Articles producció científica> Química Analítica i Química Orgànica

Wastewater-based epidemiology to assess pharmaceutical consumption. Spanish perspective

  • Identification data

    Identifier: imarina:9382498
    Authors:
    Fontanals, NuriaMarce, Rosa MariaMontes, RosaRodil, RosarioGonzalez-Marino, IriaValcarcel, YolandaRodriguez-Mozaz, SaraBorrull, FrancescQuintana, Jose BenitoPocurull, Eva
    Abstract:
    Wastewater-based epidemiology (WBE) is a well-established approach that can provide objective and real-time data on the consumption of substances such as pharmaceuticals. However, most of the studies reported so far compares consumption data obtained using WBE with those derived from prescription data from public health systems, which is often incomplete and might represent a source of uncertainty. This study aims to compare the measured pharmaceutical consumption back calculated with the WBE approach with consumption derived from dispensed pharmaceuticals in two regions of Spain, managed by two different Health Systems. To do so, a group of 17 pharmaceuticals, including the most representative ones of every therapeutic family, were monitored in influent wastewater (IWW) samples collected over a week campaign in spring 2022 at four different wastewater treatment plants (WWTPs) in Spain: two WWTPs in Madrid city (center of Spain) and two WWTPs in Catalonia (Northeast of Spain). Population-normalized daily loads (PNDL) revealed that the patterns of pharmaceutical occurrence in the different WWTPs are very similar, being acetaminophen, 4-acetamidoantipyrine and valsartan the pharmaceuticals with the highest PNDL values: 17162 +/- 1457 mg day(- 1) 1000 inh(-1 )for acetaminophen, 2365 +/- 696 and 2429 +/- 263 mg day(- 1) 1000 inh(-1) for 4-acetamidoantipyrine, 2006 +/- 541 and 2041 +/- 352 mg day(- 1 )1000 inh(-1) for valsartan. Pharmaceutical PNLDs were then transformed into measured pharmaceutical consumption (MC) and compared with dispensed consumption (DC) data obtained from the pharmacies in the catchment area where the WWTPs are located. A ratio MC/DC within 0.8 to 1.2 was obtained for 11 out of the 17 studied pharmaceuticals. Highlighting a match in all the cardiovasc
  • Others:

    Author, as appears in the article.: Fontanals, Nuria; Marce, Rosa Maria; Montes, Rosa; Rodil, Rosario; Gonzalez-Marino, Iria; Valcarcel, Yolanda; Rodriguez-Mozaz, Sara; Borrull, Francesc; Quintana, Jose Benito; Pocurull, Eva
    Department: Química Analítica i Química Orgànica
    URV's Author/s: Borrull Ballarín, Francesc / Fontanals Torroja, Núria / Marcé Recasens, Rosa Maria / Pocurull Aixala, Eva
    Keywords: Wastewater-based epidemiology Pharmaceuticals Influent wastewater Dispensed pharmaceutical data Consumption Consumptio
    Abstract: Wastewater-based epidemiology (WBE) is a well-established approach that can provide objective and real-time data on the consumption of substances such as pharmaceuticals. However, most of the studies reported so far compares consumption data obtained using WBE with those derived from prescription data from public health systems, which is often incomplete and might represent a source of uncertainty. This study aims to compare the measured pharmaceutical consumption back calculated with the WBE approach with consumption derived from dispensed pharmaceuticals in two regions of Spain, managed by two different Health Systems. To do so, a group of 17 pharmaceuticals, including the most representative ones of every therapeutic family, were monitored in influent wastewater (IWW) samples collected over a week campaign in spring 2022 at four different wastewater treatment plants (WWTPs) in Spain: two WWTPs in Madrid city (center of Spain) and two WWTPs in Catalonia (Northeast of Spain). Population-normalized daily loads (PNDL) revealed that the patterns of pharmaceutical occurrence in the different WWTPs are very similar, being acetaminophen, 4-acetamidoantipyrine and valsartan the pharmaceuticals with the highest PNDL values: 17162 +/- 1457 mg day(- 1) 1000 inh(-1 )for acetaminophen, 2365 +/- 696 and 2429 +/- 263 mg day(- 1) 1000 inh(-1) for 4-acetamidoantipyrine, 2006 +/- 541 and 2041 +/- 352 mg day(- 1 )1000 inh(-1) for valsartan. Pharmaceutical PNLDs were then transformed into measured pharmaceutical consumption (MC) and compared with dispensed consumption (DC) data obtained from the pharmacies in the catchment area where the WWTPs are located. A ratio MC/DC within 0.8 to 1.2 was obtained for 11 out of the 17 studied pharmaceuticals. Highlighting a match in all the cardiovascular system pharmaceuticals, with the exception of losartan (1.29-1.39 ratio) and valsartan (1.35-1.43) in all WWTPs. In summary, the degree of correlation between MC/DC is higher than those previously reported comparing with the prescribed pharmaceutical consumption.
    Thematic Areas: Zootecnia / recursos pesqueiros Waste management and disposal Saúde coletiva Química Pollution Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Historia Geografía Geociências Farmacia Environmental sciences Environmental engineering Environmental chemistry Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: francesc.borrull@urv.cat rosamaria.marce@urv.cat eva.pocurull@urv.cat nuria.fontanals@urv.cat
    Author identifier: 0000-0003-2718-9336 0000-0002-5667-2899 0000-0001-5123-995X 0000-0002-7534-1964
    Record's date: 2024-10-05
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0048969724062648?via%3Dihub
    Papper original source: Science Of The Total Environment. 953 176108-
    APA: Fontanals, Nuria; Marce, Rosa Maria; Montes, Rosa; Rodil, Rosario; Gonzalez-Marino, Iria; Valcarcel, Yolanda; Rodriguez-Mozaz, Sara; Borrull, Francesc (2024). Wastewater-based epidemiology to assess pharmaceutical consumption. Spanish perspective. Science Of The Total Environment, 953(), 176108-. DOI: 10.1016/j.scitotenv.2024.176108
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.scitotenv.2024.176108
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Environmental Chemistry,Environmental Engineering,Environmental Sciences,Pollution,Waste Management and Disposal
    Wastewater-based epidemiology
    Pharmaceuticals
    Influent wastewater
    Dispensed pharmaceutical data
    Consumption
    Consumptio
    Zootecnia / recursos pesqueiros
    Waste management and disposal
    Saúde coletiva
    Química
    Pollution
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Historia
    Geografía
    Geociências
    Farmacia
    Environmental sciences
    Environmental engineering
    Environmental chemistry
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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