Articles producció científica> Bioquímica i Biotecnologia

Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues

  • Identification data

    Identifier: imarina:9296941
    Authors:
    Sierra-Cruz, MartaMiguens-Gomez, AlbaRodriguez-Gallego, EstherD'Addario, ClaudioDi Bartolomeo, MartinaBlay, M TeresaPinent, MontserratBeltran-Debon, RaillTerra, Ximena
    Abstract:
    Diet-associated alterations of the intestinal barrier and gut microbiota promote intestinal lipopolysaccharide (LPS) translocation from the lumen to the lamina propria through different pathways, leading to an increase in LPS levels in the plasma known as metabolic endotoxemia. As a pharmacological dose of grape seed proanthocyanidin extract (GSPE) can reduce metabolic endotoxemia of obese rats, in the current study, we aimed to evaluate GSPE modulation of LPS translocation and the underlying mechanisms. We performed both an in vitro experiment with Caco-2 cells and an in vivo experiment with Wistar female rats fed a cafeteria (CAF) diet. GSPE was effective in regulating intestinal permeability through the modulation of receptor-mediated endocytosis pathway, as well as the gut microbiota interaction with the endocannabinoid system through epigenetic mechanisms. Our results confirm that GSPE can ameliorate intestinal dysfunction and metabolic endotoxemia caused by an excess of dietary lipids by modulating the endotoxin-translocation pathways.
  • Others:

    Author, as appears in the article.: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; D'Addario, Claudio; Di Bartolomeo, Martina; Blay, M Teresa; Pinent, Montserrat; Beltran-Debon, Raill; Terra, Ximena
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
    Keywords: Systemic inflammation Proanthocyanidins Metabolic endotoxemia Intestinal permeability Gut microbiota
    Abstract: Diet-associated alterations of the intestinal barrier and gut microbiota promote intestinal lipopolysaccharide (LPS) translocation from the lumen to the lamina propria through different pathways, leading to an increase in LPS levels in the plasma known as metabolic endotoxemia. As a pharmacological dose of grape seed proanthocyanidin extract (GSPE) can reduce metabolic endotoxemia of obese rats, in the current study, we aimed to evaluate GSPE modulation of LPS translocation and the underlying mechanisms. We performed both an in vitro experiment with Caco-2 cells and an in vivo experiment with Wistar female rats fed a cafeteria (CAF) diet. GSPE was effective in regulating intestinal permeability through the modulation of receptor-mediated endocytosis pathway, as well as the gut microbiota interaction with the endocannabinoid system through epigenetic mechanisms. Our results confirm that GSPE can ameliorate intestinal dysfunction and metabolic endotoxemia caused by an excess of dietary lipids by modulating the endotoxin-translocation pathways.
    Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
    Author identifier: 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
    Record's date: 2024-10-19
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S1756464623001664
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Functional Foods. 105 105566-
    APA: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; D'Addario, Claudio; Di Bartolomeo, Martina; Blay, M Teresa; Pinent, Montserrat; Be (2023). Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues. Journal Of Functional Foods, 105(), 105566-. DOI: 10.1016/j.jff.2023.105566
    Article's DOI: 10.1016/j.jff.2023.105566
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Systemic inflammation
    Proanthocyanidins
    Metabolic endotoxemia
    Intestinal permeability
    Gut microbiota
    Saúde coletiva
    Química
    Odontología
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias iii
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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