Articles producció científica> Medicina i Cirurgia

[Use of isoflurane as treatment for super-refractory status epilepticus]

  • Datos identificativos

    Identificador: imarina:9296511
    Autores:
    Plans-Galván ODaniel XRosich SBlázquez-Alcaide VGil-Castillejos DBodí M
    Resumen:
    Super-refractory status epilepticus (SRSE) is a neurological condition with an important morbidity and mortality rate, for which few therapeutic options are available. Inhalation sedation with isoflurane is currently a compassionate-use treatment in Spanish intensive care units. Little has been written about its usefulness in the treatment of refractory and super-refractory status epilepticus, but it appears to be a useful and safe therapeutic alternative for this condition.This article reviews three cases of SRSE treated with isoflurane. The capacity of isoflurane to control seizures was assessed by electroencephalographic monitoring. Other variables assessed were time to seizure control, survival, functional outcome and occurrence of complications secondary to isoflurane. In the three cases reviewed, isoflurane proved to be effective for seizure control in patients affected by SRSE. Seizure control was accomplished quickly and the minimum dose required to obtain a burst-suppression pattern was titrated easily and rapidly. Despite controlling epilepsy, high mortality was observed (66.66%). This is explained by both the mortality of SRSE and the underlying pathologies of the patients who died. The use of isoflurane did not give rise to any complications.With the results obtained, it is feasible to think that the use of isoflurane is not related to lesions in the central nervous system reported in other articles, and this treatment can be considered effective and safe for the control of SRSE.
  • Otros:

    Autor según el artículo: Plans-Galván O; Daniel X; Rosich S; Blázquez-Alcaide V; Gil-Castillejos D; Bodí M
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Bodi Saera, Maria Amparo
    Palabras clave: Epilepsy super-refractory status epilepticus status epilepticus sedation isoflurane epileptic seizures
    Resumen: Super-refractory status epilepticus (SRSE) is a neurological condition with an important morbidity and mortality rate, for which few therapeutic options are available. Inhalation sedation with isoflurane is currently a compassionate-use treatment in Spanish intensive care units. Little has been written about its usefulness in the treatment of refractory and super-refractory status epilepticus, but it appears to be a useful and safe therapeutic alternative for this condition.This article reviews three cases of SRSE treated with isoflurane. The capacity of isoflurane to control seizures was assessed by electroencephalographic monitoring. Other variables assessed were time to seizure control, survival, functional outcome and occurrence of complications secondary to isoflurane. In the three cases reviewed, isoflurane proved to be effective for seizure control in patients affected by SRSE. Seizure control was accomplished quickly and the minimum dose required to obtain a burst-suppression pattern was titrated easily and rapidly. Despite controlling epilepsy, high mortality was observed (66.66%). This is explained by both the mortality of SRSE and the underlying pathologies of the patients who died. The use of isoflurane did not give rise to any complications.With the results obtained, it is feasible to think that the use of isoflurane is not related to lesions in the central nervous system reported in other articles, and this treatment can be considered effective and safe for the control of SRSE.
    Áreas temáticas: Saúde coletiva Psicología Neurology (clinical) Medicine (miscellaneous) Medicine (all) Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Engenharias iii Educação física Clinical neurology Ciências biológicas ii Ciências biológicas i
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: mariaamparo.bodi@urv.cat mariaamparo.bodi@urv.cat
    Identificador del autor: 0000-0001-7652-8379 0000-0001-7652-8379
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://neurologia.com/articulo/2022191
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Revista De Neurologia. 76 (9): 309-312
    Referencia de l'ítem segons les normes APA: Plans-Galván O; Daniel X; Rosich S; Blázquez-Alcaide V; Gil-Castillejos D; Bodí M (2023). [Use of isoflurane as treatment for super-refractory status epilepticus]. Revista De Neurologia, 76(9), 309-312. DOI: 10.33588/rn.7609.2022191
    DOI del artículo: 10.33588/rn.7609.2022191
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Clinical Neurology,Medicine (Miscellaneous),Neurology (Clinical)
    Epilepsy
    super-refractory status epilepticus
    status epilepticus
    sedation
    isoflurane
    epileptic seizures
    Saúde coletiva
    Psicología
    Neurology (clinical)
    Medicine (miscellaneous)
    Medicine (all)
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Engenharias iii
    Educação física
    Clinical neurology
    Ciências biológicas ii
    Ciências biológicas i
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