Autor según el artículo: Ramos-Romero, Sara; Hereu, Merce; Atienza, Lidia; Amezqueta, Susana; Casas, Josefina; Munoz, Silvia; Medina, Isabel; Miralles-Perez, Bernat; Romeu, Marta; Torres, Josep L.;
Departamento: Ciències Mèdiques Bàsiques
Autor/es de la URV: Miralles Pérez, Bernat / Romeu Ferran, Marta
Palabras clave: Resistance Obesity Metabolism Metabolic syndrome Leptin Fructose Food Diet Diabetes D-fagomine Blood pressure fructose diabetes d-fagomine blood pressure
Resumen: Scope This study examines the long-term functional effects of d-fagomine on sucrose-induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35% sucrose solution with d-fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F-2t isoprostanes (F-2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F-2-IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention. Conclusion d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 16134125
Direcció de correo del autor: bmirallesperez@gmail.com marta.romeu@urv.cat
Identificador del autor: 0000-0003-1294-7069 0000-0002-2131-1858
Fecha de alta del registro: 2024-10-19
Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 64 (1): e1900564-
Referencia de l'ítem segons les normes APA: Ramos-Romero, Sara; Hereu, Merce; Atienza, Lidia; Amezqueta, Susana; Casas, Josefina; Munoz, Silvia; Medina, Isabel; Miralles-Perez, Bernat; Romeu, Ma (2020). The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. Molecular Nutrition & Food Research, 64(1), e1900564-. DOI: 10.1002/mnfr.201900564
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV