Autor según el artículo: Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M
Departamento: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques Psicologia
Autor/es de la URV: BASAURE GARCÍA, PÍA ISABEL / Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa / Domingo Roig, José Luis / Guardia Escoté, Laia
Palabras clave: Synaptic transmission Spatial memory Sex factors Receptors, nicotinic Receptors, muscarinic Pesticide Mice, transgenic Mice, inbred c57bl Maze learning Male Learning and memory Learning Insecticides Hippocampus Genotype Gene expression profiling Frontal lobe Female Cholinergic system Cholinergic synapses Chlorpyrifos Brain development Apolipoprotein e4 Apoe Animals learning and memory cholinergic system chlorpyrifos brain development apoe
Resumen: © 2018 Elsevier Ltd Organophosphorus pesticides – and in particular chlorpyrifos (CPF) – are extensively used worldwide. They mainly exert their toxicity by targeting the cholinergic system. Several studies suggested that the gene coding for apolipoprotein E (apoE), which is a risk factor for several diseases, can also confer different vulnerability to toxic insults. This study was aimed at assessing the long-term effects of postnatal exposure to CPF on learning and memory as well as the expression levels of several genes involved in cholinergic neurotransmission in mice. Both male and female apoE4-TR and C57BL/6 mice were exposed to either 0 or 1 mg/kg/day of CPF by oral gavage using a micropipette on postnatal days 10–15. At 9 months, they were tested in a Morris Water Maze (MWM) and the gene expression in the frontal cortex and hippocampus was evaluated. Our results show that, in males, CPF had an effect on the spatial retention, while in females, it altered the expression levels of nicotinic receptors. Furthermore, apoE4-TR mice performed the worst during the MWM retention and presented low expression levels in a considerable number of cholinergic genes. Taken together, the current results reveal long-term effects in mice nine months after postnatal exposure to CPF, which are modulated by sex and apoE4 genotype.
Áreas temáticas: Toxicology Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 02786915
Direcció de correo del autor: maria.cabre@urv.cat joseluis.domingo@urv.cat jordi.blanco@urv.cat mariateresa.colomina@urv.cat
Identificador del autor: 0000-0003-4124-8603 0000-0001-6647-9470 0000-0001-8016-0984 0000-0002-5619-4874
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Food And Chemical Toxicology. 122 1-10
Referencia de l'ítem segons les normes APA: Guardia-Escote L; Basaure P; Blanco J; Cabré M; Pérez-Fernández C; Sánchez-Santed F; Domingo J; Colomina M (2018). Postnatal exposure to chlorpyrifos produces long-term effects on spatial memory and the cholinergic system in mice in a sex- and APOE genotype-dependent manner. Food And Chemical Toxicology, 122(), 1-10. DOI: 10.1016/j.fct.2018.09.069
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2018
Tipo de publicación: Journal Publications
Repositori URV