Author, as appears in the article.: Gabaldon-Figueira, Juan Carlos; Ros-Lucas, Albert; Martinez-Peinado, Nieves; Blackburn, Gavin; Losada-Galvan, Irene; Posada, Elizabeth; Ballart, Cristina; Escabia, Elisa; Capellades, Jordi; Yanes, Oscar; Pinazo, Maria-Jesus; Gascon, Joaquim; Alonso-Padilla, Julio
Department: Enginyeria Electrònica, Elèctrica i Automàtica
URV's Author/s: Yanes Torrado, Óscar
Keywords: <italic>trypanosoma cruzi</italic> Adult Biomarkers Chagas disease Chromatography, liquid Chronic disease Disease progression Female Humans Hydroxydecanoic acid Lipidomics Lipids Male Mass spectrometry Metabolis Metabolomics Middle aged Phosphatidylethanolamine Sphingolipid Sphingolipids Treatment outcome Treatment response Trypanosoma cruzi
Abstract: BackgroundChagas disease, caused by the parasite Trypanosoma cruzi, is a zoonosis that affects more than seven million people. Current limitations on the diagnosis of the disease hinder the prognosis of patients and the evaluation of treatment efficacy, slowing the development of new therapeutic options. The infection is known to disrupt several host metabolic pathways, providing an opportunity for the identification of biomarkers.MethodsThe metabolomic and lipidomic profiles of a cohort of symptomatic and asymptomatic patients with T. cruzi infection and a group of uninfected controls were analysed using liquid chromatography/mass spectrometry. Differences among all groups and changes before and after receiving anti-parasitic treatment across those with T. cruzi infection were explored.ResultsThree lipids were found to differentiate between symptomatic and asymptomatic participants: 10-hydroxydecanoic acid and phosphatidylethanolamines PE(18:0/20:4) and PE(18:1/20:4). Additionally, sphinganine, 4-hydroxysphinganine, hexadecasphinganine, and other sphingolipids showed post-treatment abundance similar to that in non-infected controls.ConclusionsThese molecules hold promise as potentially useful biomarkers for monitoring disease progression and treatment response in patients with chronic T. cruzi infection.
Thematic Areas: Biodiversidade Biotecnología Ciência da computação Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Enfermagem Engenharias i Engenharias ii Engenharias iii Ensino Farmacia Geografía Infectious diseases Interdisciplinar Materiais Medicina i Medicina ii Medicina veterinaria Parasitology Química Saúde coletiva Tropical medicine Veterinary (all) Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: oscar.yanes@urv.cat
Author identifier: 0000-0003-3695-7157
Record's date: 2024-11-23
Papper version: info:eu-repo/semantics/publishedVersion
Papper original source: Parasites & Vectors. 17 (1): 459-
APA: Gabaldon-Figueira, Juan Carlos; Ros-Lucas, Albert; Martinez-Peinado, Nieves; Blackburn, Gavin; Losada-Galvan, Irene; Posada, Elizabeth; Ballart, Crist (2024). Changes in lipid abundance are associated with disease progression and treatment response in chronic Trypanosoma cruzi infection. Parasites & Vectors, 17(1), 459-. DOI: 10.1186/s13071-024-06548-3
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV