Autor según el artículo: Montalvo, Itziar; Gonzalez-Rodriguez, Alexandre; Cabezas, Angel; Gutierrez-Zotes, Alfonso; Sole, Montse; Algora, Maria Jose; Ortega, Laura; Martorell, Lourdes; Sanchez-Gistau, Vanessa; Vilella, Elisabet; Labad, Javier;

Departamento: Infermeria

Autor/es de la URV: Martorell Bonet, Lourdes / Ortega Sanz, Laura

Palabras clave: Type-2 diabetes-mellitus Serum interleukin-6 Risk Insulin Impairment Glycated haemoglobin Glucose-tolerance Glucose Free-thyroxine levels Early psychosis Drug-naive patients Cortisol awakening response Cortisol Cognition 1st-episode schizophrenia glucose early psychosis cortisol cognition

Resumen: Background Glucose abnormalities and cognitive alterations are present before the onset of schizophrenia. We aimed to study whether glucose metabolism parameters are associated with cognitive functioning in recent-onset psychosis (ROP) patients while adjusting for hypothalamic-pituitary adrenal (HPA) axis measures. Methods Sixty ROP outpatients and 50 healthy subjects (HS) were studied. Cognitive function was assessed with the MATRICS Consensus Cognitive Battery. Glycated haemoglobin (HbA1(c)), glucose, insulin, and C-peptide levels were determined in plasma. The HOMA-insulin resistance index was calculated. Salivary samples were obtained at home on another day to assess the cortisol awakening response and cortisol levels during the day. Univariate analyses were conducted to explore the association between glucose metabolism parameters and cognitive tasks. For those parameters that were more clearly associated with the cognitive outcome, multiple linear regression analyses were conducted to adjust for covariates. Each cognitive task was considered the dependent variable. Covariates were age, sex, education level, diagnosis, antipsychotic and benzodiazepine treatment, body mass index (BMI), smoking, and HPA axis measures. Potential interactions between diagnosis and glucose parameters were tested. Results There were no significant differences in HPA axis measures or glucose parameters, with the exception of C-peptide (that was higher in ROP patients), between groups. ROP patients had a lower performance than HS in all cognitive tasks (p < 0.01 for all tasks). Of all glucose metabolism parameters, HbA1c levels were more clearly associated with cognitive impairment in cognitive tasks dealing with executive functions and visual memory in both ROP patients and HS. Multivariate analyses found a significant negative association between HbA1c and cognitive functioning in five cognitive tasks dealing with executive functions, visual memory and attention/vigilance (a ROP diagnosis by HbA1(c) negative interaction was found in this latter cognitive domain, suggesting that HBA1(c) levels are associated with impaired attention only in ROP patients). Conclusions Our study found that HbA1(c) was negatively associated with cognitive functioning in both ROP patients and HS in tasks dealing with executive functions and visual memory. In ROP patients, HbA1(c) was also associated with impaired attention. These results were independent of BMI and measures of HPA axis activity.

Áreas temáticas: Psychiatry and mental health Psychiatry Psicología Medicina ii Medicina i Interdisciplinar Ensino Engenharias iv Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Astronomia / física Administração pública e de empresas, ciências contábeis e turismo

ISSN: 16640640

Direcció de correo del autor: lourdes.martorell@urv.cat laura.ortega@urv.cat

Identificador del autor: 0000-0003-4999-2197 0000-0003-2476-7700

Fecha de alta del registro: 2023-05-14

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.frontiersin.org/articles/10.3389/fpsyt.2020.00455/full

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Frontiers In Psychiatry. 11 (455): 455-

Referencia de l'ítem segons les normes APA: Montalvo, Itziar; Gonzalez-Rodriguez, Alexandre; Cabezas, Angel; Gutierrez-Zotes, Alfonso; Sole, Montse; Algora, Maria Jose; Ortega, Laura; Martorell, (2020). Glycated Haemoglobin Is Associated With Poorer Cognitive Performance in Patients With Recent-Onset Psychosis. Frontiers In Psychiatry, 11(455), 455-. DOI: 10.3389/fpsyt.2020.00455

DOI del artículo: 10.3389/fpsyt.2020.00455

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications