Articles producció científica> Medicina i Cirurgia

Platelet-associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity

  • Datos identificativos

    Identificador: imarina:9331791
    Autores:
    Duran-Bertran, JoanRusu, Elena CristinaBarrientos-Riosalido, AndreaBertran, LaiaMahmoudian, RaziehAguilar, CarmenRiesco, DavidMartinez, SalomeChicote, Javier UgarteSabench, FatimaRichart, CristobalAuguet, Teresa
    Resumen:
    There is a lack of noninvasive diagnostic methods for nonalcoholic steatohepatitis (NASH), the severe condition of metabolic dysfunction-associated steatotic liver disease (MASLD). Platelet activation, evaluated through certain related parameters, is associated with liver disease and inflammation, but previous results are inconclusive.To investigate the potential utility of platelet-related indices as noninvasive diagnostic markers for the detection and prediction of MASLD, focusing on NASH.We found that mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) were increased in the severe and morbidly obese (SMO) group compared to the normal weight (NW) group. We found decreased levels of MPV in steatosis and NASH patients. MPV and PCT values were decreased in the presence of mild liver inflammation. Platelet count (PLA) and PCT values were lower in the presence of ballooning. We obtained an area under the ROC curve of 0.84 using MPV and three other variables to predict MASLD.Some platelet-related indices vary depending on liver condition. Here, we reported decreased MPV in MASLD presence. Moreover, we presented for the first time a predictive model using MPV, ALT levels and the presence of diabetes mellitus and metabolic syndrome to predict MASLD in obese women. Also, MPV is closely related to early liver inflammation in NASH, and PLA and PCT are related to hepatic ballooning. These indices could be widely used for the early detection of NASH since they are usually determined in routine laboratory tests.© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
  • Otros:

    Autor según el artículo: Duran-Bertran, Joan; Rusu, Elena Cristina; Barrientos-Riosalido, Andrea; Bertran, Laia; Mahmoudian, Razieh; Aguilar, Carmen; Riesco, David; Martinez, Salome; Chicote, Javier Ugarte; Sabench, Fatima; Richart, Cristobal; Auguet, Teresa
    Departamento: Medicina i Cirurgia
    Autor/es de la URV: Aguilar Crespillo, Carmen Isabel / Auguet Quintillà, Maria Teresa / Barrientos Riosalido, Andrea / Bertran Ramos, Laia / Duran Bertran, Joan / Mahmoudianataabadi, Razieh / Martínez González, María Salomé / Richart Jurado, Cristobal Manuel / Riesco Acevedo, David Gerardo / Sabench Pereferrer, Fàtima
    Palabras clave: Polyesters Platelets Obesity, morbid Obesity Nonalcoholic steatohepatitis Non-alcoholic fatty liver disease Metabolic dysfunction-associated steatotic liver disease Metabolic diseases Mean platelet volume Inflammation Humans Female Fatty liver-disease Blood platelets Biomarkers volume severity platelets parameters obesity nonalcoholic steatohepatitis metabolic syndrome metabolic dysfunction-associated steatotic liver disease marker inflammation indexes fibrosis american association
    Resumen: There is a lack of noninvasive diagnostic methods for nonalcoholic steatohepatitis (NASH), the severe condition of metabolic dysfunction-associated steatotic liver disease (MASLD). Platelet activation, evaluated through certain related parameters, is associated with liver disease and inflammation, but previous results are inconclusive.To investigate the potential utility of platelet-related indices as noninvasive diagnostic markers for the detection and prediction of MASLD, focusing on NASH.We found that mean platelet volume (MPV), plateletcrit (PCT) and platelet distribution width (PDW) were increased in the severe and morbidly obese (SMO) group compared to the normal weight (NW) group. We found decreased levels of MPV in steatosis and NASH patients. MPV and PCT values were decreased in the presence of mild liver inflammation. Platelet count (PLA) and PCT values were lower in the presence of ballooning. We obtained an area under the ROC curve of 0.84 using MPV and three other variables to predict MASLD.Some platelet-related indices vary depending on liver condition. Here, we reported decreased MPV in MASLD presence. Moreover, we presented for the first time a predictive model using MPV, ALT levels and the presence of diabetes mellitus and metabolic syndrome to predict MASLD in obese women. Also, MPV is closely related to early liver inflammation in NASH, and PLA and PCT are related to hepatic ballooning. These indices could be widely used for the early detection of NASH since they are usually determined in routine laboratory tests.© 2023 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.
    Áreas temáticas: Saúde coletiva Odontología Nutrição Medicine, research & experimental Medicine, general & internal Medicine (miscellaneous) Medicina ii Medicina i Interdisciplinar General medicine Farmacia Educação física Clinical biochemistry Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biochemistry
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: cristobalmanuel.richart@urv.cat andrea.barrientos@urv.cat andrea.barrientos@urv.cat davidgerardo.riesco@urv.cat joan.duran@urv.cat mariasalome.martinez@urv.cat razieh.mahmoudianataabadi@estudiants.urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat fatima.sabench@urv.cat carmenisabel.aguilar@urv.cat carmenisabel.aguilar@urv.cat mariateresa.auguet@urv.cat
    Identificador del autor: 0000-0003-0852-6739 0000-0001-6185-2889 0000-0001-9052-1368 0000-0001-9052-1368 0000-0002-9262-8756 0000-0002-4440-562X 0000-0002-4440-562X 0000-0003-0396-6428
    Fecha de alta del registro: 2024-08-03
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/10.1111/eci.14123
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: European Journal Of Clinical Investigation. 54 (3): e14123-e14123
    Referencia de l'ítem segons les normes APA: Duran-Bertran, Joan; Rusu, Elena Cristina; Barrientos-Riosalido, Andrea; Bertran, Laia; Mahmoudian, Razieh; Aguilar, Carmen; Riesco, David; Martinez, (2024). Platelet-associated biomarkers in nonalcoholic steatohepatitis: Insights from a female cohort with obesity. European Journal Of Clinical Investigation, 54(3), e14123-e14123. DOI: 10.1111/eci.14123
    DOI del artículo: 10.1111/eci.14123
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2024
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry,Clinical Biochemistry,Medicine (Miscellaneous),Medicine, General & Internal,Medicine, Research & Experimental
    Polyesters
    Platelets
    Obesity, morbid
    Obesity
    Nonalcoholic steatohepatitis
    Non-alcoholic fatty liver disease
    Metabolic dysfunction-associated steatotic liver disease
    Metabolic diseases
    Mean platelet volume
    Inflammation
    Humans
    Female
    Fatty liver-disease
    Blood platelets
    Biomarkers
    volume
    severity
    platelets
    parameters
    obesity
    nonalcoholic steatohepatitis
    metabolic syndrome
    metabolic dysfunction-associated steatotic liver disease
    marker
    inflammation
    indexes
    fibrosis
    american association
    Saúde coletiva
    Odontología
    Nutrição
    Medicine, research & experimental
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Educação física
    Clinical biochemistry
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biochemistry
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