Autor según el artículo: Valls, Rosa M.; Pedret, Anna; Calderon-Perez, Lorena; Llaurado, Elisabet; Pla-Paga, Laura; Companys, Judit; Moragas, Ana; Martin-Lujan, Francisco; Ortega, Yolanda; Giralt, Montse; Romeu, Marta; Rubio, Laura; Mayneris-Perxachs, Jordi; Canela, Nuria; Puiggros, Francesc; Caimari, Antoni; Del Bas, Josep M.; Arola, Lluis; Sola, Rosa;

Departamento: Medicina i Cirurgia Bioquímica i Biotecnologia

Autor/es de la URV: Arola Ferrer, Luis Maria / Calderon Pérez, Lorena / Companys Alemany, Judit / Giralt Batista, Montserrat / Llauradó Ribé, Elisabet / Martín Lujan, Francisco Manuel / Pedret Figuerola, Anna / PLA PAGA, LAURA / Romeu Ferran, Marta / Solà Alberich, Rosa Maria / Valls Zamora, Rosa Maria

Palabras clave: Visfatin Stroke Risk Pulse pressure Pre-hypertension Orange juice Metaanalysis Hesperidin Glucosyl hesperidin Flavonoid intake Flavanones Double-blind Cardiovascular-disease Blood pressure Arterial stiffness pre-hypertension orange juice hesperidin blood pressure

Resumen: Purpose To assess the sustained and acute effects, as well as the influence of sustained consumption on the acute effects, of orange juice (OJ) with a natural hesperidin content and hesperidin-enriched OJ (EOJ) on blood (BP) and pulse (PP) pressures in pre- and stage-1 hypertensive individuals. Methods In a randomized, parallel, double-blind, placebo-controlled trial, participants (n = 159) received 500 mL/day of control drink, OJ, or EOJ for 12 weeks. Two dose-response studies were performed at baseline and after 12 weeks. Results A single EOJ dose (500 mL) reduced systolic BP (SBP) and PP, with greater changes after sustained treatment where a decrease in diastolic BP (DBP) also occurred (P < 0.05). SBP and PP decreased in a dose-dependent manner relative to the hesperidin content of the beverages throughout the 12 weeks (P < 0.05). OJ and EOJ decreased homocysteine levels at 12 weeks versus the control drink (P < 0.05). After 12 weeks of EOJ consumption, four genes related to hypertension (PTX3, NLRP3, NPSR1 and NAMPT) were differentially expressed in peripheral blood mononuclear cells (P < 0.05). Conclusion Hesperidin in OJ reduces SBP and PP after sustained consumption, and after a single dose, the chronic consumption of EOJ enhances its postprandial effect. Decreases in systemic and transcriptomic biomarkers were concomitant with BP and PP changes. EOJ could be a useful co-adjuvant tool for BP and PP management in pre- and stage-1 hypertensive individuals.

Áreas temáticas: Serviço social Saúde coletiva Química Nutrition and dietetics Nutrition & dietetics Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Farmacia Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos

Acceso a la licencia de uso: https://creativecommons.org/licenses/by/3.0/es/

ISSN: 14366207

Direcció de correo del autor: judit.companys@urv.cat paco.martin@urv.cat lorena.calderon@urv.cat elisabet.llaurado@urv.cat anna.pedret@urv.cat lluis.arola@urv.cat rosa.sola@urv.cat marta.romeu@urv.cat rosamaria.valls@urv.cat lorena.calderon@urv.cat judit.companys@urv.cat judit.companys@urv.cat montse.giralt@urv.cat

Identificador del autor: 0000-0003-1485-0818 0000-0003-0359-3588 0000-0003-0766-0733 0000-0002-7439-9531 0000-0002-5327-932X 0000-0003-2767-1974 0000-0002-8359-235X 0000-0002-2131-1858 0000-0002-3351-0942 0000-0003-0766-0733 0000-0003-1485-0818 0000-0003-1485-0818 0000-0002-7073-577X

Fecha de alta del registro: 2023-02-27

Versión del articulo depositado: info:eu-repo/semantics/publishedVersion

Enlace a la fuente original: https://link.springer.com/article/10.1007/s00394-020-02279-0

URL Documento de licencia: http://repositori.urv.cat/ca/proteccio-de-dades/

Referencia al articulo segun fuente origial: European Journal Of Nutrition. 60 (3): 1277-1288

Referencia de l'ítem segons les normes APA: Valls, Rosa M.; Pedret, Anna; Calderon-Perez, Lorena; Llaurado, Elisabet; Pla-Paga, Laura; Companys, Judit; Moragas, Ana; Martin-Lujan, Francisco; Ort (2021). Effects of hesperidin in orange juice on blood and pulse pressures in mildly hypertensive individuals: a randomized controlled trial (Citrus study). European Journal Of Nutrition, 60(3), 1277-1288. DOI: 10.1007/s00394-020-02279-0

DOI del artículo: 10.1007/s00394-020-02279-0

Entidad: Universitat Rovira i Virgili

Año de publicación de la revista: 2021

Tipo de publicación: Journal Publications