Autor según el artículo: Tomas, Josep; Garcia, Neus; Lanuza, Maria A; Santafe, Manel M; Tomas, Marta; Nadal, Laura; Hurtado, Erica; Simo-Olle, Anna; Cilleros-Mane, Vctor; Just-Borras, Laia
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Hurtado Caballero, Erica / Just Borràs, Laia / Lanuza Escolano, María Angel / NADAL MAGRIÑÀ, LAURA / Santafé Martínez, Manuel / SIMÓ OLLÉ, ANNA / Tomás Ferré, José Maria / Tomas Marginet, Marta
Palabras clave: Trkb Postnatal synapse elimination Neurotrophins Muscarinic acetylcholine receptors Motor end-plate Axonal competition Adenosine receptors Acetylcholine release trkb neurotrophins muscarinic acetylcholine receptors motor end-plate axonal competition adenosine receptors acetylcholine release
Resumen: © 2018 Tomàs, Garcia, Lanuza, Santafé, Tomàs, Nadal, Hurtado, Simó-Ollé, Cilleros-Mañé and Just-Borràs. In the last few years, we have studied the presence and involvement in synaptogenesis and mature transmitter release of the adenosine autoreceptors (AR) in the mammalian neuromuscular junction (NMJ). Here, we review and bring together the previously published data to emphasize the relevance of these receptors for developmental axonal competition, synaptic loss and mature NMJ functional modulation. However, in addition to AR, activity-dependent mediators originating from any of the three cells that make the synapse (nerve, muscle, and glial cells) cross the extracellular cleft to generate signals in target metabotropic receptors. Thus, the integrated interpretation of the complementary function of all these receptors is needed. We previously studied, in the NMJ, the links of AR with mAChR and the neurotrophin receptor TrkB in the control of synapse elimination and transmitter release. We conclude that AR cooperate with these receptors through synergistic and antagonistic effects in the developmental synapse elimination process. In the adult NMJ, this cooperation is manifested so as that the functional integrity of a given receptor group depends on the other receptors operating normally (i.e., the functional integrity of mAChR depends on AR operating normally). These observations underlie the relevance of AR in the NMJ function.
Áreas temáticas: Psicología Pharmacology (medical) Pharmacology & pharmacy Pharmacology Odontología Medicina veterinaria Medicina ii Medicina i Interdisciplinar Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16639812
Direcció de correo del autor: laia.just@urv.cat marta.tomas@urv.cat erica.hurtado@urv.cat victor.cilleros@alumni.urv.cat josepmaria.tomas@urv.cat laia.just@urv.cat mariaangel.lanuza@urv.cat manuel.santafe@urv.cat
Identificador del autor: 0000-0003-0473-3730 0000-0002-4151-1697 0000-0001-5690-9932 0000-0002-0406-0006 0000-0003-0473-3730 0000-0003-4795-4103 0000-0002-5462-5108
Fecha de alta del registro: 2024-10-12
Volumen de revista: 9
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fphar.2018.00397/full
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Frontiers In Pharmacology. 9 (397): 397-
Referencia de l'ítem segons les normes APA: Tomas, Josep; Garcia, Neus; Lanuza, Maria A; Santafe, Manel M; Tomas, Marta; Nadal, Laura; Hurtado, Erica; Simo-Olle, Anna; Cilleros-Mane, Vctor; Just (2018). Adenosine receptors in developing and adult mouse neuromuscular junctions and functional links with other metabotropic receptor pathways. Frontiers In Pharmacology, 9(397), 397-. DOI: 10.3389/fphar.2018.00397
DOI del artículo: 10.3389/fphar.2018.00397
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Página inicial: 397
Tipo de publicación: Journal Publications