Author, as appears in the article.: Romero-Aroca, Pedro; Verges, Raquel; Pascual-Fontanilles, Jordi; Valls, Aida; Franch, Josep; Barrot, Joan; Mundet, Xavier; La Torre, Alex; Moreno, Antonio; Sagarra, Ramon; Basora, Josep; Garcia-Curto, Eugeni; Baget-Bernaldiz, Marc
Department: Enginyeria Informàtica i Matemàtiques
URV's Author/s: Baget Bernaldiz, Marc / Moreno Ribas, Antonio / Pascual Fontanilles, Jordi / Romero Aroca, Pedro / Valls Mateu, Aïda / Vergés Pujol, Raquel
Keywords: Tc/hdl-cholesterol ratio Statins Risk No-hdl-c/hdl-cholesterol ratio Lipids Fibrates Diabetic retinopathy 2 tc/hdl-cholesterol ratio statins progression prevention no-hdl-c/hdl-cholesterol ratio lipids fibrates disease diagnosis cholesterol
Abstract: (1) Background: Diabetic retinopathy (DR) remains the leading cause of low vision and blindness in young adults of working age. Although the most important risk factors—such as the duration of diabetes mellitus (DM) and glycemic control measured by HbA1c—are known, the effects of lipids are not as clear. The aim of the present study is to analyze the effects of lipids on the development of DR. (2) Methods: This is a retrospective study of a population of 175,645 DM2 patients, during the period 2010 to 2020, in which the effects of different lipid factors are studied. (3) Results: The variables that most influenced the development of DR in our study, based on significance and cumulative hazard (CH), were arterial hypertension (CH 1.217, p < 0.001), HbA1c levels (CH 1.162, p = 0.001), microalbuminuria (CH 1.012, p < 0.001), LDL-C cholesterol (CH 1.007, p = 0.012), TC/HDL-C index (CH 1.092, p < 0.001), No-HDL-C/HDL-C index (CH 1.065, p = 0.002), the use of statins (CH 1.001, p = 0.005), and body mass index (CH 1.007, p < 0.001). (4) Conclusions: LDL-cholesterol, TC/HDL-C, and No-HDL-C/HDL-C indices are related to the development of DR, and there is a protective effect of HDL-cholesterol and the use of fibrates.
Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: marc.baget@urv.cat raquel.vergesp@estudiants.urv.cat jordi.pascual@urv.cat jordi.pascual@urv.cat antonio.moreno@urv.cat pedro.romero@urv.cat aida.valls@urv.cat
Author identifier: 0000-0003-2693-0612 0000-0002-7528-5819 0000-0002-7528-5819 0000-0003-3945-2314 0000-0002-7061-8987 0000-0003-3616-7809
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2077-0383/12/20/6674
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Clinical Medicine. 12 (20): 6674-
APA: Romero-Aroca, Pedro; Verges, Raquel; Pascual-Fontanilles, Jordi; Valls, Aida; Franch, Josep; Barrot, Joan; Mundet, Xavier; La Torre, Alex; Moreno, Ant (2023). Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up. Journal Of Clinical Medicine, 12(20), 6674-. DOI: 10.3390/jcm12206674
Article's DOI: 10.3390/jcm12206674
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV