Autor según el artículo: Javier Luque; Marta Sanchis; Mariana Castanheira; Adela Martin-Vicente; Deanna A. Sutton; Annette W. Fothergill; Nathan P. Wiederhold; Josep Guarro

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: CAPILLA LUQUE, JAVIER; Marta Sanchis; Mariana Castanheira; Adela Martin-Vicente; Deanna A. Sutton; Annette W. Fothergill; Nathan P. Wiederhold; GUARRO ARTIGAS, JOSEP

Palabras clave: voriconazole fungal infection Candida glabrata

Resumen: In this study, 27 clinical isolates of Candida glabrata with voriconazole (VRC) minimum inhibitory concentrations (MICs) ranging from ¿0.03 ¿g/mL to 8 ¿g/mL were tested to determine whether in vitro data are predictive of in vivo efficacy. The efficacy of VRC administered at 40 mg/kg was assayed in a neutropenic murine model of disseminated infection by C. glabrata. The reduction in fungal tissue burden in the kidneys was used as a marker of treatment efficacy. VRC reduced the fungal tissue burden in mice infected with strains that had MICs below the epidemiological cut-off value (ECV) of 0.25 ¿g/mL. Variable efficacy of VRC was obtained when the MIC equalled the ECV, and VRC was ineffective when the MIC exceeded the ECV. These results suggest that the use of in vitro data could be useful to predict the outcome for infections by this fungus.

Grupo de investigación: Unitat de Micologia i Microbiologia Ambiental

Áreas temáticas: Health sciences Ciencias de la salud Ciències de la salut

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 0924-8579

Identificador del autor: 0000-0002-0765-6403; 0000-0002-7839-7568

Fecha de alta del registro: 2016-05-24

Página final: 288

Volumen de revista: 47

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0924857916000431

DOI del artículo: 10.1016/j.ijantimicag.2015.12.020

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Página inicial: 286

Tipo de publicación: Article Artículo Article