Autor según el artículo: Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona

Departamento: Bioquímica i Biotecnologia

e-ISSN: 2072-6643

Autor/es de la URV: Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / PONS VILA, ZARA

Palabras clave: Renin Protein hydrolysate Pressure Leg bone protein Hypertension Enzyme-inhibitory peptides Endothelial dysfunction Egg-white By-products Bioavailability Bioactive peptides Angiotensin-converting enzyme Angiotensin Ace-inhibitory activity hypertension endothelial dysfunction bioactive peptides angiotensin-converting enzyme ace-inhibitory activity

Resumen: The antihypertensive properties of different doses of a chicken foot hydrolysate, Hpp11 and the mechanisms involved in this effect were investigated. Spontaneously hypertensive rats (SHR) were administered water, Captopril (50 mg/kg) or Hpp11 at different doses (25, 55 and 85 mg/kg), and the systolic blood pressure (SBP) was recorded. The SBP of normotensive Wistar-Kyoto (WKY) rats administered water or Hpp11 was also recorded. Additionally, plasmatic angiotensin-converting enzyme (ACE) activity was determined in the SHR administered Hpp11. Moreover, the relaxation caused by Hpp11 in isolated aortic rings from Sprague-Dawley rats was evaluated. Hpp11 exhibited antihypertensive activity at doses of 55 and 85 mg/kg, with maximum activity 6 h post-administration. At this time, no differences were found between these doses and Captopril. Initial SBP values of 55 and 85 mg/kg were recovered 24 or 8 h post-administration, respectively, 55 mg/kg being the most effective dose. At this dose, a reduction in the plasmatic ACE activity in the SHR was found. However, Hpp11 did not relax the aortic ring preparations. Therefore, ACE inhibition could be the mechanism underlying Hpp11 antihypertensive effect. Remarkably, Hpp11 did not modify SBP in WKY rats, showing that the decreased SBP effect is specific to the hypertensive state.

Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

Direcció de correo del autor: franciscaisabel.bravo@urv.cat begona.muguerza@urv.cat

Identificador del autor: 0000-0002-6468-3088 0000-0001-7384-8588

Fecha de alta del registro: 2023-02-18

Volumen de revista: 10

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/2072-6643/10/9/1295

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrients. 10 (9):

Referencia de l'ítem segons les normes APA: Mas-Capdevila, Anna Pons, Zara Aleixandre, Amaya Bravo, Francisca I. Muguerza, Begona (2018). Dose-related antihypertensive properties and the corresponding mechanisms of a chicken foot hydrolysate in hypertensive rats. Nutrients, 10(9), -. DOI: 10.3390/nu10091295

DOI del artículo: 10.3390/nu10091295

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2018

Tipo de publicación: Journal Publications