Articles producció científica> Ciències Mèdiques Bàsiques

TWEAK MODULATES TNFALPHA INDUCED CYTOKINE PRODUCTION IN HUMAN ADIPOCYTES

  • Datos identificativos

    Identificador: imarina:6157350
    Autores:
    Rodriguez Chacon, M.Maymo-Masip, E.Fernandez-Veledo, S.Garcia-Espana, A.Vazquez-Carballo, A.Tinahones, F.Garcia-Fuentes, E.Wabitsch, M.Vendrell, J.
    Resumen:
    Obesity and type 2 diabetes (T2D) are associated with chronic low-grade inflammation. Mounting evidence suggests the involvement of an inflammatory switch in adipose tissue, both in mature adipocytes and immune-competent cells from the stromal vascular compartment, in the progression of obesity and insulin resistance. Several inflammatory cytokines secreted by obese adipose tissue, including TNFα and IL-6 have been described as hallmark molecules involved in this process, impairing insulin signaling in insulin-responsive organs. An increasing number of new molecules affecting the local and systemic inflammatory imbalance in obesity and T2D have been identified. In this complex condition, some molecules may exhibit opposing actions, depending on the cell type and on systemic or local influences. Tumor necrosis factor weak inducer of apoptosis (TWEAK), a cytokine of the tumor necrosis (TNF) superfamily, is gaining attention as an important player in chronic inflammatory diseases. TWEAK can exist as a full-length membrane-associated (mTWEAK) form and as a soluble (sTWEAK) form and, by acting through its cognate receptor Fn14, can control many cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. Notably, sTWEAK has been proposed as a biomarker of cardiovascular diseases. Here, we will review the recent findings relating to TWEAK and its receptor within the context of obesity and the associated disorder T2D.
  • Otros:

    Autor según el artículo: Rodriguez Chacon, M.; Maymo-Masip, E.; Fernandez-Veledo, S.; Garcia-Espana, A.; Vazquez-Carballo, A.; Tinahones, F.; Garcia-Fuentes, E.; Wabitsch, M.; Vendrell, J.;
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: Fernandez Veledo, Sonia
    Palabras clave: @infoAeu @residentesaeu @uroweb Etiqueta «#» Hashtag
    Resumen: Obesity and type 2 diabetes (T2D) are associated with chronic low-grade inflammation. Mounting evidence suggests the involvement of an inflammatory switch in adipose tissue, both in mature adipocytes and immune-competent cells from the stromal vascular compartment, in the progression of obesity and insulin resistance. Several inflammatory cytokines secreted by obese adipose tissue, including TNFα and IL-6 have been described as hallmark molecules involved in this process, impairing insulin signaling in insulin-responsive organs. An increasing number of new molecules affecting the local and systemic inflammatory imbalance in obesity and T2D have been identified. In this complex condition, some molecules may exhibit opposing actions, depending on the cell type and on systemic or local influences. Tumor necrosis factor weak inducer of apoptosis (TWEAK), a cytokine of the tumor necrosis (TNF) superfamily, is gaining attention as an important player in chronic inflammatory diseases. TWEAK can exist as a full-length membrane-associated (mTWEAK) form and as a soluble (sTWEAK) form and, by acting through its cognate receptor Fn14, can control many cellular activities including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. Notably, sTWEAK has been proposed as a biomarker of cardiovascular diseases. Here, we will review the recent findings relating to TWEAK and its receptor within the context of obesity and the associated disorder T2D.
    Áreas temáticas: Saúde coletiva Química Psicología Pharmacology & pharmacy Pharmacology Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology Farmacia Engenharias iv Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Chemistry Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 10233830
    Direcció de correo del autor: sonia.fernandez@urv.cat
    Identificador del autor: 0000-0003-2906-3788
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874549/
    Referencia al articulo segun fuente origial: Inflammation Research. 60 95-95
    Referencia de l'ítem segons les normes APA: Rodriguez Chacon, M.; Maymo-Masip, E.; Fernandez-Veledo, S.; Garcia-Espana, A.; Vazquez-Carballo, A.; Tinahones, F.; Garcia-Fuentes, E.; Wabitsch, M.; (2011). TWEAK MODULATES TNFALPHA INDUCED CYTOKINE PRODUCTION IN HUMAN ADIPOCYTES. Inflammation Research, 60(), 95-95
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    DOI del artículo: 10.3389/fimmu.2013.00488
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2011
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Biochemistry & Molecular Biology,Cell Biology,Chemistry,Immunology,Pharmacology,Pharmacology & Pharmacy
    Saúde coletiva
    Química
    Psicología
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Immunology
    Farmacia
    Engenharias iv
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Chemistry
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
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