Autor según el artículo: Casciati A; Dobos K; Antonelli F; Benedek A; Kempf SJ; Bellés M; Balogh A; Tanori M; Heredia L; Atkinson MJ; von Toerne C; Azimzadeh O; Saran A; Sáfrány G; Benotmane MA; Linares-Vidal MV; Tapio S; Lumniczky K; Pazzaglia S
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Bellés Mateu, Montserrat / Heredia Santaella, Luis / Linares Vidal, M. Victoria
Palabras clave: cognitive effects hippocampal neurogenesis mitochondria proteomics Cognitive effects Hippocampal neurogenesis Mitochondria Proteomics Radiation
Resumen: Therapeutic irradiation of pediatric and adult patients can profoundly affect adult neurogenesis, and cognitive impairment manifests as a deficit in hippocampal-dependent functions. Age plays a major role in susceptibility to radiation, and younger children are at higher risk of cognitive decay when compared to adults. Cranial irradiation affects hippocampal neurogenesis by induction of DNA damage in neural progenitors, through the disruption of the neurogenic microenvironment, and defective integration of newborn neurons into the neuronal network. Our goal here was to assess cellular and molecular alterations induced by cranial X-ray exposure to low/moderate doses (0.1 and 2 Gy) in the hippocampus of mice irradiated at the postnatal ages of day 10 or week 10, as well as the dependency of these phenomena on age at irradiation. To this aim, changes in the cellular composition of the dentate gyrus, mitochondrial functionality, proteomic profile in the hippocampus, as well as cognitive performance were evaluated by a multidisciplinary approach. Our results suggest the induction of specific alterations in hippocampal neurogenesis, microvascular density and mitochondrial functions, depending on age at irradiation. A better understanding of how irradiation impairs hippocampal neurogenesis at low and moderate doses is crucial to minimize adverse effects of therapeutic irradiation, contributing also to radiation safety regulations.
Áreas temáticas: Administração pública e de empresas, ciências contábeis e turismo Astronomia / física Biodiversidade Biotecnología Cell biology Ciência da computação Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Engenharias ii Farmacia Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Odontología Oncology Química Zootecnia / recursos pesqueiros
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: mvictoria.linares@urv.cat montserrat.belles@urv.cat luis.heredia@urv.cat
ISSN: 19492553
Identificador del autor: 0000-0003-4170-4197 0000-0002-9282-2989 0000-0001-9330-9418
Fecha de alta del registro: 2023-03-05
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.oncotarget.com/article/8575/text/
Referencia al articulo segun fuente origial: Oncotarget. 7 (19): 28040-58
Referencia de l'ítem segons les normes APA: Casciati A; Dobos K; Antonelli F; Benedek A; Kempf SJ; Bellés M; Balogh A; Tanori M; Heredia L; Atkinson MJ; von Toerne C; Azimzadeh O; Saran A; Sáfrá (2016). Age-related effects of X-ray irradiation on mouse hippocampus. Oncotarget, 7(19), 28040-58. DOI: 10.18632/oncotarget.8575
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.18632/oncotarget.8575
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2016
Tipo de publicación: Journal Publications