Autor según el artículo: Hernández-Alonso P; Salas-Salvadó J; Baldrich-Mora M; Mallol R; Correig X; Bulló M

Departamento: Enginyeria Electrònica, Elèctrica i Automàtica Bioquímica i Biotecnologia

Autor/es de la URV: Bulló Bonet, Mònica / Correig Blanchar, Francesc Xavier / MALLOL PARERA, ROGER / Salas Salvadó, Jorge

Palabras clave: Pre-diabetes Pistachios Lipoprotein Dietary intervention Clinical trial Cardiovascular disease pistachios lipoprotein dietary intervention clinical trial cardiovascular disease

Resumen: © 2015 Elsevier B.V. Background and aims: Nuts have been demonstrated to improve several cardiovascular risk factors and the lipid profile in diabetic and pre-diabetic subjects. However, analysis of conventional serum lipid profiles does not completely explain the atherogenic risk associated with pre-diabetes. We therefore investigated whether chronic consumption of pistachio modifies the lipoprotein subclasses to a healthier profile in pre-diabetic subjects. Methods and results: Randomized cross-over clinical trial in 54 subjects with pre-diabetes. Subjects consumed a pistachio-supplemented diet (PD, 50% carbohydrates, 33% fat, including 57g/d of pistachios daily) and a control diet (CD, 55% carbohydrates, 30% fat) for 4 months each, separated by a 2-week wash-out. Diets were isocaloric and matched for protein, fiber and saturated fatty acids. Nuclear magnetic resonance (NMR) was performed to determine changes in plasma lipoprotein subclasses. Small low-density lipoprotein particles (sLDL-P) significantly decreased after pistachio consumption compared to the nut-free diet (P=0.023). The non-high-density lipoprotein particles (non-HDL-P i.e. VLDL-P plus LDL-P) significantly decreased under the PD compared to CD (P=0.041). The percentage of sHDL-P increased by 2.23% after the PD compared with a reduction of 0.08% after the CD (P=0.014). Consequently, the overall size of HDL-P significantly decreased in the PD (P=0.007). Conclusion: Chronic pistachio consumption could modify the lipoprotein particle size and subclass concentrations independently of changes in total plasma lipid profile, which may help to explain the decreased risk of cardiovascular disease and mortality associated with those individuals who frequently consumed nuts.

Áreas temáticas: Serviço social Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Enfermagem Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Cardiology and cardiovascular medicine Cardiac & cardiovascular systems

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 15903729

Direcció de correo del autor: xavier.correig@urv.cat jordi.salas@urv.cat monica.bullo@urv.cat

Identificador del autor: 0000-0002-6902-3054 0000-0003-2700-7459 0000-0002-0218-7046

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/acceptedVersion

Enlace a la fuente original: https://www.nmcd-journal.com/article/S0939-4753(15)00031-9/fulltext

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Nutrition Metabolism And Cardiovascular Diseases. 25 (4): 396-402

Referencia de l'ítem segons les normes APA: Hernández-Alonso P; Salas-Salvadó J; Baldrich-Mora M; Mallol R; Correig X; Bulló M (2015). Effect of pistachio consumption on plasma lipoprotein subclasses in pre-diabetic subjects. Nutrition Metabolism And Cardiovascular Diseases, 25(4), 396-402. DOI: 10.1016/j.numecd.2015.01.013

DOI del artículo: 10.1016/j.numecd.2015.01.013

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2015

Tipo de publicación: Journal Publications