Autor según el artículo: Taltavull N; Miralles-Pérez B; Nogués MR; Ramos-Romero S; Méndez L; Medina I; Torres JL; Romeu M

Departamento: Ciències Mèdiques Bàsiques

Autor/es de la URV: Miralles Pérez, Bernat / Nogués Llort, Maria Rosa / Romeu Ferran, Marta / Taltavull Anglada, Núria

Palabras clave: Steatosis Sphingomyelin synthase 2 Proanthocyanidins Polyunsaturated fatty-acids Polyphenols Oxidative stress Omega-3 pufa Omega-3 Metabolism Liver Glucose Diacylglycerol Ceramide Biological samples Antioxidants polyphenols omega-3 diacylglycerol ceramide antioxidants

Resumen: Diacylglycerols (DAG) and ceramides have been suggested as early predictors of insulin resistance. This study was aimed to examine the combined effects of fish oil (FO) and grape seed extract (GSE) on hepatic endogenous antioxidants, DAG and ceramides in diet-induced early stages of insulin resistance. Thirty-five rats were fed one of the following diets: (1) a standard diet (STD group), (2) a high-fat high-sucrose diet (HFHS group), (3) an HFHS diet enriched with FO (FO group), (4) an HFHS diet enriched with GSE (GSE group) or (5) an HFHS diet enriched with FO and GSE (FO + GSE group). In the liver, endogenous antioxidants were measured using spectrophotometric and fluorometric techniques, and non-targeted lipidomics was conducted for the assessment of DAG and ceramides. After 24 weeks, the FO + GSE group showed increased glutathione peroxidase activity, as well as monounsaturated fatty acid and polyunsaturated fatty acid-containing DAG, and long-chain fatty acid-containing ceramides abundances compared to the STD group. The FO and GSE combination induced similar activation of the antioxidant system and bioactive lipid accumulation in the liver than the HFHS diet without supplementation. In addition, the FO and GSE combination increased the abundances of polyunsaturated fatty acid-containing DAG in the liver.

Áreas temáticas: Zootecnia / recursos pesqueiros Química Pharmacology, toxicology and pharmaceutics (miscellaneous) Pharmacology & pharmacy Pharmaceutical science Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Geociências Farmacia Engenharias iii Engenharias ii Educação física Drug discovery Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Biotecnología Biodiversidade Astronomia / física

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 16603397

Direcció de correo del autor: bernat.miralles@urv.cat nuria.taltavull@urv.cat mariarosa.nogues@urv.cat marta.romeu@urv.cat bernat.miralles@urv.cat

Identificador del autor: 0000-0003-1294-7069 0000-0002-3340-2650 0000-0003-4626-5672 0000-0002-2131-1858 0000-0003-1294-7069

Fecha de alta del registro: 2023-02-19

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://www.mdpi.com/1660-3397/18/6/318

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: Marine Drugs. 18 (6):

Referencia de l'ítem segons les normes APA: Taltavull N; Miralles-Pérez B; Nogués MR; Ramos-Romero S; Méndez L; Medina I; Torres JL; Romeu M (2020). Effects of Fish Oil and Grape Seed Extract Combination on Hepatic Endogenous Antioxidants and Bioactive Lipids in Diet-Induced Early Stages of Insulin Resistance in Rats. Marine Drugs, 18(6), -. DOI: 10.3390/md18060318

DOI del artículo: 10.3390/md18060318

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2020

Tipo de publicación: Journal Publications