativos

    Identificador: imarina:9294516
    Autores:
    Vogelezang, SuzanneBradfield, Jonathan P.Grant, Struan F. A.Felix, Janine F.Jaddoe, Vincent W. V.Early Growth Genetics Consortium
    Resumen:
    Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
  • Otros:

    Autor según el artículo: Vogelezang, Suzanne; Bradfield, Jonathan P.; Grant, Struan F. A.; Felix, Janine F.; Jaddoe, Vincent W. V.;Early Growth Genetics Consortium
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Escribano Subías, Joaquín
    Palabras clave: Mendelian randomization Ld score regression Infancy Heritability Head circumference Growth Genome-wide association study Genetic correlations Expression Common variants Childhood Brain size Birth Association
    Resumen: Background Head circumference is associated with intelligence and tracks from childhood into adulthood. Methods We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age. Results Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes. Conclusions The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.
    Áreas temáticas: Saúde coletiva Psicología Odontología Medicina iii Medicina ii Medicina i Interdisciplinar Genetics (clinical) Genetics & heredity Genetics Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência da computação Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: joaquin.escribano@urv.cat
    Identificador del autor: 0000-0002-5041-459X
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://bmcmedgenomics.biomedcentral.com/articles/10.1186/s12920-022-01281-1
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Bmc Medical Genomics. 15 (1): 124-
    Referencia de l'ítem segons les normes APA: Vogelezang, Suzanne; Bradfield, Jonathan P.; Grant, Struan F. A.; Felix, Janine F.; Jaddoe, Vincent W. V.;Early Growth Genetics Consortium (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. Bmc Medical Genomics, 15(1), 124-. DOI: 10.1186/s12920-022-01281-1
    DOI del artículo: 10.1186/s12920-022-01281-1
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2022
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Genetics,Genetics & Heredity,Genetics (Clinical)
    Mendelian randomization
    Ld score regression
    Infancy
    Heritability
    Head circumference
    Growth
    Genome-wide association study
    Genetic correlations
    Expression
    Common variants
    Childhood
    Brain size
    Birth
    Association
    Saúde coletiva
    Psicología
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Genetics (clinical)
    Genetics & heredity
    Genetics
    Farmacia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência da computação
    Biotecnología
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