Articles producció científica> Medicina i Cirurgia

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

  • Datos identificativos

    Identificador: imarina:9297697
    Autores:
    Kostaki, Evangelia-GeorgiaFlampouris, AndreasKaramitros, TimokratisChueca, NataliaAlvarez, MartaCasas, PazAlejos, BelenHatzakis, AngelosGarcia, FedericoParaskevis, DimitriosMoreno, SantiagoJarrin, InmaDalmau, DavidNavarro, Maria LuisaGonzalez, Maria IsabelBlanco, Jose LuisRubio, RafaelGutierrez, FelixVidal, FrancescBerenguer, JuanGonzalez, JuanHernando, VictoriaMoreno, CristinaIniesta, CarlosSousa, Luis Miguel GarciaPerez, Nieves SanzAngeles Munoz-Fernandez, M.Maria Garcia-Merino, IsabelConsuegra Fernandez, IreneGomez Rico, CoralGallego de la Fuente, JorgePalau Concejo, PaulaPortilla, JoaquinMerino, EsperanzaReus, SergioBoix, VicenteGiner, LiviaGadea, CarmenPortilla, IrenePampliega, MariaDiez, MarcosCarlos Rodriguez, JuanSanchez-Paya, JoseLuis Gomez, JuanHernandez, JehovanaRemedios Aleman, Mariadel Mar Alonso, MariaInmaculada Hernandez, MariaDiaz-Flores, FelicitasGarcia, DacilPelazas, RicardoLopez Lirola, AnaSanz Moreno, JoseArranz Caso, AlbertoHernandez Gutierrez, CristinaNovella Mena, MariaPulido, FedericoBisbal, OtiliaHernando, AsuncionDominguez, LourdesRial Crestelo, DavidBermejo, LauraSantacreu, MireiaAntonio Iribarrena, JoseArrizabalaga, JulioJose Aramburu, MariaCamino, XabierRodriguez-Arrondo, FranciscoAngel von Wichmann, MiguelPascual Tome, LidiaAngel Goenaga, MiguelJesus Bustinduy, MaAzkune, HarkaitzIbarguren, MaialenLizardi, AitziberKortajarena, XabierMasia, MarPadilla, SergioNavarro, AndresMontolio, FernandoRobledano, CatalinaGregori Colome, JoanAdsuar, AraceliPascual, RafaelFernandez, MartaGarcia, ElenaAlberto Garcia, JoseBarber, XavierBernaldo de Quiros, Juan Carlos LopezGutierrez,
    Resumen:
    Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000-2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 279 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (t(MRCA)) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999-2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced a
  • Otros:

    Autor según el artículo: Kostaki, Evangelia-Georgia; Flampouris, Andreas; Karamitros, Timokratis; Chueca, Natalia; Alvarez, Marta; Casas, Paz; Alejos, Belen; Hatzakis, Angelos; Garcia, Federico; Paraskevis, Dimitrios; Moreno, Santiago; Jarrin, Inma; Dalmau, David; Navarro, Maria Luisa; Gonzalez, Maria Isabel; Blanco, Jose Luis; Rubio, Rafael; Gutierrez, Felix; Vidal, Francesc; Berenguer, Juan; Gonzalez, Juan; Hernando, Victoria; Moreno, Cristina; Iniesta, Carlos; Sousa, Luis Miguel Garcia; Perez, Nieves Sanz; Angeles Munoz-Fernandez, M.; Maria Garcia-Merino, Isabel; Consuegra Fernandez, Irene; Gomez Rico, Coral; Gallego de la Fuente, Jorge; Palau Concejo, Paula; Portilla, Joaquin; Merino, Esperanza; Reus, Sergio; Boix, Vicente; Giner, Livia; Gadea, Carmen; Portilla, Irene; Pampliega, Maria; Diez, Marcos; Carlos Rodriguez, Juan; Sanchez-Paya, Jose; Luis Gomez, Juan; Hernandez, Jehovana; Remedios Aleman, Maria; del Mar Alonso, Maria; Inmaculada Hernandez, Maria; Diaz-Flores, Felicitas; Garcia, Dacil; Pelazas, Ricardo; Lopez Lirola, Ana; Sanz