Articles producció científica> Ciències Mèdiques Bàsiques

Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine

  • Datos identificativos

    Identificador: imarina:6388005
    Autores:
    García-Minguillán CFernandez-Ballart JCeruelo SRíos LBueno OBerrocal-Zaragoza MMolloy AUeland PMeyer KMurphy M
    Resumen:
    © 2014, Springer-Verlag Berlin Heidelberg. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524C>T polymorphisms on homocysteine are unclear. We tested the hypothesis that the effects of the MTHFR 677C>T, MTRR 66A>G and MTRR 524C>T polymorphisms on fasting plasma total homocysteine (tHcy) depend on riboflavin status (erythrocyte glutathionine reductase activation coefficient, optimum: <1.2; marginally deficient: 1.2–1.4; deficient: ≥1.4) in 771 adults aged 18–75 years. MTHFR 677T allele carriers with middle or low tertile plasma folate (<14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p < 0.01). This effect was eliminated when riboflavin status was optimal (p for interaction: 0.048). In the lowest cobalamin quartile (≤273 pmol/L), riboflavin status modifies the relationship between the MTRR 66 A>G polymorphism and tHcy (p for interaction: 0.034). tHcy was 6.6 % higher in MTRR 66G allele carriers compared to the 66AA genotype with marginally deficient or optimal riboflavin status, but there was no difference when riboflavin status was deficient (p for interaction: 0.059). tHcy was 13.7 % higher in MTRR 524T allele carriers compared to the 524CC genotype when cobalamin status was low (p < 0.01), but no difference was observed when we stratified by riboflavin status. The effect of the MTHFR 677C>T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A>G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C>T polymorphism on cobalamin status.
  • Otros:

    Autor según el artículo: García-Minguillán C; Fernandez-Ballart J; Ceruelo S; Ríos L; Bueno O; Berrocal-Zaragoza M; Molloy A; Ueland P; Meyer K; Murphy M
    Departamento: Ciències Mèdiques Bàsiques
    Autor/es de la URV: BERROCAL ZARAGOZA, MA. ISABEL / BUENO FRAILE, OLALLA / CERUELO CARO, SANTIAGO / Fernández Ballart, Joan Domènech / GARCIA MINGUILLÁN DEL CAMPO, CARLOS JESÚS / Murphy, Michelle
    Palabras clave: Vitamin b6 Riboflavin Mtrr Mthfr Homocysteine Egrac Eastac
    Resumen: © 2014, Springer-Verlag Berlin Heidelberg. Methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), riboflavin-dependent enzymes, participate in homocysteine metabolism. Reported effects of riboflavin status on the association between the MTHFR 677C>T polymorphism and homocysteine vary, and the effects of the MTRR 66A>G or MTRR 524C>T polymorphisms on homocysteine are unclear. We tested the hypothesis that the effects of the MTHFR 677C>T, MTRR 66A>G and MTRR 524C>T polymorphisms on fasting plasma total homocysteine (tHcy) depend on riboflavin status (erythrocyte glutathionine reductase activation coefficient, optimum: <1.2; marginally deficient: 1.2–1.4; deficient: ≥1.4) in 771 adults aged 18–75 years. MTHFR 677T allele carriers with middle or low tertile plasma folate (<14.7 nmol/L) had 8.2 % higher tHcy compared to the 677CC genotype (p < 0.01). This effect was eliminated when riboflavin status was optimal (p for interaction: 0.048). In the lowest cobalamin quartile (≤273 pmol/L), riboflavin status modifies the relationship between the MTRR 66 A>G polymorphism and tHcy (p for interaction: 0.034). tHcy was 6.6 % higher in MTRR 66G allele carriers compared to the 66AA genotype with marginally deficient or optimal riboflavin status, but there was no difference when riboflavin status was deficient (p for interaction: 0.059). tHcy was 13.7 % higher in MTRR 524T allele carriers compared to the 524CC genotype when cobalamin status was low (p < 0.01), but no difference was observed when we stratified by riboflavin status. The effect of the MTHFR 677C>T polymorphism on tHcy depends on riboflavin status, that of the MTRR 66A>G polymorphism on cobalamin and riboflavin status and that of the MTRR 524C>T polymorphism on cobalamin status.
    Áreas temáticas: Zootecnia / recursos pesqueiros Nutrition & dietetics Nutrição Medicina ii Medicina i Interdisciplinar Genetics & heredity Genetics Endocrinology, diabetes and metabolism Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 15558932
    Direcció de correo del autor: michelle.murphy@urv.cat
    Identificador del autor: 0000-0002-6304-6204
    Fecha de alta del registro: 2024-10-05
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://link.springer.com/article/10.1007/s12263-014-0435-1#citeas
    URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Genes And Nutrition. 9 (6):
    Referencia de l'ítem segons les normes APA: García-Minguillán C; Fernandez-Ballart J; Ceruelo S; Ríos L; Bueno O; Berrocal-Zaragoza M; Molloy A; Ueland P; Meyer K; Murphy M (2014). Riboflavin status modifies the effects of methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) polymorphisms on homocysteine. Genes And Nutrition, 9(6), -. DOI: 10.1007/s12263-014-0435-1
    DOI del artículo: 10.1007/s12263-014-0435-1
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2014
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Endocrinology, Diabetes and Metabolism,Genetics,Genetics & Heredity,Nutrition & Dietetics
    Vitamin b6
    Riboflavin
    Mtrr
    Mthfr
    Homocysteine
    Egrac
    Eastac
    Zootecnia / recursos pesqueiros
    Nutrition & dietetics
    Nutrição
    Medicina ii
    Medicina i
    Interdisciplinar
    Genetics & heredity
    Genetics
    Endocrinology, diabetes and metabolism
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biotecnología
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