Author, as appears in the article.: Gao, Juntao Tony; Guimera, Roger; Li, Hua; Pinto, Ines Mendes; Sales-Pardo, Marta; Wai, Stephanie C; Rubinstein, Boris; Li, Rong
Department: Enginyeria Química
URV's Author/s: Guimera Manrique, Roger / Sales Pardo, Marta
Keywords: Sites Polarization Organization Network modularity Morphogenesis Modeling Localization Growth Components Complex Budding yeast
Abstract: In this study, we investigated on a systems level how complex protein interactions underlying cell polarity in yeast determine the dynamic association of proteins with the polar cortical domain (PCD) where they localize and perform morphogenetic functions. We constructed a network of physical interactions among > 100 proteins localized to the PCD. This network was further divided into five robust modules correlating with distinct subprocesses associated with cell polarity. Based on this reconstructed network, we proposed a simple model that approximates a PCD protein's molecular residence time as the sumof the characteristic time constants of the functional modules with which it interacts, weighted by the number of edges forming these interactions. Regression analyses showed excellent fitting of the model with experimentally measured residence times for a large subset of the PCD proteins. The model is able to predict residence times using small training sets. Our analysis also revealed a scaffold protein that imposes a local constraint of dynamics for certain interacting proteins.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências General o multidisciplinar Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia Anthropology
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: roger.guimera@urv.cat marta.sales@urv.cat
Author identifier: 0000-0002-3597-4310 0000-0002-8140-6525
Record's date: 2024-10-19
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.pnas.org/doi/abs/10.1073/pnas.1017567108
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Proceedings Of The National Academy Of Sciences Of The United States Of America. 108 (18): 7647-7652
APA: Gao, Juntao Tony; Guimera, Roger; Li, Hua; Pinto, Ines Mendes; Sales-Pardo, Marta; Wai, Stephanie C; Rubinstein, Boris; Li, Rong (2011). Modular coherence of protein dynamics in yeast cell polarity system. Proceedings Of The National Academy Of Sciences Of The United States Of America, 108(18), 7647-7652. DOI: 10.1073/pnas.1017567108
Article's DOI: 10.1073/pnas.1017567108
Entity: Universitat Rovira i Virgili
Journal publication year: 2011
Publication Type: Journal Publications