Author, as appears in the article.: Fontanals N; Pocurull E; Montes R; González-Mariño I; Santana-Viera S; Miró M; Rico A; Rodríguez-Mozaz S; Borrull F; Benito Quintana J; Maria Marcé R
Department: Química Analítica i Química Orgànica
URV's Author/s: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria / Pocurull Aixala, Eva
Keywords: Wastewater-based epidemiology Solid-phase extraction Pharmaceuticals Metabolites Liquid chromatography-tandem mass spectrometry Influent wastewater wastewater-based epidemiology solid-phase extraction products liquid chromatography-tandem mass spectrometry influent wastewater illicit epidemiology environment biomarkers
Abstract: The occurrence of pharmaceuticals in influent wastewater samples (IWW) is a recurrent issue. The monitoring of their presence is not only valuable from an environmental point of view, but also as a tool to analyze patterns of human use by the so-called wastewater-based epidemiology. The development of an analytical method based on solid-phase extraction followed by liquid chromatography coupled to tandem mass spectrometry to monitor the occurrence of a group of seventeen pharmaceuticals including the most representative for various therapeutic families in IWW samples is described in this work. The samples were collected during a monitoring week in six wastewater treatment plants located in different cities and towns across Spain. The developed method provides acceptable figures of merit with apparent recoveries in IWW ranging from 42% to 139%, and low matrix effect (in general lower than ± 30%), and method quantification limits (MQL) between 1 ng/L and 24 ng/L for all compounds, except atenolol (58 ng/L). All the studied pharmaceuticals were found in all samples with concentrations ranging from < MQL to 10,393 ng/L, being the highest concentrations for tramadol. The population normalized daily loads revealed that the use of pharmaceuticals follows, in general, a similar pattern in all cities monitored.
Thematic Areas: Spectroscopy Saúde coletiva Química Odontología Nutrição Medicina ii Medicina i Materiais Interdisciplinar Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nuria.fontanals@urv.cat nuria.fontanals@urv.cat eva.pocurull@urv.cat rosamaria.marce@urv.cat francesc.borrull@urv.cat
Author identifier: 0000-0002-7534-1964 0000-0002-7534-1964 0000-0001-5123-995X 0000-0002-5667-2899 0000-0003-2718-9336
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0026265X23007506?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Microchemical Journal. 193
APA: Fontanals N; Pocurull E; Montes R; González-Mariño I; Santana-Viera S; Miró M; Rico A; Rodríguez-Mozaz S; Borrull F; Benito Quintana J; Maria Marcé R (2023). A new analytical method to determine trace level concentrations of pharmaceuticals in influent wastewater: A tool to monitor human use patterns. Microchemical Journal, 193(), -. DOI: 10.1016/j.microc.2023.109131
Article's DOI: 10.1016/j.microc.2023.109131
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications