Autor según el artículo: Gonzalez, Beatriz; Mas, Albert; Beltran, Gemma; Cullen, Paul J; Jesus Torija, Maria
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Beltran Casellas, Gemma / Mas Baron, Alberto / Torija Martínez, María Jesús
Palabras clave: Quorum sensing Pseudohyphal growth Mitochondria-to-nucleus pathway Krebs cycle Filamentous growth pseudohyphal growth mitochondria-to-nucleus pathway krebs cycle filamentous growth
Resumen: In yeast, ethanol is produced as a by-product of fermentation through glycolysis. Ethanol also stimulates a developmental foraging response called filamentous growth and is thought to act as a quorum-sensing molecule. Ethanol-inducible filamentous growth was examined in a small collection of wine/European strains, which validated ethanol as an inducer of filamentous growth. Wine strains also showed variability in their filamentation responses, which illustrates the striking phenotypic differences that can occur among individuals. Ethanol-inducible filamentous growth in 61278b strains was independent of several of the major filamentation regulatory pathways [including fMAPK, RAS-cAMP, Snf1, Rpd3(L), and Rim101] but required the mitochondrial retrograde (RTG) pathway, an inter-organellar signaling pathway that controls the nuclear response to defects in mitochondrial function. The RTG pathway regulated ethanol-dependent filamentous growth by maintaining flux through the TCA cycle. The ethanol-dependent invasive growth response required the polarisome and transcriptional induction of the cell adhesion molecule Flo11p. Our results validate established stimuli that trigger filamentous growth and show how stimuli can trigger highly specific responses among individuals. Our results also connect an inter-organellar pathway to a quorum sensing response in fungi.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Physiology (medical) Physiology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: gemma.beltran@urv.cat mjesus.torija@urv.cat albert.mas@urv.cat
Identificador del autor: 0000-0002-7071-205X 0000-0001-6419-0745 0000-0002-0763-1679
Fecha de alta del registro: 2024-10-12
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fphys.2017.00148/full
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Frontiers In Physiology. 8 (MAR): 148-
Referencia de l'ítem segons les normes APA: Gonzalez, Beatriz; Mas, Albert; Beltran, Gemma; Cullen, Paul J; Jesus Torija, Maria (2017). Role of Mitochondrial Retrograde Pathway in Regulating Ethanol-Inducible Filamentous Growth in Yeast. Frontiers In Physiology, 8(MAR), 148-. DOI: 10.3389/fphys.2017.00148
DOI del artículo: 10.3389/fphys.2017.00148
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2017
Tipo de publicación: Journal Publications