Autor según el artículo: Salas-Salvadó J; Smith CE; Coltell O; Sorlí JV; Estruch R; Martínez-González MÁ; Fitó M; Arós F; Dashti HS; Lai CQ; Miró L; Serra-Majem L; Gómez-Gracia E; Fiol M; Ros E; Aslibekyan S; Hidalgo B; Neuhouser ML; Di C; Tucker KL; Arnett DK; Ordovás JM; Corella D

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: SALAS SALVADÓ, JORGE; Smith CE; Coltell O; Sorlí JV; Estruch R; Martínez-González MÁ; Fitó M; Arós F; Dashti HS; Lai CQ; Miró L; Serra-Majem L; Gómez-Gracia E; Fiol M; Ros E; Aslibekyan S; Hidalgo B; Neuhouser ML; Di C; Tucker KL; Arnett DK; Ordovás JM; Corella D

Palabras clave: MCM6-rs3754686 cardiovascular biomarkers Mortality

Resumen: Controversy persists on the association between dairy products, especially milk, and cardiovascular diseases (CVD). Genetic proxies may improve dairy intake estimations, and clarify diet-disease relationships through Mendelian randomization. We meta-analytically (n ≤ 20,089) evaluated associations between a lactase persistence (LP) SNP, the minichromosome maintenance complex component 6 (MCM6)-rs3754686C>T (nonpersistence>persistence), dairy intake, and CVD biomarkers in American (Hispanics, African-American and Whites) and Mediterranean populations. Moreover, we analyzed longitudinal associations with milk, CVD and mortality in PREDIMED), a randomized Mediterranean diet (MedDiet) intervention trial (n = 7185). The MCM6-rs3754686/MCM6-rs309180 (as proxy), LP-allele (T) was strongly associated with higher milk intake, but inconsistently associated with glucose and lipids, and not associated with CVD or total mortality in the whole population. Heterogeneity analyses suggested some sex-specific associations. The T-allele was associated with higher CVD and mortality risk in women but not in men (P-sex interaction:0.005 and 0.032, respectively), mainly in the MedDiet group. However, milk intake was not associated with CVD biomarkers, CVD or mortality either generally or in sub-groups. Although MCM6-rs3754686 is a good milk intake proxy in these populations, attributing its associations with CVD and mortality in Mediterranean women to milk is unwarranted, as other factors limiting the assumption of causality in Mendelian randomization may exist.

Grupo de investigación: Alimentació, Nutrició, Creixement i Salut Mental

Áreas temáticas: Bioquímica i biotecnologia Bioquímica y tecnología Biochemistry and technology

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 2045-2322

Fecha de alta del registro: 2016-09-16

Página final: 33188

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.nature.com/articles/srep33188

DOI del artículo: https://doi.org/10.1038/srep33188

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2016

Página inicial: 33188

Tipo de publicación: Article Artículo Article