Autor según el artículo: Fontanals N; Pocurull E; Montes R; González-Mariño I; Santana-Viera S; Miró M; Rico A; Rodríguez-Mozaz S; Borrull F; Benito Quintana J; Maria Marcé R
Departamento: Química Analítica i Química Orgànica
Autor/es de la URV: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria / Pocurull Aixala, Eva
Palabras clave: Wastewater-based epidemiology Solid-phase extraction Pharmaceuticals Metabolites Liquid chromatography-tandem mass spectrometry Influent wastewater wastewater-based epidemiology solid-phase extraction products liquid chromatography-tandem mass spectrometry influent wastewater illicit epidemiology environment biomarkers
Resumen: The occurrence of pharmaceuticals in influent wastewater samples (IWW) is a recurrent issue. The monitoring of their presence is not only valuable from an environmental point of view, but also as a tool to analyze patterns of human use by the so-called wastewater-based epidemiology. The development of an analytical method based on solid-phase extraction followed by liquid chromatography coupled to tandem mass spectrometry to monitor the occurrence of a group of seventeen pharmaceuticals including the most representative for various therapeutic families in IWW samples is described in this work. The samples were collected during a monitoring week in six wastewater treatment plants located in different cities and towns across Spain. The developed method provides acceptable figures of merit with apparent recoveries in IWW ranging from 42% to 139%, and low matrix effect (in general lower than ± 30%), and method quantification limits (MQL) between 1 ng/L and 24 ng/L for all compounds, except atenolol (58 ng/L). All the studied pharmaceuticals were found in all samples with concentrations ranging from < MQL to 10,393 ng/L, being the highest concentrations for tramadol. The population normalized daily loads revealed that the use of pharmaceuticals follows, in general, a similar pattern in all cities monitored.
Áreas temáticas: Spectroscopy Saúde coletiva Química Odontología Nutrição Medicina ii Medicina i Materiais Interdisciplinar Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, analytical Biotecnología Biodiversidade Astronomia / física Analytical chemistry Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: francesc.borrull@urv.cat rosamaria.marce@urv.cat eva.pocurull@urv.cat nuria.fontanals@urv.cat nuria.fontanals@urv.cat
Identificador del autor: 0000-0003-2718-9336 0000-0002-5667-2899 0000-0001-5123-995X 0000-0002-7534-1964 0000-0002-7534-1964
Fecha de alta del registro: 2024-06-08
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/pii/S0026265X23007506?via%3Dihub
URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Microchemical Journal. 193
Referencia de l'ítem segons les normes APA: Fontanals N; Pocurull E; Montes R; González-Mariño I; Santana-Viera S; Miró M; Rico A; Rodríguez-Mozaz S; Borrull F; Benito Quintana J; Maria Marcé R (2023). A new analytical method to determine trace level concentrations of pharmaceuticals in influent wastewater: A tool to monitor human use patterns. Microchemical Journal, 193(), -. DOI: 10.1016/j.microc.2023.109131
DOI del artículo: 10.1016/j.microc.2023.109131
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2023
Tipo de publicación: Journal Publications
Repositori URV