Autor según el artículo: Gasull M; Castell C; Pallarès N; Miret C; Pumarega J; Téllez-Plaza M; López T; Salas-Salvadó J; Lee DH; Goday A; Porta M

Departamento: Bioquímica i Biotecnologia

Autor/es de la URV: Salas Salvadó, Jorge

Palabras clave: Persistent organic pollutants Metabolically healthy obese Metabolic syndrome Metabolic phenotype Human biomonitoring Health survey Environmental pollutants/toxicity Environmental exposure/adverse effects

Resumen: © The Author(s) 2017. Factors underlying metabolic phenotypes, such as the metabolically healthy but obese phenotype, remain unclear. Differences in metabolic phenotypes - particularly, among individuals with a similar body mass index - could be related to concentrations of persistent organic pollutants (POPs). To our knowledge, no studies have analyzed POPs and metabolic phenotypes in normal-weight persons. We investigated the relationships between serum concentrations of POPs and metabolic phenotypes in 860 normal-weight, overweight, and obese participants in the 2002 Catalan Health Interview Survey (Spain). POP concentrations were significantly higher in metabolically unhealthy than in metabolically healthy individuals. In models adjusting for body mass index and other confounders, hexachlorobenzene, ?-hexachlorocyclohexane, and polychlorinated biphenyls were associated with the unhealthy metabolic phenotype and metabolic syndrome. Among normal-weight individuals, the adjusted prevalence ratio of having an unhealthy phenotype for the upper category of the sum of orders of the 6 mentioned POPs (all individually associated with metabolic phenotypes) was 4.1 (95% confidence interval: 1.7, 10.0). Among overweight and obese individuals, the corresponding prevalence ratio for the sum of polychlorinated biphenyls was 1.4 (95% confidence interval: 1.0, 1.8). Our results supported the hypothesis that POP concentrations are associated with unhealthy metabolic phenotypes, not only in obese and overweight individuals but also (and probably more strongly) in normal-weight individuals.

Áreas temáticas: Saúde coletiva Public, environmental & occupational health Planejamento urbano e regional / demografia Nutrição Medicine (all) Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Epidemiology Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 00029262

Direcció de correo del autor: jordi.salas@urv.cat

Identificador del autor: 0000-0003-2700-7459

Fecha de alta del registro: 2023-07-31

Versión del articulo depositado: info:eu-repo/semantics/submittedVersion

Enlace a la fuente original: https://academic.oup.com/aje/article/187/3/494/3903147

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: American Journal Of Epidemiology. 187 (3): 494-506

Referencia de l'ítem segons les normes APA: Gasull M; Castell C; Pallarès N; Miret C; Pumarega J; Téllez-Plaza M; López T; Salas-Salvadó J; Lee DH; Goday A; Porta M (2018). Blood Concentrations of Persistent Organic Pollutants and Unhealthy Metabolic Phenotypes in Normal-Weight, Overweight, and Obese Individuals. American Journal Of Epidemiology, 187(3), 494-506. DOI: 10.1093/aje/kwx267

DOI del artículo: 10.1093/aje/kwx267

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications