Autor según el artículo: Esplugas, Roser; Isabel Llovet, Maria; Belles, Montserrat; Serra, Noemi; Caries Vallve, Joan; Luis Domingo, Jose; Linares, Victoria
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Bellés Mateu, Montserrat / Domingo Roig, José Luis / Esplugas Borràs, Roser / Linares Vidal, M. Victoria / Serra Encinas, Noemi / Vallvé Torrente, Joan Carles
Palabras clave: Good health and well-being
Resumen: 137-Cesium (137Cs) is one of the most important distributed radionuclides after a nuclear accident. Humans are usually co-exposed to various environmental toxicants, being Bisphenol-A (BPA) one of them. Exposure to IR and BPA in early life is of major concern, due to the higher vulnerability of developing organs. We evaluate the renal and hepatic effects of low doses of ionizing radiation (IR) and BPA. Sixty male mice (C57BL/6J) were randomly assigned to six experimental groups (n=10) and received a single subcutaneous dose of 0.9% saline solution, 137Cs and/or BPA on postnatal day 10: control, BPA (25 ?g/kgbw), Cs4000 (4000 Bq 137Cs/kgbw), Cs8000 (8000 Bq 137Cs/kgbw), BPA/Cs4000 and BPA/Cs8000. At the age of two months, urines (24h) and blood samples were collected from animals of each group to determine biochemical parameters. Finally, kidneys and liver were removed to quantify DNA damage (8-OHdG), as well as to determine CYP1A2 mRNA expression. Data suggest that both BPA and 137Cs induced renal and liver damage evidenced by oxidative stress. However, when there is a co-exposure, it seems that there are compensatory mechanisms that may reverse the damage induced by each toxic itself. Notwithstanding, more studies are necessary to better understand the synergistic mechanisms behind.Copyright © 2018 Elsevier Ltd. All rights reserved.
Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Direcció de correo del autor: roser.esplugas@urv.cat jc.vallve@urv.cat noemi.serra@urv.cat joseluis.domingo@urv.cat mvictoria.linares@urv.cat jc.vallve@urv.cat montserrat.belles@urv.cat
Identificador del autor: 0000-0002-5927-1644 0000-0002-2277-351X 0000-0001-6647-9470 0000-0003-4170-4197 0000-0002-9282-2989
Fecha de alta del registro: 2024-11-16
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
Enlace a la fuente original: https://www.sciencedirect.com/science/article/abs/pii/S0278691518301200?via%3Dihub
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 114 270-277
Referencia de l'ítem segons les normes APA: Esplugas, Roser; Isabel Llovet, Maria; Belles, Montserrat; Serra, Noemi; Caries Vallve, Joan; Luis Domingo, Jose; Linares, Victoria (2018). Renal and hepatic effects following neonatal exposure to low doses of Bisphenol-A and137Cs. Food And Chemical Toxicology, 114(), 270-277. DOI: 10.1016/j.fct.2018.02.046
DOI del artículo: 10.1016/j.fct.2018.02.046
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications
Repositori URV