Articles producció científica> Medicina i Cirurgia

[Use of isoflurane as treatment for super-refractory status epilepticus]

  • Identification data

    Identifier: imarina:9296511
    Authors:
    Plans-Galván ODaniel XRosich SBlázquez-Alcaide VGil-Castillejos DBodí M
    Abstract:
    Super-refractory status epilepticus (SRSE) is a neurological condition with an important morbidity and mortality rate, for which few therapeutic options are available. Inhalation sedation with isoflurane is currently a compassionate-use treatment in Spanish intensive care units. Little has been written about its usefulness in the treatment of refractory and super-refractory status epilepticus, but it appears to be a useful and safe therapeutic alternative for this condition.This article reviews three cases of SRSE treated with isoflurane. The capacity of isoflurane to control seizures was assessed by electroencephalographic monitoring. Other variables assessed were time to seizure control, survival, functional outcome and occurrence of complications secondary to isoflurane. In the three cases reviewed, isoflurane proved to be effective for seizure control in patients affected by SRSE. Seizure control was accomplished quickly and the minimum dose required to obtain a burst-suppression pattern was titrated easily and rapidly. Despite controlling epilepsy, high mortality was observed (66.66%). This is explained by both the mortality of SRSE and the underlying pathologies of the patients who died. The use of isoflurane did not give rise to any complications.With the results obtained, it is feasible to think that the use of isoflurane is not related to lesions in the central nervous system reported in other articles, and this treatment can be considered effective and safe for the control of SRSE.
  • Others:

    Author, as appears in the article.: Plans-Galván O; Daniel X; Rosich S; Blázquez-Alcaide V; Gil-Castillejos D; Bodí M
    Department: Medicina i Cirurgia
    URV's Author/s: Bodi Saera, Maria Amparo
    Keywords: Epilepsy super-refractory status epilepticus status epilepticus sedation isoflurane epileptic seizures
    Abstract: Super-refractory status epilepticus (SRSE) is a neurological condition with an important morbidity and mortality rate, for which few therapeutic options are available. Inhalation sedation with isoflurane is currently a compassionate-use treatment in Spanish intensive care units. Little has been written about its usefulness in the treatment of refractory and super-refractory status epilepticus, but it appears to be a useful and safe therapeutic alternative for this condition.This article reviews three cases of SRSE treated with isoflurane. The capacity of isoflurane to control seizures was assessed by electroencephalographic monitoring. Other variables assessed were time to seizure control, survival, functional outcome and occurrence of complications secondary to isoflurane. In the three cases reviewed, isoflurane proved to be effective for seizure control in patients affected by SRSE. Seizure control was accomplished quickly and the minimum dose required to obtain a burst-suppression pattern was titrated easily and rapidly. Despite controlling epilepsy, high mortality was observed (66.66%). This is explained by both the mortality of SRSE and the underlying pathologies of the patients who died. The use of isoflurane did not give rise to any complications.With the results obtained, it is feasible to think that the use of isoflurane is not related to lesions in the central nervous system reported in other articles, and this treatment can be considered effective and safe for the control of SRSE.
    Thematic Areas: Saúde coletiva Psicología Neurology (clinical) Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Engenharias iii Educação física Clinical neurology Ciências biológicas ii Ciências biológicas i
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
    Author identifier: 0000-0001-7652-8379 0000-0001-7652-8379
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://neurologia.com/articulo/2022191
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Revista De Neurologia. 76 (9): 309-312
    APA: Plans-Galván O; Daniel X; Rosich S; Blázquez-Alcaide V; Gil-Castillejos D; Bodí M (2023). [Use of isoflurane as treatment for super-refractory status epilepticus]. Revista De Neurologia, 76(9), 309-312. DOI: 10.33588/rn.7609.2022191
    Article's DOI: 10.33588/rn.7609.2022191
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Clinical Neurology,Medicine (Miscellaneous),Neurology (Clinical)
    Epilepsy
    super-refractory status epilepticus
    status epilepticus
    sedation
    isoflurane
    epileptic seizures
    Saúde coletiva
    Psicología
    Neurology (clinical)
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Engenharias iii
    Educação física
    Clinical neurology
    Ciências biológicas ii
    Ciências biológicas i
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