Autor según el artículo: Papandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Toledo, Estefania; Dennis, Courtney; Deik, Amy; Clish, Clary; Razquin, Cristina; Corella, Dolores; Estruch, Ramon; Ros, Emilio; Fito, Montserrat; Aros, Fernando; Fiol, Miquel; Lapetra, Jose; Ruano, Cristina; Liang, Liming; Martinez-Gonzalez, Miguel A; Hu, Frank B; Salas-Salvado, Jordi
Departamento: Bioquímica i Biotecnologia
e-ISSN: 2072-6643
Autor/es de la URV: Bulló Bonet, Mònica / Salas Salvadó, Jorge
Palabras clave: Serum-lipids Risk Responses Predimed Plasma Nutritional epidemiology Middle aged Metabolomics Metaanalysis Male Identification Humans Female Drinking Cross-sectional studies Cohort studies Coffee Case-control studies Caffeine ingestion Caffeine Biomarkers Aged Acid predimed metabolomics coffee caffeine
Resumen: Few studies have examined the association of a wide range of metabolites with total and subtypes of coffee consumption. The aim of this study was to investigate associations of plasma metabolites with total, caffeinated, and decaffeinated coffee consumption. We also assessed the ability of metabolites to discriminate between coffee consumption categories. This is a cross-sectional analysis of 1664 participants from the PREDIMED study. Metabolites were semiquantitatively profiled using a multiplatform approach. Consumption of total coffee, caffeinated coffee and decaffeinated coffee was assessed by using a validated food frequency questionnaire. We assessed associations between 387 metabolite levels with total, caffeinated, or decaffeinated coffee consumption (≥50 mL coffee/day) using elastic net regression analysis. Ten-fold cross-validation analyses were used to estimate the discriminative accuracy of metabolites for total and subtypes of coffee. We identified different sets of metabolites associated with total coffee, caffeinated and decaffeinated coffee consumption. These metabolites consisted of lipid species (e.g., sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine) or were derived from glycolysis (alpha-glycerophosphate) and polyphenol metabolism (hippurate). Other metabolites included caffeine, 5-acetylamino-6-amino-3-methyluracil, cotinine, kynurenic acid, glycocholate, lactate, and allantoin. The area under the curve (AUC) was 0.60 (95% CI 0.56-0.64), 0.78 (95% CI 0.75-0.81) and 0.52 (95% CI 0.49-0.55), in the multimetabolite model, for total, caffeinated, and decaffeinated coffee consumption, respectively. Our comprehensive metabolic analysis did not result in a new, reliable potential set of metabolites for coffee consumption.
Áreas temáticas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 20726643
Direcció de correo del autor: monica.bullo@urv.cat jordi.salas@urv.cat
Identificador del autor: 0000-0002-0218-7046 0000-0003-2700-7459
Fecha de alta del registro: 2024-10-12
Volumen de revista: 11
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2072-6643/11/5/1032
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Nutrients. 11 (5): 1032-
Referencia de l'ítem segons les normes APA: Papandreou, Christopher; Hernandez-Alonso, Pablo; Bullo, Monica; Ruiz-Canela, Miguel; Yu, Edward; Guasch-Ferre, Marta; Toledo, Estefania; Dennis, Cour (2019). Plasma Metabolites Associated with Coffee Consumption: A Metabolomic Approach within the PREDIMED Study. Nutrients, 11(5), 1032-. DOI: 10.3390/nu11051032
DOI del artículo: 10.3390/nu11051032
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2019
Tipo de publicación: Journal Publications