Articles producció científica> Psicologia

Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders

  • Datos identificativos

    Identificador: imarina:5131072
    Autores:
    Navarro, Silvia V.Alvarez, RobertoColomina, M. TeresaSanchez-Santed, FernandoFlores, PilarMoreno, Margarita
    Resumen:
    Psychogenic polydipsia, which is compulsive, non-regulatory fluid consumption, is present in 6%-20% of chronic psychiatric patients and frequently associated with the schizophrenia diagnosis. In the present study, we investigated the relation between schizophrenia-like symptoms and biomarkers with a compulsive drinking behavior phenotype in rats. Rats that were selected for low drinking vs high drinking behavior following schedule-induced polydipsia (SIP) were assessed in a latent inhibition (LI) paradigm using tone and electrical foot shock and in a spatial reversal learning task to evaluate behavioral inflexibility. We also analyzed the myelin basic protein in different brain areas of high drinker (HD) and low drinker (LD) rats. The HD rats, which were characterized by a compulsive drinking behavior on SIP, had a reduced level of LI effect and increased behavioral inflexibility in the spatial reversal learning task in comparison to the LD group. Moreover, HD rats showed less myelination in the center of the corpus callosum, striatum, and amygdala in comparison to LD rats. These findings strengthen the validity of HD rats that were selected by SIP as a possible phenotype of compulsive neuropsychiatric disorders, as evidenced by the existence of behaviors and biological markers that are related to schizophrenia and obsessive-compulsive disorder, including a reduced LI effect, behavioral inflexibility and reduced brain myelination. Future studies could contribute to the elucidation of the mechanisms underlying the compulsive phenotype of HD rats and its relation to vulnerability to schizophrenia.
  • Otros:

    Autor según el artículo: Navarro, Silvia V.; Alvarez, Roberto; Colomina, M. Teresa; Sanchez-Santed, Fernando; Flores, Pilar; Moreno, Margarita;
    Departamento: Psicologia
    Autor/es de la URV: Colomina Fosch, Maria Teresa
    Palabras clave: Schizophrenia Schedule-induced polydipsia Reversal learning Myelination Latent inhibition Compulsivity schedule-induced polydipsia reversal learning myelination latent inhibition compulsivity
    Resumen: Psychogenic polydipsia, which is compulsive, non-regulatory fluid consumption, is present in 6%-20% of chronic psychiatric patients and frequently associated with the schizophrenia diagnosis. In the present study, we investigated the relation between schizophrenia-like symptoms and biomarkers with a compulsive drinking behavior phenotype in rats. Rats that were selected for low drinking vs high drinking behavior following schedule-induced polydipsia (SIP) were assessed in a latent inhibition (LI) paradigm using tone and electrical foot shock and in a spatial reversal learning task to evaluate behavioral inflexibility. We also analyzed the myelin basic protein in different brain areas of high drinker (HD) and low drinker (LD) rats. The HD rats, which were characterized by a compulsive drinking behavior on SIP, had a reduced level of LI effect and increased behavioral inflexibility in the spatial reversal learning task in comparison to the LD group. Moreover, HD rats showed less myelination in the center of the corpus callosum, striatum, and amygdala in comparison to LD rats. These findings strengthen the validity of HD rats that were selected by SIP as a possible phenotype of compulsive neuropsychiatric disorders, as evidenced by the existence of behaviors and biological markers that are related to schizophrenia and obsessive-compulsive disorder, including a reduced LI effect, behavioral inflexibility and reduced brain myelination. Future studies could contribute to the elucidation of the mechanisms underlying the compulsive phenotype of HD rats and its relation to vulnerability to schizophrenia.
    Áreas temáticas: Saúde coletiva Psychology Psychiatry and mental health Psychiatry Psicología Medicine (all) Medicina ii Medicina i Materiais General medicine Farmacia Clinical neurology Ciencias sociales Ciências biológicas ii
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    Direcció de correo del autor: mariateresa.colomina@urv.cat
    Identificador del autor: 0000-0002-5619-4874
    Fecha de alta del registro: 2024-09-07
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://academic.oup.com/schizophreniabulletin/article/43/4/778/2548996
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Schizophrenia Bulletin. 43 (4): 778-787
    Referencia de l'ítem segons les normes APA: Navarro, Silvia V.; Alvarez, Roberto; Colomina, M. Teresa; Sanchez-Santed, Fernando; Flores, Pilar; Moreno, Margarita; (2017). Behavioral Biomarkers of Schizophrenia in High Drinker Rats: A Potential Endophenotype of Compulsive Neuropsychiatric Disorders. Schizophrenia Bulletin, 43(4), 778-787. DOI: 10.1093/schbul/sbw141
    DOI del artículo: 10.1093/schbul/sbw141
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2017
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Clinical Neurology,Psychiatry,Psychiatry and Mental Health
    Schizophrenia
    Schedule-induced polydipsia
    Reversal learning
    Myelination
    Latent inhibition
    Compulsivity
    schedule-induced polydipsia
    reversal learning
    myelination
    latent inhibition
    compulsivity
    Saúde coletiva
    Psychology
    Psychiatry and mental health
    Psychiatry
    Psicología
    Medicine (all)
    Medicina ii
    Medicina i
    Materiais
    General medicine
    Farmacia
    Clinical neurology
    Ciencias sociales
    Ciências biológicas ii
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