Moreno, Jose; Arranz Caso, Alberto; Hernandez Gutierrez, Cristina; Novella Mena, Maria; Pulido, Federico; Bisbal, Otilia; Hernando, Asuncion; Dominguez, Lourdes; Rial Crestelo, David; Bermejo, Laura; Santacreu, Mireia; Antonio Iribarrena, Jose; Arrizabalaga, Julio; Jose Aramburu, Maria; Camino, Xabier; Rodriguez-Arrondo, Francisco; Angel von Wichmann, Miguel; Pascual Tome, Lidia; Angel Goenaga, Miguel; Jesus Bustinduy, Ma; Azkune, Harkaitz; Ibarguren, Maialen; Lizardi, Aitziber; Kortajarena, Xabier; Masia, Mar; Padilla, Sergio; Navarro, Andres; Montolio, Fernando; Robledano, Catalina; Gregori Colome, Joan; Adsuar, Araceli; Pascual, Rafael; Fernandez, Marta; Garcia, Elena; Alberto Garcia, Jose; Barber, Xavier; Bernaldo de Quiros, Juan Carlos Lopez; Gutierrez, Isabel; Ramirez, Margarita; Padilla, Belen; Gijon, Paloma; Aldamiz-Echevarria, Teresa; Tejerina, Francisco; Jose Parras, Francisco; Balsalobre, Pascual; Diez, Cristina; Perez Latorre, Leire; Peraire, Joaquin; Vilades, Consuelo; Veloso, Sergio; Vargas, Montserrat; Lopez-Dupla, Miguel; Olona, Montserrat; Rull, Anna; Rodriguez-Gallego, Esther; Alba, Veronica; Montero Alonso, Marta; Lopez Aldeguer, Jose; Blanes Julia, Marino; Tasias Pitarch, Maria; Castro Hernandez, Ivan; Calabuig Munoz, Eva; Cuellar Tovar, Sandra; Salavert Lleti, Miguel; Fernandez Navarro, Juan; Miguel Molina, Jose; Gonzalez-garcia, Juan; Arnalich, Francisco; Ramon Arribas, Jose; Bernardino de la Serna, Jose Ignacio; Miguel Castro, Juan; Escosa, Luis; Herranz, Pedro; Hontanon, Victor; Garcia-Bujalance, Silvia; Garcia Lopez-Hortelano, Milagros; Gonzalez-Baeza, Alicia; Luz Martin-Carbonero, Maria; Mayoral, Mario; Jose Mellado, Maria; Esteban Mican, Rafael; Montejano, Rocio; Luisa Montes, Maria; Moreno, Victoria; Perez-Valero, Ignacio; Rodes, Berta; Sainz, Talia; Sendagorta, Elena; Stella Alcariz, Natalia; Valencia, Eulalia; Ramon Blanco, Jose; Antonio Oteo, Jose; Ibarra, Valvanera; Metola, Luis; Sanz, Mercedes; Perez-Martinez, Laura; Jaen, Angels; Sanmarti, Montse; Cairo, Mireia; Martinez-Lacasa, Javier; Velli, Pablo; Font, Roser; Xercavins, Mariona; Alonso, Noemi; Rivero, Maria; Reparaz, Jesus; Ruiz de Alda, Maria Gracia; de Leon Cano, Maria Teresa; Ruiz de Galarreta, Beatriz Pierola; de los Santos, Ignacio; Sanz Sanz, Jesus; Salas Aparicio, Ana; Sarria Cepeda, Cristina; Garcia-Fraile Fraile, Lucio; Martin Gayo, Enrique; Luis Casado, Jose; Dronda, Fernando; Moreno, Ana; Perez Elias, Maria Jesus; Gomez Ayerbe, Cristina; Gutierrez, Carolina; Madrid, Nadia; del Campo Terron, Santos; Marti, Paloma; Ansa, Uxua; Serrano, Sergio; Jesus Vivancos, Maria; Bernal, Enrique; Cano, Alfredo; Alcaraz Garcia, Antonia; Bravo Urbieta, Joaquin; Munoz, Angeles; Jose Alcaraz, Maria; del Carmen Villalba, Maria; Garciaa, Federico; Hernandez, Jose; Pena, Alejandro; Munoz, Leopoldo; Vinuesa, David; Martinez-Montes, Clara; Garcia, Fernando; Guerrero-Beltran, Carlos; Del Romero, Jorge; Rodriguez, Carmen; Puerta, Teresa; Carlos Carrio, Juan; Vera, Mar; Ballesteros, Juan; Ayerdi, Oskar; Antela, Antonio; Losada, Elena; Aguilera, Antonio; Riera, Melchor; Penaranda, Maria; Leyes, Maria; Angels Ribas, Ma; Campins, Antoni A.; Vidal, Carmen; Fanjul, Francisco; Murillas, Javier; Homar, Francisco; Santos, Jesus; Gomez Ayerbe, Crisitina; Viciana, Isabel; Palacios, Rosario; Maria Gonzalez, Carmen; Viciana, Pompeyo; Espinosa, Nuria; Fernando Lopez-Cortes, Luis; Podzamczer, Daniel; Ferrer, Elena; Imaz, Arkaitz; Tiraboschi, Juan; Silva, Ana; Saumoy, Maria; Olalla, Julian; del Arco, Alfonso; de la Torre, Javier; Luis Prada, Jose; de Lomas Guerrero, Jose Maria Garcia; Perez Stachowski, Javier; Amador, Concepcion; Juan Martinez, Onofre; Jesus Vera, Francisco; Martinez, Lorena; Garcia, Josefina; Alcaraz, Begona; Jimeno, Amaya; Castro Iglesias, Angeles; Pernas Souto, Berta; Mena de Cea, Alvaro; Galera, Carlos; Albendin, Helena; Perez, Aurora; Iborra, Asuncion; Moreno, Antonio; Angustias Merlos, Maria; Vidal, Asuncion; Suarez-Garcia, Ines; Malmierca, Eduardo; Gonzalez-Ruano, Patricia; Martin Rodrigo, Dolores; Omar Mohamed-Balghata, Mohamed; Gomez Vidal, Maria Amparo; Pineda, Juan A.; Macias, Juan; Bernal, Samuel; Thomson, Miguel; Delgado, Elena; Benito, Sonia; Montero, Vanessa;CoRIS
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Peraire Forner, José Joaquin / RULL AIXA, ANNA / Veloso Esteban, Sergio
    Palabras clave: Spread Spatiotemporal characteristics Spanish cohort Spain Regional dispersal Non-b subtypes Molecular epidemiology Migration Infected patients coris Hiv-1 Crf02_ag
    Resumen: Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000-2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 279 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (t(MRCA)) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999-2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics.
    Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Microbiology (medical) Microbiology Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências Farmacia Ensino Engenharias iii Engenharias ii Engenharias i Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: sergio.veloso@urv.cat joaquim.peraire@urv.cat
    Identificador del autor: 0000-0001-7808-5479
    Fecha de alta del registro: 2024-01-13
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fmicb.2019.00370/full
    Referencia al articulo segun fuente origial: Frontiers In Microbiology. 10
    Referencia de l'ítem segons les normes APA: Kostaki, Evangelia-Georgia; Flampouris, Andreas; Karamitros, Timokratis; Chueca, Natalia; Alvarez, Marta; Casas, Paz; Alejos, Belen; Hatzakis, Angelos (2019). Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions. Frontiers In Microbiology, 10(), -. DOI: 10.3389/fmicb.2019.00370
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3389/fmicb.2019.00370
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2019
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Microbiology,Microbiology (Medical)
    Spread
    Spatiotemporal characteristics
    Spanish cohort
    Spain
    Regional dispersal
    Non-b subtypes
    Molecular epidemiology
    Migration
    Infected patients coris
    Hiv-1
    Crf02_ag
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Microbiology (medical)
    Microbiology
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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