Articles producció científica> Medicina i Cirurgia

Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia

  • Identification data

    Identifier: imarina:9330093
  • Authors:

    Llop, D
    Feliu, A
    Ibarretxe, D
    Escribano, J
    Plana, N
    Borjabad-Rodríguez, C
    Masana, L
    Vallvé, JC
    Nutrition Metabolism And Cardiovascular Diseases
    10.1016/j.numecd.2023.06.012
    Nutrition Metabolism And Cardiovascular Diseases. 33 (10): 2035-2043
  • Others:

    Author, as appears in the article.: Llop, D; Feliu, A; Ibarretxe, D; Escribano, J; Plana, N; Borjabad-Rodríguez, C; Masana, L; Vallvé, JC
    Department: Medicina i Cirurgia
    URV's Author/s: Escribano Subías, Joaquín / Feliu Rovira, Albert / Ibarretxe Gerediaga, Daiana / Llop Paredes, Dídac / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia / Vallvé Torrente, Joan Carles
    Keywords: Lipoprotein profile Intima-media thickness Familiar hypercholesterolemia Familiar hyper Children Arterial stiffness Arterial injury susceptibility subclinical atherosclerosis size pulse-wave velocity particle number low-density-lipoprotein lipoprotein pro file disease children cardiovascular risk arterial stiffness arterial injury
    Abstract: Children with familial hypercholesterolaemia (FH) have elevated low-density lipoprotein cholesterol (LDL-C) concentrations since birth, which increases the risk of cardiovascular disease in adulthood. Arterial injury and stiffness parameters, including carotid intima media thickness (cIMT), pulse wave velocity (PWV) and distensibility (DIST), can be detected early in childhood. We studied the associations between cIMT, PWV and DIST with the lipoprotein profile assessed by proton nuclear magnetic resonance (1H NMR) and with influential variables such as blood pressure (BP) or body mass index (BMI) in children with FH.In this cross-sectional study, we included 201 children (96 with FH and 105 non-FH controls). Clinical history, physical examination and standard biochemical studies were performed. FH genetic testing was performed when clinically indicated. Carotid ultrasonography and an advanced lipoprotein profile by 1H NMR were performed. Multivariate and classification methods were used. There were no differences between cIMT, PWV and DIST between FH and non-FH children. FH children presented more total LDL and large, medium and small particles. Small LDL particles, BMI and systolic BP determined the presence of pathological IMT in the FH group. LDL size, high-density lipoproteins and very low-density lipoprotein particles together with blood pressure determined the presence of pathological arterial wall elasticity.Alterations in lipoprotein parameters assessed by are associated with early structural and functional arterial characteristics in children with FH. BMI and BP act as boosting factors. Cardiovascular prevention should start early in children with FH, encompassing all components of a healthy lifestyle.Copyright © 2023 The Author(s). Published by Elsevier B.V. All rights reserved.
    Thematic Areas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: luis.masana@urv.cat didac.llop@urv.cat celia.rodriguez@urv.cat daiana.ibarretxe@urv.cat jc.vallve@urv.cat albert.feliu@urv.cat didac.llop@urv.cat celia.rodriguez@urv.cat jc.vallve@urv.cat joaquin.escribano@urv.cat
    Author identifier: 0000-0002-0789-4954 0000-0002-5041-459X
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nmcd-journal.com/article/S0939-4753(23)00245-4/fulltext#%20
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 33 (10): 2035-2043
    APA: Llop, D; Feliu, A; Ibarretxe, D; Escribano, J; Plana, N; Borjabad-Rodríguez, C; Masana, L; Vallvé, JC (2023). Lipoprotein profile assessed by 1H NMR, BMI and blood pressure are associated with vascular alterations in children with familial hypercholesterolaemia. Nutrition Metabolism And Cardiovascular Diseases, 33(10), 2035-2043. DOI: 10.1016/j.numecd.2023.06.012
    Article's DOI: 10.1016/j.numecd.2023.06.012
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Endocrinology & Metabolism,Endocrinology, Diabetes and Metabolism,Medicine (Miscellaneous),Nutrition & Dietetics,Nutrition and Dietetics
    Lipoprotein profile
    Intima-media thickness
    Familiar hypercholesterolemia
    Familiar hyper
    Children
    Arterial stiffness
    Arterial injury
    susceptibility
    subclinical atherosclerosis
    size
    pulse-wave velocity
    particle number
    low-density-lipoprotein
    lipoprotein pro file
    disease
    children
    cardiovascular risk
    arterial stiffness
    arterial injury
    Serviço social
    Saúde coletiva
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Enfermagem
    Endocrinology, diabetes and metabolism
    Endocrinology & metabolism
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
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