Author, as appears in the article.: Bertran, L; Capellades, J; Abelló, S; Durán-Bertran, J; Aguilar, C; Martinez, S; Sabench, F; Correig, X; Yanes, O; Auguet, T; Richart, C
Department: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
URV's Author/s: ABELLÓ CROS, SÒNIA / Aguilar Crespillo, Carmen Isabel / Alkhoury, Nadine / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Correig Blanchar, Francesc Xavier / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima / Yanes Torrado, Óscar
Keywords: Signature Roles Phosphatidylcholine Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Morbid obesity Metabolomics Lipidomics Lipid-accumulation Inhibition Health Fatty liver-disease Epidemiology Ceramides Acid-metabolism
Abstract: This study investigated the importance of a metabolomic analysis in a complex disease such as nonalcoholic steatohepatitis (NASH) associated with obesity. Using an untargeted metabolomics technique, we studied blood metabolites in 216 morbidly obese women with liver histological diagnosis. A total of 172 patients were diagnosed with nonalcoholic fatty liver disease (NAFLD), and 44 were diagnosed with normal liver (NL). Patients with NAFLD were classified into simple steatosis (n = 66) and NASH (n = 106) categories. A comparative analysis of metabolites levels between NASH and NL demonstrated significant differences in lipid metabolites and derivatives, mainly from the phospholipid group. In NASH, there were increased levels of several phosphatidylinositols and phosphatidylethanolamines, as well as isolated metabolites such as diacylglycerol 34:1, lyso-phosphatidylethanolamine 20:3 and sphingomyelin 38:1. By contrast, there were decreased levels of acylcarnitines, sphingomyelins and linoleic acid. These findings may facilitate identification studies of the main pathogenic metabolic pathways related to NASH and may also have a possible applicability in a panel of metabolites to be used as biomarkers in future algorithms of the disease diagnosis and its follow-up. Further confirmatory studies in groups with different ages and sexes are necessary.
Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: oscar.yanes@urv.cat cristobalmanuel.richart@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat xavier.correig@urv.cat fatima.sabench@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat
Author identifier: 0000-0003-3695-7157 0000-0003-0852-6739 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X 0000-0002-6902-3054 0000-0002-9262-8756 0000-0001-9052-1368 0000-0001-9052-1368
Record's date: 2024-01-14
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/1422-0067/24/12/9789
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: International Journal Of Molecular Sciences. 24 (12):
APA: Bertran, L; Capellades, J; Abelló, S; Durán-Bertran, J; Aguilar, C; Martinez, S; Sabench, F; Correig, X; Yanes, O; Auguet, T; Richart, C (2023). LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity. International Journal Of Molecular Sciences, 24(12), -. DOI: 10.3390/ijms24129789
Article's DOI: 10.3390/ijms24129789
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV