Articles producció científica> Medicina i Cirurgia

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

  • Identification data

    Identifier: imarina:9297697
    Handle: http://hdl.handle.net/20.500.11797/imarina9297697
  • Authors:

    Kostaki, Evangelia-Georgia
    Flampouris, Andreas
    Karamitros, Timokratis
    Chueca, Natalia
    Alvarez, Marta
    Casas, Paz
    Alejos, Belen
    Hatzakis, Angelos
    Garcia, Federico
    Paraskevis, Dimitrios
    Moreno, Santiago
    Jarrin, Inma
    Dalmau, David
    Navarro, Maria Luisa
    Gonzalez, Maria Isabel
    Blanco, Jose Luis
    Rubio, Rafael
    Gutierrez, Felix
    Vidal, Francesc
    Berenguer, Juan
    Gonzalez, Juan
    Hernando, Victoria
    Moreno, Cristina
    Iniesta, Carlos
    Sousa, Luis Miguel Garcia
    Perez, Nieves Sanz
    Angeles Munoz-Fernandez, M.
    Maria Garcia-Merino, Isabel
    Consuegra Fernandez, Irene
    Gomez Rico, Coral
    Gallego de la Fuente, Jorge
    Palau Concejo, Paula
    Portilla, Joaquin
    Merino, Esperanza
    Reus, Sergio
    Boix, Vicente
    Giner, Livia
    Gadea, Carmen
    Portilla, Irene
    Pampliega, Maria
    Diez, Marcos
    Carlos Rodriguez, Juan
    Sanchez-Paya, Jose
    Luis Gomez, Juan
    Hernandez, Jehovana
    Remedios Aleman, Maria
    del Mar Alonso, Maria
    Inmaculada Hernandez, Maria
    Diaz-Flores, Felicitas
    Garcia, Dacil
    Pelazas, Ricardo
    Lopez Lirola, Ana
    Sanz Moreno, Jose
    Arranz Caso, Alberto
    Hernandez Gutierrez, Cristina
    Novella Mena, Maria
    Pulido, Federico
    Bisbal, Otilia
    Hernando, Asuncion
    Dominguez, Lourdes
    Rial Crestelo, David
    Bermejo, Laura
    Santacreu, Mireia
    Antonio Iribarrena, Jose
    Arrizabalaga, Julio
    Jose Aramburu, Maria
    Camino, Xabier
    Rodriguez-Arrondo, Francisco
    Angel von Wichmann, Miguel
    Pascual Tome, Lidia
    Angel Goenaga, Miguel
    Jesus Bustinduy, Ma
    Azkune, Harkaitz
    Ibarguren, Maialen
    Lizardi, Aitziber
    Kortajarena, Xabier
    Masia, Mar
    Padilla, Sergio
    Navarro, Andres
    Montolio, Fernando
    Robledano, Catalina
    Gregori Colome, Joan
    Adsuar, Araceli
    Pascual, Rafael
    Fernandez, Marta
    Garcia, Elena
    Alberto Garcia, Jose
    Barber, Xavier
    Bernaldo de Quiros, Juan Carlos Lopez
    Gutierrez,
  • Others:

    Author, as appears in the article.: Kostaki, Evangelia-Georgia; Flampouris, Andreas; Karamitros, Timokratis; Chueca, Natalia; Alvarez, Marta; Casas, Paz; Alejos, Belen; Hatzakis, Angelos; Garcia, Federico; Paraskevis, Dimitrios; Moreno, Santiago; Jarrin, Inma; Dalmau, David; Navarro, Maria Luisa; Gonzalez, Maria Isabel; Blanco, Jose Luis; Rubio, Rafael; Gutierrez, Felix; Vidal, Francesc; Berenguer, Juan; Gonzalez, Juan; Hernando, Victoria; Moreno, Cristina; Iniesta, Carlos; Sousa, Luis Miguel Garcia; Perez, Nieves Sanz; Angeles Munoz-Fernandez, M.; Maria Garcia-Merino, Isabel; Consuegra Fernandez, Irene; Gomez Rico, Coral; Gallego de la Fuente, Jorge; Palau Concejo, Paula; Portilla, Joaquin; Merino, Esperanza; Reus, Sergio; Boix, Vicente; Giner, Livia; Gadea, Carmen; Portilla, Irene; Pampliega, Maria; Diez, Marcos; Carlos Rodriguez, Juan; Sanchez-Paya, Jose; Luis Gomez, Juan; Hernandez, Jehovana; Remedios Aleman, Maria; del Mar Alonso, Maria; Inmaculada Hernandez, Maria; Diaz-Flores, Felicitas; Garcia, Dacil; Pelazas, Ricardo; Lopez Lirola, Ana; Sanz Moreno, Jose; Arranz Caso, Alberto; Hernandez Gutierrez, Cristina; Novella Mena, Maria; Pulido, Federico; Bisbal, Otilia; Hernando, Asuncion; Dominguez, Lourdes; Rial Crestelo, David; Bermejo, Laura; Santacreu, Mireia; Antonio Iribarrena, Jose; Arrizabalaga, Julio; Jose Aramburu, Maria; Camino, Xabier; Rodriguez-Arrondo, Francisco; Angel von Wichmann, Miguel; Pascual Tome, Lidia; Angel Goenaga, Miguel; Jesus Bustinduy, Ma; Azkune, Harkaitz; Ibarguren, Maialen; Lizardi, Aitziber; Kortajarena, Xabier; Masia, Mar; Padilla, Sergio; Navarro, Andres; Montolio, Fernando; Robledano, Catalina; Gregori Colome, Joan; Adsuar, Araceli; Pascual, Rafael; Fernandez, Marta; Garcia, Elena; Alberto Garcia, Jose; Barber, Xavier; Bernaldo de Quiros, Juan Carlos Lopez; Gutierrez, Isabel; Ramirez, Margarita; Padilla, Belen; Gijon, Paloma; Aldamiz-Echevarria, Teresa; Tejerina, Francisco; Jose Parras, Francisco; Balsalobre, Pascual; Diez, Cristina; Perez Latorre, Leire; Peraire, Joaquin; Vilades, Consuelo; Veloso, Sergio; Vargas, Montserrat; Lopez-Dupla, Miguel; Olona, Montserrat; Rull, Anna; Rodriguez-Gallego, Esther; Alba, Veronica; Montero Alonso, Marta; Lopez Aldeguer, Jose; Blanes Julia, Marino; Tasias Pitarch, Maria; Castro Hernandez, Ivan; Calabuig Munoz, Eva; Cuellar Tovar, Sandra; Salavert Lleti, Miguel; Fernandez Navarro, Juan; Miguel Molina, Jose; Gonzalez-garcia, Juan; Arnalich, Francisco; Ramon Arribas, Jose; Bernardino de la Serna, Jose Ignacio; Miguel Castro, Juan; Escosa, Luis; Herranz, Pedro; Hontanon, Victor; Garcia-Bujalance, Silvia; Garcia Lopez-Hortelano, Milagros; Gonzalez-Baeza, Alicia; Luz Martin-Carbonero, Maria; Mayoral, Mario; Jose Mellado, Maria; Esteban Mican, Rafael; Montejano, Rocio; Luisa Montes, Maria; Moreno, Victoria; Perez-Valero, Ignacio; Rodes, Berta; Sainz, Talia; Sendagorta, Elena; Stella Alcariz, Natalia; Valencia, Eulalia; Ramon Blanco, Jose; Antonio Oteo, Jose; Ibarra, Valvanera; Metola, Luis; Sanz, Mercedes; Perez-Martinez, Laura; Jaen, Angels; Sanmarti, Montse; Cairo, Mireia; Martinez-Lacasa, Javier; Velli, Pablo; Font, Roser; Xercavins, Mariona; Alonso, Noemi; Rivero, Maria; Reparaz, Jesus; Ruiz de Alda, Maria Gracia; de Leon Cano, Maria Teresa; Ruiz de Galarreta, Beatriz Pierola; de los Santos, Ignacio; Sanz Sanz, Jesus; Salas Aparicio, Ana; Sarria Cepeda, Cristina; Garcia-Fraile Fraile, Lucio; Martin Gayo, Enrique; Luis Casado, Jose; Dronda, Fernando; Moreno, Ana; Perez Elias, Maria Jesus; Gomez Ayerbe, Cristina; Gutierrez, Carolina; Madrid, Nadia; del Campo Terron, Santos; Marti, Paloma; Ansa, Uxua; Serrano, Sergio; Jesus Vivancos, Maria; Bernal, Enrique; Cano, Alfredo; Alcaraz Garcia, Antonia; Bravo Urbieta, Joaquin; Munoz, Angeles; Jose Alcaraz, Maria; del Carmen Villalba, Maria; Garciaa, Federico; Hernandez, Jose; Pena, Alejandro; Munoz, Leopoldo; Vinuesa, David; Martinez-Montes, Clara; Garcia, Fernando; Guerrero-Beltran, Carlos; Del