Autor según el artículo: Gao, Juntao Tony; Guimera, Roger; Li, Hua; Pinto, Ines Mendes; Sales-Pardo, Marta; Wai, Stephanie C; Rubinstein, Boris; Li, Rong
Departamento: Enginyeria Química
Autor/es de la URV: Guimera Manrique, Roger / Sales Pardo, Marta
Palabras clave: Sites Polarization Organization Network modularity Morphogenesis Modeling Localization Growth Components Complex Budding yeast
Resumen: In this study, we investigated on a systems level how complex protein interactions underlying cell polarity in yeast determine the dynamic association of proteins with the polar cortical domain (PCD) where they localize and perform morphogenetic functions. We constructed a network of physical interactions among > 100 proteins localized to the PCD. This network was further divided into five robust modules correlating with distinct subprocesses associated with cell polarity. Based on this reconstructed network, we proposed a simple model that approximates a PCD protein's molecular residence time as the sumof the characteristic time constants of the functional modules with which it interacts, weighted by the number of edges forming these interactions. Regression analyses showed excellent fitting of the model with experimentally measured residence times for a large subset of the PCD proteins. The model is able to predict residence times using small training sets. Our analysis also revealed a scaffold protein that imposes a local constraint of dynamics for certain interacting proteins.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Geografía Geociências General o multidisciplinar Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência da computação Biotecnología Biodiversidade Astronomia / física Antropologia / arqueologia Anthropology
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: roger.guimera@urv.cat marta.sales@urv.cat
Identificador del autor: 0000-0002-3597-4310 0000-0002-8140-6525
Fecha de alta del registro: 2024-10-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.pnas.org/doi/abs/10.1073/pnas.1017567108
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Proceedings Of The National Academy Of Sciences Of The United States Of America. 108 (18): 7647-7652
Referencia de l'ítem segons les normes APA: Gao, Juntao Tony; Guimera, Roger; Li, Hua; Pinto, Ines Mendes; Sales-Pardo, Marta; Wai, Stephanie C; Rubinstein, Boris; Li, Rong (2011). Modular coherence of protein dynamics in yeast cell polarity system. Proceedings Of The National Academy Of Sciences Of The United States Of America, 108(18), 7647-7652. DOI: 10.1073/pnas.1017567108
DOI del artículo: 10.1073/pnas.1017567108
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2011
Tipo de publicación: Journal Publications