Articles producció científica> Ciències Mèdiques Bàsiques

The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats

  • Datos identificativos

    Identificador: imarina:6003796
    Autores:
    Ramos-Romero, SaraHereu, MerceAtienza, LidiaAmezqueta, SusanaCasas, JosefinaMunoz, SilviaMedina, IsabelMiralles-Perez, BernatRomeu, MartaTorres, Josep L.
    Resumen:
    Scope This study examines the long-term functional effects of d-fagomine on sucrose-induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35% sucrose solution with d-fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F-2t isoprostanes (F-2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F-2-IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention. Conclusion d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
  • Otros:

    Autor según el artículo: Ramos-Romero, Sara; Hereu, Merce; Atienza, Lidia; Amezqueta, Susana; Casas, Josefina; Munoz, Silvia; Medina, Isabel; Miralles-Perez, Bernat; Romeu, Marta; Torres, Josep L.;
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Miralles Pérez, Bernat / Romeu Ferran, Marta
    Palabras clave: Resistance Obesity Metabolism Metabolic syndrome Leptin Fructose Food Diet Diabetes D-fagomine Blood pressure fructose diabetes d-fagomine blood pressure
    Resumen: Scope This study examines the long-term functional effects of d-fagomine on sucrose-induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35% sucrose solution with d-fagomine (or not, for comparison) or mineral water (controls) for 24 weeks. The following are recorded: body weight; energy intake; glucose tolerance; plasma leptin concentration and lipid profile; populations of Bacteroidetes, Firmicutes, bacteroidales, clostridiales, enterobacteriales, and Escherichia coli in feces; blood pressure; urine uric acid and F-2t isoprostanes (F-2-IsoPs); perigonadal fat deposition; and hepatic histology and diacylglycerols (DAGs) in liver and adipose tissue. d-Fagomine reduces sucrose-induced hypertension, urine uric acid and F-2-IsoPs (markers of oxidative stress), steatosis, and liver DAGs, without significantly affecting perigonadal fat deposition, and impaired glucose tolerance. It also promotes excretion of enterobacteriales generated by the dietary intervention. Conclusion d-fagomine counteracts sucrose-induced steatosis and hypertension, presumably by reducing the postprandial levels of fructose in the liver.
    Áreas temáticas: Saúde coletiva Química Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología Biotechnology Astronomia / física
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 16134125
    Direcció de correo del autor: bmirallesperez@gmail.com marta.romeu@urv.cat
    Identificador del autor: 0000-0003-1294-7069 0000-0002-2131-1858
    Fecha de alta del registro: 2024-10-19
    Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion
    Enlace a la fuente original: https://onlinelibrary.wiley.com/doi/full/10.1002/mnfr.201900564
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Molecular Nutrition & Food Research. 64 (1): e1900564-
    Referencia de l'ítem segons les normes APA: Ramos-Romero, Sara; Hereu, Merce; Atienza, Lidia; Amezqueta, Susana; Casas, Josefina; Munoz, Silvia; Medina, Isabel; Miralles-Perez, Bernat; Romeu, Ma (2020). The Buckwheat Iminosugar d-Fagomine Attenuates Sucrose-Induced Steatosis and Hypertension in Rats. Molecular Nutrition & Food Research, 64(1), e1900564-. DOI: 10.1002/mnfr.201900564
    DOI del artículo: 10.1002/mnfr.201900564
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biotechnology,Food Science,Food Science & Technology
    Resistance
    Obesity
    Metabolism
    Metabolic syndrome
    Leptin
    Fructose
    Food
    Diet
    Diabetes
    D-fagomine
    Blood pressure
    fructose
    diabetes
    d-fagomine
    blood pressure
    Saúde coletiva
    Química
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biotechnology
    Astronomia / física
  • Documentos:

  • Cerca a google

    Search to google scholar