Articles producció científica> Bioquímica i Biotecnologia

Nickel nanoparticles induce the synthesis of a tumor-related polypeptide in human epidermal keratinocytes

  • Datos identificativos

    Identificador: imarina:6390178
    Handle: http://hdl.handle.net/20.500.11797/imarina6390178
  • Autores:

    Jiménez-Lamana J
    Godin S
    Aragonès G
    Bladé C
    Szpunar J
    Łobinski R
  • Otros:

    Autor según el artículo: Jiménez-Lamana J; Godin S; Aragonès G; Bladé C; Szpunar J; Łobinski R
    Departamento: Bioquímica i Biotecnologia
    Autor/es de la URV: Aragonès Bargalló, Gerard / BLADÉ SEGARRA, MARIA CINTA
    Palabras clave: Toxicity Skin Silver nanoparticles Protein induction Nickel nanoparticles Molecular-mechanisms Mass-spectrometry Human keratinocytes High resolution mass spectrometry Cytotoxicity Culture-medium Chemical carcinogens Cells Bioaccumulation nickel nanoparticles human keratinocytes high resolution mass spectrometry cytotoxicity
    Resumen: © 2020 by the authors. Although nickel allergy and carcinogenicity are well known, their molecular mechanisms are still uncertain, thus demanding studies at the molecular level. The nickel carcinogenicity is known to be dependent on the chemical form of nickel, since only certain nickel compounds can enter the cell. This study investigates, for the first time, the cytotoxicity, cellular uptake, and molecular targets of nickel nanoparticles (NiNPs) in human skin cells in comparison with other chemical forms of nickel. The dose-response curve that was obtained for NiNPs in the cytotoxicity assays showed a linear behavior typical of genotoxic carcinogens. The exposure of keratinocytes to NiNPs leads to the release of Ni2+ ions and its accumulation in the cytosol. A 6 kDa nickel-binding molecule was found to be synthesized by cells exposed to NiNPs at a dose corresponding to medium mortality. This molecule was identified to be tumor-related p63-regulated gene 1 protein.
    Áreas temáticas: Physics, applied Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) General materials science General chemical engineering Engenharias ii Chemistry, multidisciplinary Chemical engineering (miscellaneous) Chemical engineering (all)
    Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
    ISSN: 2079-4991
    Direcció de correo del autor: gerard.aragones@urv.cat
    Fecha de alta del registro: 2023-02-19
    Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
    Enlace a la fuente original: https://www.mdpi.com/2079-4991/10/5/992
    URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/
    Referencia al articulo segun fuente origial: Nanomaterials. 10 (5):
    Referencia de l'ítem segons les normes APA: Jiménez-Lamana J; Godin S; Aragonès G; Bladé C; Szpunar J; Łobinski R (2020). Nickel nanoparticles induce the synthesis of a tumor-related polypeptide in human epidermal keratinocytes. Nanomaterials, 10(5), -. DOI: 10.3390/nano10050992
    DOI del artículo: 10.3390/nano10050992
    Entidad: Universitat Rovira i Virgili
    Año de publicación de la revista: 2020
    Tipo de publicación: Journal Publications
  • Palabras clave:

    Chemical Engineering (Miscellaneous),Chemistry, Multidisciplinary,Materials Science (Miscellaneous),Materials Science, Multidisciplinary,Nanoscience & Nanotechnology,Physics, Applied
    Toxicity
    Skin
    Silver nanoparticles
    Protein induction
    Nickel nanoparticles
    Molecular-mechanisms
    Mass-spectrometry
    Human keratinocytes
    High resolution mass spectrometry
    Cytotoxicity
    Culture-medium
    Chemical carcinogens
    Cells
    Bioaccumulation
    nickel nanoparticles
    human keratinocytes
    high resolution mass spectrometry
    cytotoxicity
    Physics, applied
    Nanoscience & nanotechnology
    Materials science, multidisciplinary
    Materials science (miscellaneous)
    Materials science (all)
    General materials science
    General chemical engineering
    Engenharias ii
    Chemistry, multidisciplinary
    Chemical engineering (miscellaneous)
    Chemical engineering (all)
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