Articles producció científica> Medicina i Cirurgia

LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity

  • Datos identificativos

    Identificador: imarina:9325516
    Autores:
    Bertran, LaiaCapellades, JordiAbello, SoniaDuran-Bertran, JoanAguilar, CarmenMartinez, SalomeSabench, FatimaCorreig, XavierYanes, OscarAuguet, TeresaRichart, Cristobal
    Resumen:
    This study investigated the importance of a metabolomic analysis in a complex disease such as nonalcoholic steatohepatitis (NASH) associated with obesity. Using an untargeted metabolomics technique, we studied blood metabolites in 216 morbidly obese women with liver histological diagnosis. A total of 172 patients were diagnosed with nonalcoholic fatty liver disease (NAFLD), and 44 were diagnosed with normal liver (NL). Patients with NAFLD were classified into simple steatosis (n = 66) and NASH (n = 106) categories. A comparative analysis of metabolites levels between NASH and NL demonstrated significant differences in lipid metabolites and derivatives, mainly from the phospholipid group. In NASH, there were increased levels of several phosphatidylinositols and phosphatidylethanolamines, as well as isolated metabolites such as diacylglycerol 34:1, lyso-phosphatidylethanolamine 20:3 and sphingomyelin 38:1. By contrast, there were decreased levels of acylcarnitines, sphingomyelins and linoleic acid. These findings may facilitate identification studies of the main pathogenic metabolic pathways related to NASH and may also have a possible applicability in a panel of metabolites to be used as biomarkers in future algorithms of the disease diagnosis and its follow-up. Further confirmatory studies in groups with different ages and sexes are necessary.
  • Otros:

    Autor según el artículo: Bertran, Laia; Capellades, Jordi; Abello, Sonia; Duran-Bertran, Joan; Aguilar, Carmen; Martinez, Salome; Sabench, Fatima; Correig, Xavier; Yanes, Oscar; Auguet, Teresa; Richart, Cristobal
    Departamento: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
    Autor/es de la URV: ABELLÓ CROS, SÒNIA / Aguilar Crespillo, Carmen Isabel / Alkhoury, Nadine / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Correig Blanchar, Francesc Xavier / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima / Yanes Torrado, Óscar
    Palabras clave: Signature Roles Phosphatidylcholine Obesity, morbid Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Non-alcoholic fatty liver disease Morbid obesity Metabolomics Liver Lipidomics Lipid-accumulation Inhibition Humans Health Female Fatty liver-disease Epidemiology Ceramides Biomarkers Acid-metabolism
    Resumen: This study investigated the importance of a metabolomic analysis in a complex disease such as nonalcoholic steatohepatitis (NASH) associated with obesity. Using an untargeted metabolomics technique, we studied blood metabolites in 216 morbidly obese women with liver histological diagnosis. A total of 172 patients were diagnosed with nonalcoholic fatty liver disease (NAFLD), and 44 were diagnosed with normal liver (NL). Patients with NAFLD were classified into simple steatosis (n = 66) and NASH (n = 106) categories. A comparative analysis of metabolites levels between NASH and NL demonstrated significant differences in lipid metabolites and derivatives, mainly from the phospholipid group. In NASH, there were increased levels of several phosphatidylinositols and phosphatidylethanolamines, as well as isolated metabolites such as diacylglycerol 34:1, lyso-phosphatidylethanolamine 20:3 and sphingomyelin 38:1. By contrast, there were decreased levels of acylcarnitines, sphingomyelins and linoleic acid. These findings may facilitate identification studies of the main pathogenic metabolic pathways related to NASH and may also have a possible applicability in a panel of metabolites to be used as biomarkers in future algorithms of the disease diagnosis and its follow-up. Further confirmatory studies in groups with different ages and sexes are necessary.
    Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: oscar.yanes@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat xavier.correig@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
    Identificador del autor: 0000-0003-3695-7157 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-6902-3054 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
    Fecha de alta del registro: 2024-09-28
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 24 (12): 9789-
    Referencia de l'ítem segons les normes APA: Bertran, Laia; Capellades, Jordi; Abello, Sonia; Duran-Bertran, Joan; Aguilar, Carmen; Martinez, Salome; Sabench, Fatima; Correig, Xavier; Yanes, Osca (2023). LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity. International Journal Of Molecular Sciences, 24(12), 9789-. DOI: 10.3390/ijms24129789
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2023
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Signature
    Roles
    Phosphatidylcholine
    Obesity, morbid
    Nonalcoholic steatohepatitis
    Nonalcoholic fatty liver disease
    Non-alcoholic fatty liver disease
    Morbid obesity
    Metabolomics
    Liver
    Lipidomics
    Lipid-accumulation
    Inhibition
    Humans
    Health
    Female
    Fatty liver-disease
    Epidemiology
    Ceramides
    Biomarkers
    Acid-metabolism
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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