Articles producció científica> Ciències Mèdiques Bàsiques

Primary prevention of cardiovascular disease with a Mediterranean diet

  • Datos identificativos

    Identificador: imarina:572059
    Handle: https://hdl.handle.net/20.500.11797/imarina572059
    Autores:
    Estruch, RamonRos, EmilioSalas-Salvado, JordiCovas, Maria-IsabelCorella, DoloresAros, FernandoGomez-Gracia, EnriqueRuiz-Gutierrez, ValentinaFiol, MiquelLapetra, JoseMaria Lamuela-Raventos, RosaSerra-Majem, LluisPinto, XavierBasora, JosepAngel Munoz, MiguelSorli, Jose VAlfredo Martinez, JoseAngel Martinez-Gonzalez, Miguel
    Resumen:
    Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events.In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). Participants received quarterly individual and group educational sessions and, depending on group assignment, free provision of extra-virgin olive oil, mixed nuts, or small nonfood gifts. The primary end point was the rate of major cardiovascular events (myocardial infarction, stroke, or death from cardiovascular causes). On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4.8 years.A total of 7447 persons were enrolled (age range, 55 to 80 years); 57% were women. The two Mediterranean-diet groups had good adherence to the intervention, according to self-reported intake and biomarker analyses. A primary end-point event occurred in 288 participants. The multivariable-adjusted hazard ratios were 0.70 (95% confidence interval [CI], 0.54 to 0.92) and 0.72 (95% CI, 0.54 to 0.96) for the group assigned to a Mediterranean diet with extra-virgin olive oil (96 events) and the group assigned to a Mediterranean diet with nuts (83 events), respectively, versus the control group (109 events). No diet-related adverse effects were reported.Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin ol

  • Otros:

    Autor según el artículo: Estruch, Ramon; Ros, Emilio; Salas-Salvado, Jordi; Covas, Maria-Isabel; Corella, Dolores; Aros, Fernando; Gomez-Gracia, Enrique; Ruiz-Gutierrez, Valentina; Fiol, Miquel; Lapetra, Jose; Maria Lamuela-Raventos, Rosa; Serra-Majem, Lluis; Pinto, Xavier; Basora, Josep; Angel Munoz, Miguel; Sorli, Jose V; Alfredo Martinez, Jose; Angel Martinez-Gonzalez, Miguel
    Departamento: Ciències Mèdiques Bàsiques Bioquímica i Biotecnologia
    Autor/es de la URV: Babio Sánchez, Nancy Elvira / Basora Gallisa, Josep / Bulló Bonet, Mònica / Cabre Vila, Juan Jose / Fernández Ballart, Joan Domènech / Martín Lujan, Francisco Manuel / Salas Salvadó, Jorge
    Palabras clave: Risk factors Nutrition Multivariate analysis Mortality Middle aged Male Humans Female Dietary supplements Aged, 80 and over Aged
    Resumen: Observational cohort studies and a secondary prevention trial have shown an inverse association between adherence to the Mediterranean diet and cardiovascular risk. We conducted a randomized trial of this diet pattern for the primary prevention of cardiovascular events.In a multicenter trial in Spain, we randomly assigned participants who were at high cardiovascular risk, but with no cardiovascular disease at enrollment, to one of three diets: a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). Participants received quarterly individual and group educational sessions and, depending on group assignment, free provision of extra-virgin olive oil, mixed nuts, or small nonfood gifts. The primary end point was the rate of major cardiovascular events (myocardial infarction, stroke, or death from cardiovascular causes). On the basis of the results of an interim analysis, the trial was stopped after a median follow-up of 4.8 years.A total of 7447 persons were enrolled (age range, 55 to 80 years); 57% were women. The two Mediterranean-diet groups had good adherence to the intervention, according to self-reported intake and biomarker analyses. A primary end-point event occurred in 288 participants. The multivariable-adjusted hazard ratios were 0.70 (95% confidence interval [CI], 0.54 to 0.92) and 0.72 (95% CI, 0.54 to 0.96) for the group assigned to a Mediterranean diet with extra-virgin olive oil (96 events) and the group assigned to a Mediterranean diet with nuts (83 events), respectively, versus the control group (109 events). No diet-related adverse effects were reported.Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events. (Funded by the Spanish government's Instituto de Salud Carlos III and others; Controlled-Trials.com number, ISRCTN35739639.).
    Áreas temáticas: Saúde coletiva Psicología Odontología Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General o multidisciplinar General medicine Farmacia Ensino Engenharias iv Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15334406
    Direcció de correo del autor: juanjose.cabre@urv.cat josep.basora@urv.cat paco.martin@urv.cat monica.bullo@urv.cat josep.basora@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Identificador del autor: 0000-0003-1082-6861 0000-0003-0359-3588 0000-0002-0218-7046 0000-0003-2700-7459 0000-0003-3527-5277
    Fecha de alta del registro: 2024-10-12
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.nejm.org/doi/10.1056/NEJMoa1200303
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: New England Journal Of Medicine. 368 (14): 1279-1290
    Referencia de l'ítem segons les normes APA: Estruch, Ramon; Ros, Emilio; Salas-Salvado, Jordi; Covas, Maria-Isabel; Corella, Dolores; Aros, Fernando; Gomez-Gracia, Enrique; Ruiz-Gutierrez, Valen (2013). Primary prevention of cardiovascular disease with a Mediterranean diet. New England Journal Of Medicine, 368(14), 1279-1290. DOI: 10.1056/NEJMoa1200303
    DOI del artículo: 10.1056/NEJMoa1200303
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2013
    Tipo de publicación: Journal Publications

  • Palabras clave:

    Medicine (Miscellaneous),Medicine, General & Internal
    Risk factors
    Nutrition
    Multivariate analysis
    Mortality
    Middle aged
    Male
    Humans
    Female
    Dietary supplements
    Aged, 80 and over
    Aged
    Saúde coletiva
    Psicología
    Odontología
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General o multidisciplinar
    General medicine
    Farmacia
    Ensino
    Engenharias iv
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología

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