Romero, Jorge; Rodriguez, Carmen; Puerta, Teresa; Carlos Carrio, Juan; Vera, Mar; Ballesteros, Juan; Ayerdi, Oskar; Antela, Antonio; Losada, Elena; Aguilera, Antonio; Riera, Melchor; Penaranda, Maria; Leyes, Maria; Angels Ribas, Ma; Campins, Antoni A.; Vidal, Carmen; Fanjul, Francisco; Murillas, Javier; Homar, Francisco; Santos, Jesus; Gomez Ayerbe, Crisitina; Viciana, Isabel; Palacios, Rosario; Maria Gonzalez, Carmen; Viciana, Pompeyo; Espinosa, Nuria; Fernando Lopez-Cortes, Luis; Podzamczer, Daniel; Ferrer, Elena; Imaz, Arkaitz; Tiraboschi, Juan; Silva, Ana; Saumoy, Maria; Olalla, Julian; del Arco, Alfonso; de la Torre, Javier; Luis Prada, Jose; de Lomas Guerrero, Jose Maria Garcia; Perez Stachowski, Javier; Amador, Concepcion; Juan Martinez, Onofre; Jesus Vera, Francisco; Martinez, Lorena; Garcia, Josefina; Alcaraz, Begona; Jimeno, Amaya; Castro Iglesias, Angeles; Pernas Souto, Berta; Mena de Cea, Alvaro; Galera, Carlos; Albendin, Helena; Perez, Aurora; Iborra, Asuncion; Moreno, Antonio; Angustias Merlos, Maria; Vidal, Asuncion; Suarez-Garcia, Ines; Malmierca, Eduardo; Gonzalez-Ruano, Patricia; Martin Rodrigo, Dolores; Omar Mohamed-Balghata, Mohamed; Gomez Vidal, Maria Amparo; Pineda, Juan A.; Macias, Juan; Bernal, Samuel; Thomson, Miguel; Delgado, Elena; Benito, Sonia; Montero, Vanessa;CoRIS
    Department: Medicina i Cirurgia
    URV's Author/s: Peraire Forner, José Joaquin
    Keywords: Crf02_ag Hiv-1 Infected patients coris Migration Molecular epidemiology Non-b subtypes Regional dispersal Spain Spanish cohort Spatiotemporal characteristics Spread
    Abstract: Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000-2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 279 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (t(MRCA)) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999-2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics.
    Thematic Areas: Astronomia / física Biodiversidade Biotecnología Ciência da computação Ciência de alimentos Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Engenharias i Engenharias ii Engenharias iii Ensino Farmacia Geociências Geografía Interdisciplinar Matemática / probabilidade e estatística Materiais Medicina i Medicina ii Medicina veterinaria Microbiology Microbiology (medical) Nutrição Odontología Química Saúde coletiva Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joaquim.peraire@urv.cat
    Author identifier: 0000-0001-7808-5479
    Record's date: 2023-05-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00370/full
    Papper original source: Frontiers In Microbiology. 10
    APA: Kostaki, Evangelia-Georgia; Flampouris, Andreas; Karamitros, Timokratis; Chueca, Natalia; Alvarez, Marta; Casas, Paz; Alejos, Belen; Hatzakis, Angelos (2019). Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions. Frontiers In Microbiology, 10(), -. DOI: 10.3389/fmicb.2019.00370
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3389/fmicb.2019.00370
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2019
    Publication Type: Journal Publications
  • Keywords:

    Microbiology,Microbiology (Medical)
    Crf02_ag
    Hiv-1
    Infected patients coris
    Migration
    Molecular epidemiology
    Non-b subtypes
    Regional dispersal
    Spain
    Spanish cohort
    Spatiotemporal characteristics
    Spread
    Astronomia / física
    Biodiversidade
    Biotecnología
    Ciência da computação
    Ciência de alimentos
    Ciências agrárias i
    Ciências ambientais
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Economia
    Engenharias i
    Engenharias ii
    Engenharias iii
    Ensino
    Farmacia
    Geociências
    Geografía
    Interdisciplinar
    Matemática / probabilidade e estatística
    Materiais
    Medicina i
    Medicina ii
    Medicina veterinaria
    Microbiology
    Microbiology (medical)
    Nutrição
    Odontología
    Química
    Saúde coletiva
    Zootecnia / recursos pesqueiros
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