Autor según el artículo: Guma, J; Palazon-Carrion, N; Rueda-Dominguez, A; Sequero, S; Calvo, V; Garcia-Arroyo, R; Gomez-Codina, J; Llanos, M; Martinez-Banaclocha, N; Provencio, M
Departamento: Medicina i Cirurgia
Autor/es de la URV: Gumà Padró, José
Palabras clave: Treatment Non-hodgkin-lymphoma Guideline Diffuse large b-cell lymphoma Diagnosis treatment single-arm r-chop plus rituximab phase-3 open-label multicenter guideline epoch-r elderly-patients diagnosis chemotherapy
Resumen: Diffuse large B-cell lymphoma is the most frequent histological subtype of NHL and the paradigm for the management of aggressive lymphoma. An excisional or incisional lymph node biopsy evaluated by an experienced hemopathologist is recommended to establish the diagnosis. Twenty years following its introduction, R-CHOP remains the standard first-line treatment. No modification of this scheme (increased chemotherapy dose intensity, new monoclonal antibodies, or the addition of immunomodulators or anti-target agents) has significatively improved the clinical outcomes, whereas therapy for recurrence or progression is evolving rapidly. The irruption of CART cells, polatuzumab vedotin, tafasitamab, and CD20/CD3 bispecific antibodies are changing the natural history of relapsed patients and will challenge R-CHOP as the benchmark for newly diagnosed patients.© 2023. The Author(s).
Áreas temáticas: Saúde coletiva Oncology Odontología Medicine (miscellaneous) Medicina veterinaria Medicina ii Medicina i Farmacia Engenharias ii Ciências biológicas ii Ciências biológicas i Cancer research Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: jose.guma@urv.cat
Identificador del autor: 0000-0001-7541-9832
Fecha de alta del registro: 2024-08-03
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://link.springer.com/article/10.1007/s12094-023-03206-5
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Clinical & Translational Oncology. 25 (9): 2749-2758
Referencia de l'ítem segons les normes APA: Guma, J; Palazon-Carrion, N; Rueda-Dominguez, A; Sequero, S; Calvo, V; Garcia-Arroyo, R; Gomez-Codina, J; Llanos, M; Martinez-Banaclocha, N; Provencio (2023). SEOM-GOTEL clinical guidelines on diffuse large B cell lymphoma (2022). Clinical & Translational Oncology, 25(9), 2749-2758. DOI: 10.1007/s12094-023-03206-5
DOI del artículo: 10.1007/s12094-023-03206-5
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV