Autor según el artículo: Bertran, Laia; Capellades, Jordi; Abello, Sonia; Duran-Bertran, Joan; Aguilar, Carmen; Martinez, Salome; Sabench, Fatima; Correig, Xavier; Yanes, Oscar; Auguet, Teresa; Richart, Cristobal
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica Medicina i Cirurgia
Autor/es de la URV: ABELLÓ CROS, SÒNIA / Aguilar Crespillo, Carmen Isabel / Alkhoury, Nadine / Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Correig Blanchar, Francesc Xavier / Richart Jurado, Cristobal Manuel / Sabench Pereferrer, Fàtima / Yanes Torrado, Óscar
Palabras clave: Signature Roles Phosphatidylcholine Obesity, morbid Nonalcoholic steatohepatitis Nonalcoholic fatty liver disease Non-alcoholic fatty liver disease Morbid obesity Metabolomics Liver Lipidomics Lipid-accumulation Inhibition Humans Health Female Fatty liver-disease Epidemiology Ceramides Biomarkers Acid-metabolism
Resumen: This study investigated the importance of a metabolomic analysis in a complex disease such as nonalcoholic steatohepatitis (NASH) associated with obesity. Using an untargeted metabolomics technique, we studied blood metabolites in 216 morbidly obese women with liver histological diagnosis. A total of 172 patients were diagnosed with nonalcoholic fatty liver disease (NAFLD), and 44 were diagnosed with normal liver (NL). Patients with NAFLD were classified into simple steatosis (n = 66) and NASH (n = 106) categories. A comparative analysis of metabolites levels between NASH and NL demonstrated significant differences in lipid metabolites and derivatives, mainly from the phospholipid group. In NASH, there were increased levels of several phosphatidylinositols and phosphatidylethanolamines, as well as isolated metabolites such as diacylglycerol 34:1, lyso-phosphatidylethanolamine 20:3 and sphingomyelin 38:1. By contrast, there were decreased levels of acylcarnitines, sphingomyelins and linoleic acid. These findings may facilitate identification studies of the main pathogenic metabolic pathways related to NASH and may also have a possible applicability in a panel of metabolites to be used as biomarkers in future algorithms of the disease diagnosis and its follow-up. Further confirmatory studies in groups with different ages and sexes are necessary.
Áreas temáticas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: oscar.yanes@urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat nadine.alkhoury@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat xavier.correig@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
Identificador del autor: 0000-0003-3695-7157 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-6902-3054 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
Fecha de alta del registro: 2024-09-28
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: International Journal Of Molecular Sciences. 24 (12): 9789-
Referencia de l'ítem segons les normes APA: Bertran, Laia; Capellades, Jordi; Abello, Sonia; Duran-Bertran, Joan; Aguilar, Carmen; Martinez, Salome; Sabench, Fatima; Correig, Xavier; Yanes, Osca (2023). LC/MS-Based Untargeted Metabolomics Study in Women with Nonalcoholic Steatohepatitis Associated with Morbid Obesity. International Journal Of Molecular Sciences, 24(12), 9789-. DOI: 10.3390/ijms24129789
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications