Autor según el artículo: Jakszyn P, Fonseca-Nunes A, Lujan-Barroso L, Aranda N, Tous M, Arija V, Cross A, Bueno-de-Mesquita HBA, Weiderpass E, Kühn T, Kaaks R, Sjöberg K, Ohlsson B, Tumino R, Palli D, Ricceri F, Fasanelli F, Krogh V, Mattiello A, Jenab M, Gunter M, Perez-Cornago A, Khaw KT, Tjønneland A, Olsen A, Overvad K, Trichopoulou A, Peppa E, Vasilopoulou E, Boeing H, Sánchez-Cantalejo E, Huerta JM, Dorronsoro M, Barricarte A, Quirós JM, Peeters PH, Agudo A

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Aranda Pons, Núria / Arija Val, Maria Victoria / TOUS MÁRQUEZ, MÒNICA

Palabras clave: Iron homeostasis Hepcidin Gastric cancer Cohort study

Resumen: Hepcidin is the main regulator of iron homeostasis and dysregulation of proteins involved in iron metabolism has been associated with tumorogenesis. However, to date, no epidemiological study has researched the association between hepcidin levels and gastric cancer risk. To further investigate the relationship between hepcidin levels and gastric cancer risk, we conducted a nested case-control study (EURGAST) within the multicentric European Prospective Investigation into Cancer and Nutrition study. The study included 456 primary incident gastric adenocarcinoma cases and 900 matched controls that occurred during an average of 11 years of follow-up. We measured serum levels of hepcidin-25, iron, ferritin, transferrin and C-reactive protein. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of gastric cancer by hepcidin levels were estimated from multivariable conditional logistic regression models. Mediation effect of the ferritin levels on the hepcidin-gastric cancer pathway was also evaluated. After adjusting for relevant confounders, we observed a statistically significant inverse association between gastric cancer and hepcidin levels (OR 5 ng/l?=?0.96, 95% CI?=?0.93-0.99). No differences were found by tumor localization or histological type. In mediation analysis, we found that the direct effect of hepcidin only represents a nonsignificant 38% (95% CI: -69%, 91%). In summary, these data suggest that the inverse association of hepcidin levels and gastric cancer risk was mostly accounted by ferritin levels. Further investigation including repeated measures of hepcidin is needed to clarify their role in gastric carcinogenesis.© 2017 UICC.

Áreas temáticas: Saúde coletiva Química Oncology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Cancer research Biotecnología Biodiversidade

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00207136

Direcció de correo del autor: nuria.aranda@urv.cat victoria.arija@urv.cat

Identificador del autor: 0000-0001-9708-747X 0000-0002-1758-0975

Fecha de alta del registro: 2023-02-18

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.30797

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: International Journal Of Cancer. 141 (5): 945-951

Referencia de l'ítem segons les normes APA: Jakszyn P, Fonseca-Nunes A, Lujan-Barroso L, Aranda N, Tous M, Arija V, Cross A, Bueno-de-Mesquita HBA, Weiderpass E, Kühn T, Kaaks R, Sjöberg K, Ohls (2017). Hepcidin levels and gastric cancer risk in the EPIC-EurGast study.. International Journal Of Cancer, 141(5), 945-951. DOI: 10.1002/ijc.30797

DOI del artículo: 10.1002/ijc.30797

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications