Autor según el artículo: Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M.

Departamento: Enginyeria Química Bioquímica i Biotecnologia

Autor/es de la URV: Ardèvol Grau, Anna / Blay Olivé, Maria Teresa / GINÉS MIR, IRIS / Pinent Armengol, Montserrat / Terra Barbadora, Ximena

Palabras clave: Proanthocyanidins Oxidative stress Obesity Intestine Inflammation Gut microbiota Gut Cafeteria diet obesity inflammation gut cafeteria diet zo zonula occludens tj tight junctions rv reverse ros reactive oxygen species pc principal components ocln occludin mpo myeloperoxidase lepr leptin receptor inos isoform of nitric oxide synthase homa-ir homeostasis model assessment of insulin resistance go genetic obesity gi gastrointestinal fw forward caf diet cafeteria diet

Resumen: The gastrointestinal alterations associated with the consumption of an obesogenic diet, such as inflammation, permeability impairment and oxidative stress, have been poorly explored in both diet-induced obesity (DIO) and genetic obesity. The aim of the present study was to examine the impact of an obesogenic diet on the gut health status of DIO rats in comparison with the Zucker (fa/fa) rat leptin receptor-deficient model of genetic obesity over time. For this purpose, female Wistar rats (n 48) were administered a standard or a cafeteria diet (CAF diet) for 12, 14·5 or 17 weeks and were compared with fa/fa Zucker rats fed a standard diet for 10 weeks. Morphometric variables, plasma biochemical parameters, myeloperoxidase (MPO) activity and reactive oxygen species (ROS) levels in the ileum were assessed, as well as the expressions of proinflammatory genes (TNF-α and inducible nitric oxide synthase (iNOS)) and intestinal permeability genes (zonula occludens-1, claudin-1 and occludin). Both the nutritional model and the genetic obesity model showed increased body weight and metabolic alterations at the final time point. An increase in intestinal ROS production and MPO activity was observed in the gastrointestinal tracts of rats fed a CAF diet but not in the genetic obesity model. TNF-α was overexpressed in the ileum of both CAF diet and fa/fa groups, and ileal inflammation was associated with the degree of obesity and metabolic alterations. Interestingly, the 17-week CAF group and the fa/fa rats exhibited alterations in the expressions of permeability genes. Relevantly, in the hyperlipidic refined sugar diet model of obesity, the responses to chronic energy overload led to time-dependent increases in gut inflammation and oxidative stress.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar General medicine Farmacia Engenharias iv Engenharias ii Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14752662

Direcció de correo del autor: ximena.terra@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat anna.ardevol@urv.cat

Identificador del autor: 0000-0003-1043-5844 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-0156-7538

Fecha de alta del registro: 2023-02-26

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/cafeteria-diet-triggers-intestinal-inflammation-and-oxidative-stress-in-obese-rats/36481830A5146F496471C39333F94D57

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: British Journal Of Nutrition. 117 (2): 218-229

Referencia de l'ítem segons les normes APA: Gil-Cardoso K, Ginés I, Pinent M, Ardévol A, Terra X, Blay M. (2017). A cafeteria diet triggers intestinal inflammation and oxidative stress in obese rats. British Journal Of Nutrition, 117(2), 218-229. DOI: 10.1017/S0007114516004608

DOI del artículo: 10.1017/s0007114516004608

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2017

Tipo de publicación: Journal Publications