Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS)

  • Identification data

    Identifier: imarina:9296451
  • Authors:

    Escobar-Morreale, HF
    Martínez-García, MA
    Insenser, M
    Cañellas, N
    Correig, X
    Luque-Ramírez, M
  • Others:

    Author, as appears in the article.: Escobar-Morreale, HF; Martínez-García, MA; Insenser, M; Cañellas, N; Correig, X; Luque-Ramírez, M
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Cañellas Alberich, Nicolau / Correig Blanchar, Francesc Xavier
    Keywords: Subcutaneous adipose-tissue Sex Polycystic ovary syndrome Obesity Metabolism Estrogens Androgens sex prevalence polycystic ovary syndrome obesity obese women muscle mass metabolism mechanisms insulin-resistance glucose expression etiology estrogens androgen excess
    Abstract: Background: The polycystic ovary syndrome (PCOS) is associated with insulin resistance, obesity and cardiometabolic comorbidities. We here challenged the hypothesis, using state-of-the art proton nuclear magnetic resonance spectroscopy metabolomics profiling, that androgen excess in women induces also a certain masculinization of intermediate metabolism that is modulated by obesity. Methods: Participants were 53 Caucasian young adults, including 17 women with classic PCOS consisting of hyperandrogenism and ovulatory dysfunction, 17 non-hyperandrogenic women presenting with regular menses, and 19 healthy men, selected in order to be similar in terms of age and body mass index (BMI). Half of the subjects had obesity defined by a body mass index ≥ 30 kg/m2. Subjects maintained the same diet unrestricted in carbohydrates for 3 days before sampling and maintained their lifestyle and exercise patterns prior and during the study. Plasma samples were submitted to proton nuclear magnetic resonance spectroscopy metabolomics profiling. Results: Obesity associated a metabolomics profile mainly characterized by increased branched chain and aromatic aminoacids. Regardless of obesity, this unfavorable profile also characterized men as compared with control women, and was shared by women with PCOS. Notably, the negative impact of obesity on metabolomics profile was restricted to women, with obese men showing no further deterioration when compared with their non-obese counterparts. Conclusions: Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism, and masculinization of intermediate metabolism in women with PCOS, further suggesting a role for sex and sex hormones in the regulation of intermediate metabolism.
    Thematic Areas: Genetics & heredity Gender studies Endocrinology & metabolism Endocrinology Ciencias sociales Ciências biológicas ii
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: xavier.correig@urv.cat nicolau.canyellas@urv.cat
    Author identifier: 0000-0002-6902-3054 0000-0003-4856-8132
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bsd.biomedcentral.com/articles/10.1186/s13293-023-00507-w
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biology Of Sex Differences. 14 (1): 21-
    APA: Escobar-Morreale, HF; Martínez-García, MA; Insenser, M; Cañellas, N; Correig, X; Luque-Ramírez, M (2023). Serum metabolomics profiling by proton nuclear magnetic resonance spectroscopy reveals sexual dimorphism and masculinization of intermediate metabolism in women with polycystic ovary syndrome (PCOS). Biology Of Sex Differences, 14(1), 21-. DOI: 10.1186/s13293-023-00507-w
    Article's DOI: 10.1186/s13293-023-00507-w
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Endocrinology,Endocrinology & Metabolism,Gender Studies,Genetics & Heredity
    Subcutaneous adipose-tissue
    Sex
    Polycystic ovary syndrome
    Obesity
    Metabolism
    Estrogens
    Androgens
    sex
    prevalence
    polycystic ovary syndrome
    obesity
    obese women
    muscle mass
    metabolism
    mechanisms
    insulin-resistance
    glucose
    expression
    etiology
    estrogens
    androgen excess
    Genetics & heredity
    Gender studies
    Endocrinology & metabolism
    Endocrinology
    Ciencias sociales
    Ciências biológicas ii
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