Author, as appears in the article.: Duran-Bertran, J; Rusu, EC; Barrientos-Riosalido, A; Bertran, L; Mahmoudian, R; Aguilar, C; Riesco, D; Martínez, S; Chicote, JU; Sabench, F; Richart, C; Auguet, T
Department: Medicina i Cirurgia
URV's Author/s: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Duran Bertran, Joan / Mahmoudianataabadi, Razieh / Martínez González, María Salomé / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima
Keywords: Platelets Obesity Nonalcoholic steatohepatitis Metabolic dysfunction-associated steatotic liver disease Mean platelet volume Fatty liver-disease volume severity platelets parameters obesity nonalcoholic steatohepatitis metabolic syndrome metabolic dysfunction-associated steatotic liver disease marker inflammation indexes fibrosis american association
Abstract: There is a lack of noninvasive diagnostic methods for nonalcoholic steatohepatitis (NASH), the severe condition of metabolic dysfunction-associated steatotic liver disease (MASLD). Platelet activation, evaluated through certain related parameters, is associated with liver disease and inflammation, but previous results are inconclusive.To investigate the potential utility of platelet-related indices as noninvasive diagnostic markers for the detection and prediction of MASLD, focusing on NASH.We found that mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) were increased in the severe and morbidly obese (SMO) group compared to the normal weight (NW) group. We found decreased levels of MPV in steatosis and NASH patients. MPV and PCT values were decreased in the presence of mild liver inflammation. Platelet count (PLA) and PCT values were lower in the presence of ballooning. We obtained an area under the ROC curve of 0.84 using MPV and three other variables to predict MASLD.Some platelet-related indices vary depending on liver condition. Here, we reported decreased MPV in MASLD presence. Moreover, we presented for the first time a predictive model using MPV, ALT levels and the presence of diabetes mellitus and metabolic syndrome to predict MASLD in obese women. Also, MPV is closely related to early liver inflammation in NASH, and PLA and PCT are related to hepatic ballooning. These indices could be widely used for the early detection of NASH since they are usually determined in routine laboratory tests.© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
Thematic Areas: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: andrea.barrientos@urv.cat davidgerardo.riesco@urv.cat joan.duran@urv.cat mariasalome.martinez@urv.cat cristobalmanuel.richart@urv.cat mariateresa.auguet@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat fatima.sabench@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat razieh.mahmoudianataabadi@estudiants.urv.cat
Author identifier: 0000-0001-6185-2889 0000-0003-0852-6739 0000-0003-0396-6428 0000-0002-4440-562X 0000-0002-4440-562X 0000-0002-9262-8756 0000-0001-9052-1368 0000-0001-9052-1368
Record's date: 2024-03-01
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1111/eci.14123
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: European Journal Of Clinical Investigation. 54 (3): e14123-e14123
APA: Duran-Bertran, J; Rusu, EC; Barrientos-Riosalido, A; Bertran, L; Mahmoudian, R; Aguilar, C; Riesco, D; Martínez, S; Chicote, JU; Sabench, F; Richart, (2024). Platelet-associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity. European Journal Of Clinical Investigation, 54(3), e14123-e14123. DOI: 10.1111/eci.14123
Article's DOI: 10.1111/eci.14123
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV