Autor según el artículo: Rojo-Martínez G; Maymó-Masip E; Mar Rodríguez M; Solano E; Goday A; Soriguer F; Valdés S; Chaves F; Delgado E; Colomo N; Hernández P; Vendrell J; Chacón M

Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia

Autor/es de la URV: Maymo Masip, Elsa / Vendrell Ortega, Juan José

Palabras clave: Weight-loss Weak inducer Tweak Tnf-alpha Soluble cd163 Obesity Metabolic syndrome Mediterranean diet Inflammation High cardiovascular risk

Resumen: Objective: Serum levels of soluble TNF-like weak inducer of apoptosis (sTWEAK) and its scavenger receptor CD163 (sCD163) have been linked to insulin resistance. We analysed the usefulness of these cytokines as biomarkers of type 2 diabetes in a Spanish cohort, together with their relationship to food consumption in the setting of the Di@bet.es study. Research Design and Methods: This is a cross-sectional, matched case-control study of 514 type 2 diabetes subjects and 517 controls with a Normal Oral Glucose Tolerance Test (NOGTT), using data from the Di@bet.es study. Study variables included clinical and demographic structured survey, food frequency questionnaire and physical examination. Serum concentrations of sTWEAK and sCD163 were measured by ELISA. Linear regression analysis determined which variables were related to sTWEAK and sCD163 levels. Logistic regression analysis was used to estimate odd ratios of presenting type 2 diabetes. Results: sCD163 concentrations and sCD163/sTWEAK ratio were 11.0% and 15.0% higher, respectively, (P<0.001) in type 2 diabetes than in controls. Following adjustment for various confounders, the OR for presenting type 2 diabetes in subjects in the highest vs the lowest tertile of sCD163 was [(OR), 2,01 (95%CI, 1,46-2,97); P for trend <0.001]. Coffee and red wine consumption was negatively associated with serum levels of sCD163 (P = 0.0001 and; P = 0.002 for coffee and red wine intake, respectively). Conclusions: High circulating levels of sCD163 are associated with type 2 diabetes in the Spanish population. The association between coffee and red wine intake and these biomarkers deserves further study to confirm its potential role in type 2 diabetes. © 2014 Rojo-Martínez et al.

Áreas temáticas: Zootecnia / recursos pesqueiros Sociology Sociología Serviço social Saúde coletiva Química Psychology Psicología Planejamento urbano e regional / demografia Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Linguística e literatura Letras / linguística Interdisciplinary research in the social sciences Interdisciplinar Human geography and urban studies History & philosophy of science Historia Geografía Geociências General medicine General biochemistry,genetics and molecular biology General agricultural and biological sciences Farmacia Environmental studies Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Educação Economia Direito Demography Comunicação e informação Ciências sociais aplicadas i Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência política e relações internacionais Ciência de alimentos Ciência da computação Biotecnología Biology Biodiversidade Biochemistry, genetics and molecular biology (miscellaneous) Astronomia / física Arquitetura, urbanismo e design Archaeology Antropologia / arqueologia Anthropology Agricultural and biological sciences (miscellaneous) Administração, ciências contábeis e turismo Administração pública e de empresas, ciências contábeis e turismo

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 19326203

Direcció de correo del autor: elsa.maymo@urv.cat juanjose.vendrell@urv.cat

Identificador del autor: 0000-0002-9133-3120 0000-0002-6994-6115

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101250

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Plos One. 9 (6): e101250-

Referencia de l'ítem segons les normes APA: Rojo-Martínez G; Maymó-Masip E; Mar Rodríguez M; Solano E; Goday A; Soriguer F; Valdés S; Chaves F; Delgado E; Colomo N; Hernández P; Vendrell J; Chac (2014). Serum sCD163 levels are associated with type 2 diabetes mellitus and are influenced by coffee and wine consumption: Results of the di@bet.es study. Plos One, 9(6), e101250-. DOI: 10.1371/journal.pone.0101250

DOI del artículo: 10.1371/journal.pone.0101250

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2014

Tipo de publicación: Journal Publications