Articles producció científica> Bioquímica i Biotecnologia

Triglyceride content increases while cholesterol content decreases in HDL and LDL plus IDL fractions following normal meals: The Copenhagen General Population Study of 25,656 individuals

  • Identification data

    Identifier: imarina:9332637
    Authors:
    Johansen, MOMoreno-Vedia, JBalling, MSmith, GDNordestgaard, BG
    Abstract:
    Background and aims: During fat tolerance tests, plasma triglycerides increase while high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and intermediate-density lipoprotein (IDL) cholesterol decrease. However, it is unknown whether triglyceride content increases and cholesterol content decreases in HDL and LDL + IDL fractions following normal meals in the general population. Therefore, we tested the hypothesis that triglyceride content increases while cholesterol content decreases in HDL and LDL + IDL fractions following normal meals.Methods: In this cross-sectional study, we included 25,656 individuals aged 20-100 years, all without lipid lowering therapy at examination and selected for metabolomic profiling from the Copenhagen General Population Study. Triglyceride and cholesterol content of 14 lipoprotein fractions weas measured using nuclear magnetic resonance (NMR) spectroscopy. Time since last meal was recorded by the examiner immediately before blood sampling. Results: Following normal meals in age and sex-adjusted analyses and when compared with fasting levels, plasma triglycerides were higher for up to 5-6 h, and triglyceride content was higher for up to 6-7 h in HDL fractions, for up to 6-7 h in LDL + IDL fractions, and for up to 5-6 h in very-low-density lipoprotein (VLDL) fractions. Further, plasma cholesterol was lower for up to 2-3 h, and cholesterol content was lower for up to 0-1 h in HDL fractions and for up to 4-5 h in LDL + IDL fractions, while cholesterol content was higher for up to 4-5 h in VLDL fractions.Conclusions: Following normal meals, triglyceride content increases while cholesterol content decreases in HDL and LDL + IDL fractions.
  • Others:

    Author, as appears in the article.: Johansen, MO; Moreno-Vedia, J; Balling, M; Smith, GD; Nordestgaard, BG
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Moreno Vedia, Juan
    Keywords: Statement Risk Postprandial lipemia Postprandial Plasma Nonfasting triglycerides Myocardial-infarction Lipoprotein subfractions Lipoprotein cholesterol Lipids Lipid profile General population Cardiovascular-disease Cardiovascular disease Apolipoproteins
    Abstract: Background and aims: During fat tolerance tests, plasma triglycerides increase while high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and intermediate-density lipoprotein (IDL) cholesterol decrease. However, it is unknown whether triglyceride content increases and cholesterol content decreases in HDL and LDL + IDL fractions following normal meals in the general population. Therefore, we tested the hypothesis that triglyceride content increases while cholesterol content decreases in HDL and LDL + IDL fractions following normal meals.Methods: In this cross-sectional study, we included 25,656 individuals aged 20-100 years, all without lipid lowering therapy at examination and selected for metabolomic profiling from the Copenhagen General Population Study. Triglyceride and cholesterol content of 14 lipoprotein fractions weas measured using nuclear magnetic resonance (NMR) spectroscopy. Time since last meal was recorded by the examiner immediately before blood sampling. Results: Following normal meals in age and sex-adjusted analyses and when compared with fasting levels, plasma triglycerides were higher for up to 5-6 h, and triglyceride content was higher for up to 6-7 h in HDL fractions, for up to 6-7 h in LDL + IDL fractions, and for up to 5-6 h in very-low-density lipoprotein (VLDL) fractions. Further, plasma cholesterol was lower for up to 2-3 h, and cholesterol content was lower for up to 0-1 h in HDL fractions and for up to 4-5 h in LDL + IDL fractions, while cholesterol content was higher for up to 4-5 h in VLDL fractions.Conclusions: Following normal meals, triglyceride content increases while cholesterol content decreases in HDL and LDL + IDL fractions.
    Thematic Areas: Saúde coletiva Psicología Peripheral vascular disease Odontología Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Ciência da computação Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología Antropologia / arqueologia
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: juan.moreno@estudiants.urv.cat juan.moreno@estudiants.urv.cat
    Author identifier: 0000-0002-2673-3822 0000-0002-2673-3822
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.atherosclerosis-journal.com/article/S0021-9150(23)05237-1/fulltext#%20
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Atherosclerosis. 383
    APA: Johansen, MO; Moreno-Vedia, J; Balling, M; Smith, GD; Nordestgaard, BG (2023). Triglyceride content increases while cholesterol content decreases in HDL and LDL plus IDL fractions following normal meals: The Copenhagen General Population Study of 25,656 individuals. Atherosclerosis, 383(), -. DOI: 10.1016/j.atherosclerosis.2023.117316
    Article's DOI: 10.1016/j.atherosclerosis.2023.117316
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Cardiac & Cardiovascular Systems,Cardiology and Cardiovascular Medicine,Peripheral Vascular Disease
    Statement
    Risk
    Postprandial lipemia
    Postprandial
    Plasma
    Nonfasting triglycerides
    Myocardial-infarction
    Lipoprotein subfractions
    Lipoprotein cholesterol
    Lipids
    Lipid profile
    General population
    Cardiovascular-disease
    Cardiovascular disease
    Apolipoproteins
    Saúde coletiva
    Psicología
    Peripheral vascular disease
    Odontología
    Nutrição
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciência de alimentos
    Ciência da computação
    Cardiology and cardiovascular medicine
    Cardiac & cardiovascular systems
    Biotecnología
    Antropologia / arqueologia
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