Author, as appears in the article.: Sierra-Cruz, M; Miguéns-Gómez, A; Rodríguez-Gallego, E; D'Addario, C; Di Bartolomeo, M; Blay, MT; Pinent, M; Beltrán-Debón, R; Terra, X
Department: Bioquímica i Biotecnologia
URV's Author/s: Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
Keywords: Systemic inflammation Proanthocyanidins Metabolic endotoxemia Intestinal permeability Gut microbiota
Abstract: Diet-associated alterations of the intestinal barrier and gut microbiota promote intestinal lipopolysaccharide (LPS) translocation from the lumen to the lamina propria through different pathways, leading to an increase in LPS levels in the plasma known as metabolic endotoxemia. As a pharmacological dose of grape seed proanthocyanidin extract (GSPE) can reduce metabolic endotoxemia of obese rats, in the current study, we aimed to evaluate GSPE modulation of LPS translocation and the underlying mechanisms. We performed both an in vitro experiment with Caco-2 cells and an in vivo experiment with Wistar female rats fed a cafeteria (CAF) diet. GSPE was effective in regulating intestinal permeability through the modulation of receptor-mediated endocytosis pathway, as well as the gut microbiota interaction with the endocannabinoid system through epigenetic mechanisms. Our results confirm that GSPE can ameliorate intestinal dysfunction and metabolic endotoxemia caused by an excess of dietary lipids by modulating the endotoxin-translocation pathways.
Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: raul.beltran@urv.cat montserrat.pinent@urv.cat esther.rodriguez@urv.cat mteresa.blay@urv.cat ximena.terra@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat alba.miguens@urv.cat alba.miguens@urv.cat
Author identifier: 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-1043-5844
Record's date: 2024-04-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S1756464623001664
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Functional Foods. 105
APA: Sierra-Cruz, M; Miguéns-Gómez, A; Rodríguez-Gallego, E; D'Addario, C; Di Bartolomeo, M; Blay, MT; Pinent, M; Beltrán-Debón, R; Terra, X (2023). Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues. Journal Of Functional Foods, 105(), -. DOI: 10.1016/j.jff.2023.105566
Article's DOI: 10.1016/j.jff.2023.105566
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV