Autor según el artículo: Jiménez-Lamana J; Godin S; Aragonès G; Bladé C; Szpunar J; Łobinski R
Departamento: Bioquímica i Biotecnologia
Autor/es de la URV: Aragonès Bargalló, Gerard / BLADÉ SEGARRA, MARIA CINTA
Palabras clave: Toxicity Skin Silver nanoparticles Protein induction Nickel nanoparticles Molecular-mechanisms Mass-spectrometry Human keratinocytes High resolution mass spectrometry Cytotoxicity Culture-medium Chemical carcinogens Cells Bioaccumulation nickel nanoparticles human keratinocytes high resolution mass spectrometry cytotoxicity
Resumen: © 2020 by the authors. Although nickel allergy and carcinogenicity are well known, their molecular mechanisms are still uncertain, thus demanding studies at the molecular level. The nickel carcinogenicity is known to be dependent on the chemical form of nickel, since only certain nickel compounds can enter the cell. This study investigates, for the first time, the cytotoxicity, cellular uptake, and molecular targets of nickel nanoparticles (NiNPs) in human skin cells in comparison with other chemical forms of nickel. The dose-response curve that was obtained for NiNPs in the cytotoxicity assays showed a linear behavior typical of genotoxic carcinogens. The exposure of keratinocytes to NiNPs leads to the release of Ni2+ ions and its accumulation in the cytosol. A 6 kDa nickel-binding molecule was found to be synthesized by cells exposed to NiNPs at a dose corresponding to medium mortality. This molecule was identified to be tumor-related p63-regulated gene 1 protein.
Áreas temáticas: Physics, applied Nanoscience & nanotechnology Materials science, multidisciplinary Materials science (miscellaneous) Materials science (all) General materials science General chemical engineering Engenharias ii Chemistry, multidisciplinary Chemical engineering (miscellaneous) Chemical engineering (all)
Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/
ISSN: 2079-4991
Direcció de correo del autor: gerard.aragones@urv.cat
Fecha de alta del registro: 2023-02-19
Versión del articulo depositado: info:eu-repo/semantics/publishedVersion
Enlace a la fuente original: https://www.mdpi.com/2079-4991/10/5/992
Referencia al articulo segun fuente origial: Nanomaterials. 10 (5):
Referencia de l'ítem segons les normes APA: Jiménez-Lamana J; Godin S; Aragonès G; Bladé C; Szpunar J; Łobinski R (2020). Nickel nanoparticles induce the synthesis of a tumor-related polypeptide in human epidermal keratinocytes. Nanomaterials, 10(5), -. DOI: 10.3390/nano10050992
URL Documento de licencia: https://repositori.urv.cat/ca/proteccio-de-dades/
DOI del artículo: 10.3390/nano10050992
Entidad: Universitat Rovira i Virgili
Año de publicación de la revista: 2020
Tipo de publicación: Journal Publications
Repositori URV