Author, as appears in the article.: Guma, J; Palazon-Carrion, N; Rueda-Dominguez, A; Sequero, S; Calvo, V; Garcia-Arroyo, R; Gomez-Codina, J; Llanos, M; Martinez-Banaclocha, N; Provencio, M
Department: Medicina i Cirurgia
URV's Author/s: Gumà Padró, José
Keywords: Treatment Non-hodgkin-lymphoma Guideline Diffuse large b-cell lymphoma Diagnosis treatment single-arm r-chop plus rituximab phase-3 open-label multicenter guideline epoch-r elderly-patients diagnosis chemotherapy
Abstract: Diffuse large B-cell lymphoma is the most frequent histological subtype of NHL and the paradigm for the management of aggressive lymphoma. An excisional or incisional lymph node biopsy evaluated by an experienced hemopathologist is recommended to establish the diagnosis. Twenty years following its introduction, R-CHOP remains the standard first-line treatment. No modification of this scheme (increased chemotherapy dose intensity, new monoclonal antibodies, or the addition of immunomodulators or anti-target agents) has significatively improved the clinical outcomes, whereas therapy for recurrence or progression is evolving rapidly. The irruption of CART cells, polatuzumab vedotin, tafasitamab, and CD20/CD3 bispecific antibodies are changing the natural history of relapsed patients and will challenge R-CHOP as the benchmark for newly diagnosed patients.© 2023. The Author(s).
Thematic Areas: Saúde coletiva Oncology Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Farmacia Engenharias ii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jose.guma@urv.cat
Author identifier: 0000-0001-7541-9832
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Clinical & Translational Oncology. 25 (9): 2749-2758
APA: Guma, J; Palazon-Carrion, N; Rueda-Dominguez, A; Sequero, S; Calvo, V; Garcia-Arroyo, R; Gomez-Codina, J; Llanos, M; Martinez-Banaclocha, N; Provencio (2023). SEOM-GOTEL clinical guidelines on diffuse large B cell lymphoma (2022). Clinical & Translational Oncology, 25(9), 2749-2758. DOI: 10.1007/s12094-023-03206-5
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV