Author, as appears in the article.: Llop, D; Feliu, A; Ibarretxe, D; Escribano, J; Plana, N; Borjabad-Rodriguez, C; Masana, L; Vallve, J C
Department: Medicina i Cirurgia
URV's Author/s: Escribano Subías, Joaquín / Feliu Rovira, Albert / Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia / Vallvé Torrente, Joan Carles
Keywords: Risk factors Pulse wave analysis Proton magnetic resonance spectroscopy Lipoprotein profile Intima-media thickness Hyperlipoproteinemia type ii Humans Familiar hypercholesterolemia Familiar hyper Cross-sectional studies Cholesterol, ldl Children Child Carotid intima-media thickness Body mass index Blood pressure Arterial stiffness Arterial injury susceptibility subclinical atherosclerosis size pulse-wave velocity particle number low-density-lipoprotein lipoprotein pro file disease children cardiovascular risk arterial stiffness arterial injury
Abstract: Children with familial hypercholesterolaemia (FH) have elevated low-density lipoprotein cholesterol (LDL-C) concentrations since birth, which increases the risk of cardiovascular disease in adulthood. Arterial injury and stiffness parameters, including carotid intima media thickness (cIMT), pulse wave velocity (PWV) and distensibility (DIST), can be detected early in childhood. We studied the associations between cIMT, PWV and DIST with the lipoprotein profile assessed by proton nuclear magnetic resonance (1H NMR) and with influential variables such as blood pressure (BP) or body mass index (BMI) in children with FH.In this cross-sectional study, we included 201 children (96 with FH and 105 non-FH controls). Clinical history, physical examination and standard biochemical studies were performed. FH genetic testing was performed when clinically indicated. Carotid ultrasonography and an advanced lipoprotein profile by 1H NMR were performed. Multivariate and classification methods were used. There were no differences between cIMT, PWV and DIST between FH and non-FH children. FH children presented more total LDL and large, medium and small particles. Small LDL particles, BMI and systolic BP determined the presence of pathological IMT in the FH group. LDL size, high-density lipoproteins and very low-density lipoprotein particles together with blood pressure determined the presence of pathological arterial wall elasticity.Alterations in lipoprotein parameters assessed by are associated with early structural and functional arterial characteristics in children with FH. BMI and BP act as boosting factors. Cardiovascular prevention should start early in children with FH, encompassing all components of a healthy lifestyle.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
Thematic Areas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: daiana.ibarretxe@urv.cat luis.masana@urv.cat didac.llop@urv.cat celia.rodriguez@urv.cat jc.vallve@urv.cat albert.feliu@urv.cat didac.llop@urv.cat celia.rodriguez@urv.cat jc.vallve@urv.cat joaquin.escribano@urv.cat
Author identifier: 0000-0002-0789-4954 0000-0001-8160-3716 0000-0001-8160-3716 0000-0002-5041-459X
Record's date: 2024-08-10
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 33 (10): 2035-2043
APA: Llop, D; Feliu, A; Ibarretxe, D; Escribano, J; Plana, N; Borjabad-Rodriguez, C; Masana, L; Vallve, J C (2023). Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia. Nutrition Metabolism And Cardiovascular Diseases, 33(10), 2035-2043. DOI: 10.1016/j.numecd.2023.06.012
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV