Articles producció científica> Enginyeria Química

Modular coherence of protein dynamics in yeast cell polarity system

  • Identification data

    Identifier: imarina:9298193
  • Authors:

    Gao, Juntao Tony
    Guimera, Roger
    Li, Hua
    Pinto, Ines Mendes
    Sales-Pardo, Marta
    Wai, Stephanie C.
    Rubinstein, Boris
    Li, Rong
  • Others:

    Author, as appears in the article.: Gao, Juntao Tony; Guimera, Roger; Li, Hua; Pinto, Ines Mendes; Sales-Pardo, Marta; Wai, Stephanie C.; Rubinstein, Boris; Li, Rong;
    Department: Enginyeria Química
    URV's Author/s: Guimera Manrique, Roger / Sales Pardo, Marta
    Keywords: Sites Polarization Organization Network modularity Morphogenesis Modeling Localization Growth Components Complex Budding yeast
    Abstract: In this study, we investigated on a systems level how complex protein interactions underlying cell polarity in yeast determine the dynamic association of proteins with the polar cortical domain (PCD) where they localize and perform morphogenetic functions. We constructed a network of physical interactions among > 100 proteins localized to the PCD. This network was further divided into five robust modules correlating with distinct subprocesses associated with cell polarity. Based on this reconstructed network, we proposed a simple model that approximates a PCD protein's molecular residence time as the sumof the characteristic time constants of the functional modules with which it interacts, weighted by the number of edges forming these interactions. Regression analyses showed excellent fitting of the model with experimentally measured residence times for a large subset of the PCD proteins. The model is able to predict residence times using small training sets. Our analysis also revealed a scaffold protein that imposes a local constraint of dynamics for certain interacting proteins.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências General o multidisciplinar Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia Anthropology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: roger.guimera@urv.cat marta.sales@urv.cat
    Author identifier: 0000-0002-3597-4310 0000-0002-8140-6525
    Record's date: 2023-05-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.pnas.org/doi/abs/10.1073/pnas.1017567108
    Papper original source: Proceedings Of The National Academy Of Sciences Of The United States Of America. 108 (18): 7647-7652
    APA: Gao, Juntao Tony; Guimera, Roger; Li, Hua; Pinto, Ines Mendes; Sales-Pardo, Marta; Wai, Stephanie C.; Rubinstein, Boris; Li, Rong; (2011). Modular coherence of protein dynamics in yeast cell polarity system. Proceedings Of The National Academy Of Sciences Of The United States Of America, 108(18), 7647-7652. DOI: 10.1073/pnas.1017567108
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1073/pnas.1017567108
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2011
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Sites
    Polarization
    Organization
    Network modularity
    Morphogenesis
    Modeling
    Localization
    Growth
    Components
    Complex
    Budding yeast
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Matemática / probabilidade e estatística
    Interdisciplinar
    Geografía
    Geociências
    General o multidisciplinar
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação física
    Ciencias sociales
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Antropologia / arqueologia
    Anthropology
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