Autor según el artículo: Gabaldon-Figueira, Juan Carlos; Ros-Lucas, Albert; Martinez-Peinado, Nieves; Blackburn, Gavin; Losada-Galvan, Irene; Posada, Elizabeth; Ballart, Cristina; Escabia, Elisa; Capellades, Jordi; Yanes, Oscar; Pinazo, Maria-Jesus; Gascon, Joaquim; Alonso-Padilla, Julio
Departamento: Enginyeria Electrònica, Elèctrica i Automàtica
Autor/es de la URV: Yanes Torrado, Óscar
Palabras clave: <italic>trypanosoma cruzi</italic> Adult Biomarkers Chagas disease Chromatography, liquid Chronic disease Disease progression Female Humans Hydroxydecanoic acid Lipidomics Lipids Male Mass spectrometry Metabolis Metabolomics Middle aged Phosphatidylethanolamine Sphingolipid Sphingolipids Treatment outcome Treatment response Trypanosoma cruzi
Resumen: BackgroundChagas disease, caused by the parasite Trypanosoma cruzi, is a zoonosis that affects more than seven million people. Current limitations on the diagnosis of the disease hinder the prognosis of patients and the evaluation of treatment efficacy, slowing the development of new therapeutic options. The infection is known to disrupt several host metabolic pathways, providing an opportunity for the identification of biomarkers.MethodsThe metabolomic and lipidomic profiles of a cohort of symptomatic and asymptomatic patients with T. cruzi infection and a group of uninfected controls were analysed using liquid chromatography/mass spectrometry. Differences among all groups and changes before and after receiving anti-parasitic treatment across those with T. cruzi infection were explored.ResultsThree lipids were found to differentiate between symptomatic and asymptomatic participants: 10-hydroxydecanoic acid and phosphatidylethanolamines PE(18:0/20:4) and PE(18:1/20:4). Additionally, sphinganine, 4-hydroxysphinganine, hexadecasphinganine, and other sphingolipids showed post-treatment abundance similar to that in non-infected controls.ConclusionsThese molecules hold promise as potentially useful biomarkers for monitoring disease progression and treatment response in patients with chronic T. cruzi infection.
Áreas temáticas: Biodiversidade Biotecnología Ciência da computação Ciências agrárias i Ciências ambientais Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Enfermagem Engenharias i Engenharias ii Engenharias iii Ensino Farmacia Geografía Infectious diseases Interdisciplinar Materiais Medicina i Medicina ii Medicina veterinaria Parasitology Química Saúde coletiva Tropical medicine Veterinary (all) Zootecnia / recursos pesqueiros
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: oscar.yanes@urv.cat
Identificador del autor: 0000-0003-3695-7157
Fecha de alta del registro: 2024-11-23
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Referencia al articulo segun fuente origial: Parasites & Vectors. 17 (1): 459-
Referencia de l'ítem segons les normes APA: Gabaldon-Figueira, Juan Carlos; Ros-Lucas, Albert; Martinez-Peinado, Nieves; Blackburn, Gavin; Losada-Galvan, Irene; Posada, Elizabeth; Ballart, Crist (2024). Changes in lipid abundance are associated with disease progression and treatment response in chronic Trypanosoma cruzi infection. Parasites & Vectors, 17(1), 459-. DOI: 10.1186/s13071-024-06548-3
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2024
Tipo de publicación: Journal Publications
Repositori URV