Autor según el artículo: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; D'Addario, Claudio; Di Bartolomeo, Martina; Blay, M Teresa; Pinent, Montserrat; Beltran-Debon, Raill; Terra, Ximena
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Miguéns Gómez, Alba / Pinent Armengol, Montserrat / Rodríguez Gallego, Esther / Sierra Cruz, Marta / Terra Barbadora, Ximena
Palabras clave: Systemic inflammation Proanthocyanidins Metabolic endotoxemia Intestinal permeability Gut microbiota
Resumen: Diet-associated alterations of the intestinal barrier and gut microbiota promote intestinal lipopolysaccharide (LPS) translocation from the lumen to the lamina propria through different pathways, leading to an increase in LPS levels in the plasma known as metabolic endotoxemia. As a pharmacological dose of grape seed proanthocyanidin extract (GSPE) can reduce metabolic endotoxemia of obese rats, in the current study, we aimed to evaluate GSPE modulation of LPS translocation and the underlying mechanisms. We performed both an in vitro experiment with Caco-2 cells and an in vivo experiment with Wistar female rats fed a cafeteria (CAF) diet. GSPE was effective in regulating intestinal permeability through the modulation of receptor-mediated endocytosis pathway, as well as the gut microbiota interaction with the endocannabinoid system through epigenetic mechanisms. Our results confirm that GSPE can ameliorate intestinal dysfunction and metabolic endotoxemia caused by an excess of dietary lipids by modulating the endotoxin-translocation pathways.
Áreas temáticas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: alba.miguens@urv.cat alba.miguens@urv.cat alba.miguens@urv.cat marta.sierra@estudiants.urv.cat marta.sierra@estudiants.urv.cat ximena.terra@urv.cat mteresa.blay@urv.cat esther.rodriguez@urv.cat montserrat.pinent@urv.cat raul.beltran@urv.cat
Identificador del autor: 0000-0003-1043-5844 0000-0002-6256-9847 0000-0003-3550-5378 0000-0001-9691-1906
Fecha de alta del registro: 2024-10-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S1756464623001664
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Journal Of Functional Foods. 105 105566-
Referencia de l'ítem segons les normes APA: Sierra-Cruz, Marta; Miguens-Gomez, Alba; Rodriguez-Gallego, Esther; D'Addario, Claudio; Di Bartolomeo, Martina; Blay, M Teresa; Pinent, Montserrat; Be (2023). Effects of grape seed proanthocyanidin extract on lipopolysaccharide translocation and trafficking from the gut to tissues. Journal Of Functional Foods, 105(), 105566-. DOI: 10.1016/j.jff.2023.105566
DOI del artículo: 10.1016/j.jff.2023.105566
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV