Autor según el artículo: Ballesteros, Monica; Simon, Inmaculada; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; Miralles, Ramon M.; Albaiges, Gerard; Tinahones, Francisco; Megia, Ana;
Departamento: Medicina i Cirurgia
Autor/es de la URV: Albaigès Baiget, Gerard / Ballesteros Pérez, Monica / Ceperuelo Mallafré, Maria Victoria / Megía Colet, Ana / MIRALLES PI, RAMÓN MARÍA / Simón Muela, María Inmaculada / Vendrell Ortega, Juan José
Palabras clave: Birth-weight Expression Glucose Insulin-resistance Plasma adiponectin Serum adiponectin
Resumen: OBJECTIVE-To analyze the relationship between maternal adiponectin (mAdiponectin) and cord blood adiponectin (cbAdiponectin) multimeric forms (high molecular weight [HMW], medium molecular weight [MMW], and low molecular weight [LMW]) in a cohort of gestational diabetes mellitus (GDM) and normal glucose-tolerant (NGT) pregnant women.
RESEARCH DESIGN AND METHODS-A total of 212 women with a singleton pregnancy, 132 with NGT and 80 with GDM, and their offspring were studied. Maternal blood was obtained in the early third trimester and cord blood was obtained at delivery. Total adiponectin and the multimeric forms of adiponectin were determined in cord blood and maternal serum. Spearman rank correlation and stepwise linear correlation analysis were used to assess the relationship between cbAdiponectin levels and clinical and analytical parameters.
RESULTS-No differences in cbAdiponectin concentration or its multimeric forms were observed in the offspring of diabetic mothers compared with NGT mothers. The HMW-to-total adiponectin ratio was higher in cord blood than in maternal serum, whereas the MMW- and LMW-to-total adiponectin ratio was lower. Cord blood total and HMW adiponectin levels were positively correlated with birth weight and the ponderal index (PI), whereas cord blood MMW adiponectin was negatively correlated with the PI. In addition, cbAdiponectin and its multimeric forms were correlated with mAdiponectin concentrations. In the multivariate analysis, maternal multimeric forms of adiponectin emerged as independent predictors of cbAdiponectin, its multimers, and their distribution.
CONCLUSIONS-cbAdiponectin concentrations are independently related to mAdiponectin levels and unrelated to the diagnosis of GDM. Maternal multimeric forms of adiponectin are independent predictors of the concentrations of cbAdiponectin and its multimeric forms at delivery.
Áreas temáticas: Advanced and specialized nursing Antropologia / arqueologia Biotecnología Ciências biológicas i Ciências biológicas ii Endocrinology & metabolism Endocrinology, diabetes and metabolism Enfermagem Engenharias iv General medicine Interdisciplinar Internal medicine Medicina i Medicina ii Medicina iii Nutrição Odontología Saúde coletiva
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
Direcció de correo del autor: ana.megia@urv.cat juanjose.vendrell@urv.cat victoria.ceperuelo@urv.cat monica.ballesteros@urv.cat
Identificador del autor: 0000-0002-5101-9452 0000-0002-6994-6115 0000-0002-4460-9761
Fecha de alta del registro: 2023-10-07
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://diabetesjournals.org/care/article/34/11/2418/28907/Maternal-and-Cord-Blood-Adiponectin-Multimeric
Referencia al articulo segun fuente origial: Diabetes Care. 34 (11): 2418-2423
Referencia de l'ítem segons les normes APA: Ballesteros, Monica; Simon, Inmaculada; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; Miralles, Ramon M.; Albaiges, Gerard; Tinahones, Francisco; Megi (2011). Maternal and Cord Blood Adiponectin Multimeric Forms in Gestational Diabetes Mellitus: A prospective analysis . Diabetes Care, 34(11), 2418-2423. DOI: 10.2337/dc11-0788
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.2337/dc11-0788
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2011
Tipo de publicación: Journal Publications
Repositori URV